(Q37423906)

20 August 2017

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title

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide (English)

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20 August 2017

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Peter Faller

1

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PubMed ID

19322475

20 August 2017

Christelle Hureau

series ordinal

2

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PubMed ID

19322475

20 August 2017

language of work or name

English

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publication date

26 November 2008

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20 August 2017

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20 August 2017

7

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20 August 2017

1080-1094

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Alzheimer's disease is a synaptic failure

20 August 2017

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Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

21 January 2018

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Pathways towards and away from Alzheimer's disease

21 January 2018

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease

21 January 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

21 January 2018

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NMR studies in aqueous solution fail to identify significant conformational differences between the monomeric forms of two Alzheimer peptides with widely different plaque-competence, A beta(1-40)(ox) and A beta(1-42)(ox).

21 January 2018

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Structure and function of amyloid in Alzheimer's disease

21 January 2018

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Solution structures of micelle-bound amyloid beta-(1-40) and beta-(1-42) peptides of Alzheimer's disease

21 January 2018

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Structural analysis of Alzheimer's beta(1-40) amyloid: protofilament assembly of tubular fibrils.

21 January 2018

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In situ characterization of beta-amyloid in Alzheimer's diseased tissue by synchrotron Fourier transform infrared microspectroscopy

21 January 2018

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Molecular structure of amyloid fibrils: insights from solid-state NMR.

21 January 2018

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Protein folding and misfolding

21 January 2018

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Protein misfolding, functional amyloid, and human disease

21 January 2018

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Redox metals and neurodegenerative disease

21 January 2018

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The metallobiology of Alzheimer's disease

21 January 2018

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The redox chemistry of the Alzheimer's disease amyloid beta peptide.

21 January 2018

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Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

21 January 2018

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Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

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Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease

21 January 2018

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Rapid induction of Alzheimer A beta amyloid formation by zinc.

21 January 2018

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

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Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.

21 January 2018

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

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Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

21 January 2018

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

21 January 2018

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Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

21 January 2018

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The amyloid beta peptide (Abeta(1-40)) is thermodynamically soluble at physiological concentrations

21 January 2018

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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

21 January 2018

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

21 January 2018

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Products of Cu(II)-catalyzed oxidation in the presence of hydrogen peroxide of the 1-10, 1-16 fragments of human and mouse beta-amyloid peptide

21 January 2018

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Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical

21 January 2018

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Redox-active metals, oxidative stress, and Alzheimer's disease pathology

21 January 2018

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Cu(2+) Inhibits the Aggregation of Amyloid beta-Peptide(1-42) in vitro We thank JEOL for the AFM measurement. This work was supported in part by Grants-in-Aid from the Japanese Ministry of Education, Science, Sports, and Culture, and a Grant from "R

21 January 2018

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Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide

21 January 2018

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Metal complexing agents as therapies for Alzheimer's disease

21 January 2018

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New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity

21 January 2018

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Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

21 January 2018

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Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

21 January 2018

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In vivo reduction of amyloid-beta by a mutant copper transporter

21 January 2018

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Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

21 January 2018

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Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

21 January 2018

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Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases.

21 January 2018

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Copper and Alzheimer's disease.

21 January 2018

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Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis).

21 January 2018

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Coordination abilities of the 1-16 and 1-28 fragments of beta-amyloid peptide towards copper(II) ions: a combined potentiometric and spectroscopic study

21 January 2018

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N-Terminal deletions modify the Cu2+ binding site in amyloid-beta

21 January 2018

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Identifying the minimal copper- and zinc-binding site sequence in amyloid-beta peptides

21 January 2018

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Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques

21 January 2018

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Structural and thermodynamical properties of CuII amyloid-beta16/28 complexes associated with Alzheimer's disease.

21 January 2018

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Cu(II) binding to monomeric, oligomeric, and fibrillar forms of the Alzheimer's disease amyloid-beta peptide.

21 January 2018

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Redox reactions of copper complexes formed with different beta-amyloid peptides and their neuropathological [correction of neuropathalogical] relevance

21 January 2018

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Binding of Zn(II), Cu(II), and Fe(II) ions to Alzheimer's A beta peptide studied by fluorescence

21 January 2018

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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

21 January 2018

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Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

21 January 2018

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Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

21 January 2018

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Changes in apparent pH on freezing aqueous buffer solutions and their relevance to biochemical electron-paramagnetic-resonance spectroscopy

21 January 2018

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Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes.

21 January 2018

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Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid

21 January 2018

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Role of aspartate-1 in Cu(II) binding to the amyloid-beta peptide of Alzheimer's disease

21 January 2018

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The aggregated state of amyloid-beta peptide in vitro depends on Cu2+ ion concentration.

21 January 2018

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Structural implications derived from the analysis of electron paramagnetic resonance spectra of natural and artificial copper proteins.

21 January 2018

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Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

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Metal binding in amyloid beta-peptides shows intra- and inter-peptide coordination modes

21 January 2018

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NMR reveals anomalous copper(II) binding to the amyloid Abeta peptide of Alzheimer's disease.

21 January 2018

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Direct evidence that all three histidine residues coordinate to Cu(II) in amyloid-beta1-16.

21 January 2018

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Structural features of the Cu(II) complex with the rat Abeta(1-28) fragment.

21 January 2018

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Studies on human lactoferrin by electron paramagnetic resonance, fluorescence, and resonance Raman spectroscopy

21 January 2018

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VMD: visual molecular dynamics

21 January 2018

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Cu(II) interaction with N-terminal fragments of human and mouse beta-amyloid peptide

21 January 2018

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

21 January 2018

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Ab initio modelling of the structure and redox behaviour of copper(I) bound to a His-His model peptide: relevance to the beta-amyloid peptide of Alzheimer's disease.

21 January 2018

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Oxidative switches in functioning of mammalian copper chaperone Cox17

21 January 2018

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Ascorbate regulation and its neuroprotective role in the brain

21 January 2018

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Characterization of the ZnII binding to the peptide amyloid-beta1-16 linked to Alzheimer's disease.

21 January 2018

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Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging

21 January 2018

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Zinc binding to amyloid-beta: isothermal titration calorimetry and Zn competition experiments with Zn sensors.

21 January 2018

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High-resolution NMR studies of the zinc-binding site of the Alzheimer's amyloid beta-peptide.

21 January 2018

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NMR studies of the Zn2+ interactions with rat and human beta-amyloid (1-28) peptides in water-micelle environment.

21 January 2018

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Quantification of the binding constant of copper(II) to the amyloid-beta peptide

21 January 2018

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Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-beta peptide

21 January 2018

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Cu(II) complexation by "non-coordinating" N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES buffer).

21 January 2018

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Determining thermodynamic parameters from isothermal calorimetric isotherms of the binding of macromolecules to metal cations originally chelated by a weak ligand

21 January 2018

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Aluminum-triggered structural modifications and aggregation of beta-amyloids

21 January 2018

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A method based on ICP-MS for the analysis of Alzheimer's amyloid plaques.

21 January 2018

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Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors

21 January 2018

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Effect of the two conserved prolines of human growth inhibitory factor (metallothionein-3) on its biological activity and structure fluctuation: comparison with a mutant protein.

21 January 2018

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C-terminal domain of the membrane copper transporter Ctr1 from Saccharomyces cerevisiae binds four Cu(I) ions as a cuprous-thiolate polynuclear cluster: sub-femtomolar Cu(I) affinity of three proteins involved in copper trafficking.

21 January 2018

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Concentrations of extracellular free zinc (pZn)e in the central nervous system during simple anesthetization, ischemia and reperfusion

21 January 2018

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Release of endogenous Zn2+ from brain tissue during activity.

21 January 2018

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Stimulation-induced uptake and release of zinc in hippocampal slices

21 January 2018

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Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress.

21 January 2018

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Evidence for release of copper in the brain: depolarization-induced release of newly taken-up 67copper

21 January 2018

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Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability

21 January 2018

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NMDA receptor activation mediates copper homeostasis in hippocampal neurons

21 January 2018

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Imaging of copper, zinc, and other elements in thin section of human brain samples (hippocampus) by laser ablation inductively coupled plasma mass spectrometry

21 January 2018

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Zinc-amyloid beta interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species.

21 January 2018

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Dual nanomolar and picomolar Zn(II) binding properties of metallothionein

21 January 2018

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Insights into the amyloid folding problem from solid-state NMR

21 January 2018

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Zinc Binding to Alzheimer's Aβ(1–16) Peptide Results in Stable Soluble Complex

21 January 2018

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Zinc binding properties of the amyloid fragment Aβ(1–16) studied by electrospray-ionization mass spectrometry

21 January 2018

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Investigations of the molecular mechanism of metal-induced Abeta (1-40) amyloidogenesis

21 January 2018

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B813398K

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20 August 2017

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PubMed ID

19322475