(Q35019437)

5 August 2017

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title

Metal complexing agents as therapies for Alzheimer's disease (English)

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5 August 2017

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Ashley I Bush

1

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publication date

1 November 2002

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5 August 2017

published in

Neurobiology of Aging

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5 August 2017

volume

23

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5 August 2017

issue

6

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5 August 2017

page(s)

1031-1038

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Release of endogenous Zn2+ from brain tissue during activity.

5 August 2017

cites work

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7 January 2021

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

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7 January 2021

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

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7 January 2021

Rapid induction of Alzheimer A beta amyloid formation by zinc.

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7 January 2021

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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7 January 2021

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

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7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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7 January 2021

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene

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7 January 2021

Intramuscular desferrioxamine in patients with Alzheimer's disease

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7 January 2021

Metal chelation as a potential therapy for Alzheimer's disease.

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7 January 2021

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

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7 January 2021

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

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7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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7 January 2021

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

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7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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7 January 2021

Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia.

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Evidence for release of copper in the brain: depolarization-induced release of newly taken-up 67copper

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7 January 2021

The beta A4 amyloid precursor protein binding to copper.

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7 January 2021

Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease.

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7 January 2021

Stimulation-induced uptake and release of zinc in hippocampal slices

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7 January 2021

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7 January 2021

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Differential degeneration of the cerebral microvasculature in Alzheimer's disease.

1 reference

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7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta-peptide 1-42-associated oxidative stress and neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

The effects of disulfiram on equine hepatic alcohol dehydrogenase and its efficiency against alcoholism: vinegar effect

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

The neurotoxicity of zinc in the rat hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type

1 reference

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7 January 2021

Copper, iron and zinc in Alzheimer's disease senile plaques.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

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7 January 2021

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Oxidative damage is the earliest event in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

65zinc uptake from blood into brain and other tissues in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

65Zn uptake from blood into brain in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Effects of 2,2'-dipyridyl and related compounds on platelet prostaglandin synthesis and platelet function

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Redox-active iron mediates amyloid-beta toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Oxidative damage in Alzheimer's.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

The structure of neuritic plaque in the cerebral cortex of aged rats

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Characterization of beta-amyloid peptide from human cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Beta-amyloid protein promotes neuritic branching in hippocampal cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Amyloid beta protein enhances the survival of hippocampal neurons in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

The binding of receptor-recognized alpha2-macroglobulin to the low density lipoprotein receptor-related protein and the alpha2M signaling receptor is decoupled by oxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900120-3

7 January 2021

Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.

1 reference

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7 January 2021

10.1016/S0197-4580(02)00120-3

Identifiers

DOI

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5 August 2017

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