(Q38057607)

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17 February 2020

title

Drug repositioning for Alzheimer's disease (English)

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17 February 2020

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3

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17 February 2020

Anne Corbett

1

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17 February 2020

Stephen Dunnett

5

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17 February 2020

Patrick G. Kehoe

12

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17 February 2020

Clive Ballard

17

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17 February 2020

10

Cornelius Katona

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17 February 2020

author name string

James Pickett

2

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17 February 2020

Jonathan Corcoran

4

1 reference

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17 February 2020

Paul Edison

6

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17 February 2020

Jim J Hagan

7

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17 February 2020

Clive Holmes

8

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17 February 2020

Emma Jones

9

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17 February 2020

Ian Kearns

11

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17 February 2020

Amrit Mudher

13

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17 February 2020

Anthony Passmore

14

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17 February 2020

Nicola Shepherd

15

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17 February 2020

Frank Walsh

16

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17 February 2020

publication date

1 November 2012

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Nature Reviews Drug Discovery

17 February 2020

published in

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17 February 2020

volume

11

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17 February 2020

page(s)

833-846

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17 February 2020

issue

11

1 reference

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https://scigraph.springernature.com/pub.10.1038/nrd3869

17 February 2020

exact match

0 references

cites work

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

31 March 2020

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31 March 2020

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Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer's disease.

31 March 2020

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Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

31 March 2020

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Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

31 March 2020

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Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death

31 March 2020

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Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.

31 March 2020

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

31 March 2020

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Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

31 March 2020

1 reference

Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice

31 March 2020

1 reference

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

31 March 2020

1 reference

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria

31 March 2020

1 reference

Alzheimer's disease: clinical trials and drug development

31 March 2020

1 reference

Discovery and preclinical validation of drug indications using compendia of public gene expression data

31 March 2020

1 reference

Drug repositioning: identifying and developing new uses for existing drugs

31 March 2020

1 reference

Amantadine: the journey from fighting flu to treating Parkinson disease.

31 March 2020

1 reference

Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study

31 March 2020

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15-year longitudinal study of blood pressure and dementia

31 March 2020

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Midlife blood pressure and dementia: the Honolulu-Asia aging study.

31 March 2020

1 reference

The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function.

31 March 2020

1 reference

The age-dependent relation of blood pressure to cognitive function and dementia

31 March 2020

1 reference

Role of vascular risk factors and vascular dysfunction in Alzheimer's disease

31 March 2020

1 reference

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

31 March 2020

1 reference

Angiotensins in Alzheimer's disease - friend or foe?

31 March 2020

1 reference

The renin-angiotensin system and antihypertensive drugs in Alzheimer's disease: current standing of the angiotensin hypothesis?

31 March 2020

1 reference

Brain renin-angiotensin--a new look at an old system

31 March 2020

1 reference

The renin-angiotensin system in the brain: possible therapeutic implications for AT(1)-receptor blockers

31 March 2020

1 reference

Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease

31 March 2020

1 reference

Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease

31 March 2020

1 reference

Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling

31 March 2020

1 reference

Telmisartan prevented cognitive decline partly due to PPAR-gamma activation

31 March 2020

1 reference

Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease

31 March 2020

1 reference

Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis

31 March 2020

1 reference

Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias

31 March 2020

1 reference

Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies

31 March 2020

1 reference

The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial

31 March 2020

1 reference

Effect of baseline cognitive function and antihypertensive treatment on cognitive and cardiovascular outcomes: Study on COgnition and Prognosis in the Elderly (SCOPE).

31 March 2020

1 reference

Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment.

31 March 2020

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Effects of nimodipine on cerebral blood flow and neuropsychological outcome after cardiac surgery.

31 March 2020

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Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization

31 March 2020

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Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier.

31 March 2020

1 reference

L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease

31 March 2020

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Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells.

31 March 2020

1 reference

Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier

31 March 2020

1 reference

Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with beta-amyloid in rats.

31 March 2020

1 reference

A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.

31 March 2020

1 reference

Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study.

31 March 2020

1 reference

Antihypertensive medication use and incident Alzheimer disease: the Cache County Study.

31 March 2020

1 reference

The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study

31 March 2020

1 reference

Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study

31 March 2020

1 reference

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

31 March 2020

1 reference

Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans

31 March 2020

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Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies.

31 March 2020

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Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

31 March 2020

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Common pathological processes in Alzheimer disease and type 2 diabetes: a review

31 March 2020

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Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model

31 March 2020

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Insulin-like growth factor-I, cognition and brain aging

31 March 2020

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Alzheimer-like changes in rat models of spontaneous diabetes.

31 March 2020

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The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease

31 March 2020

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Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease

31 March 2020

1 reference

Insulin and the insulin receptor in experimental models of learning and memory.

31 March 2020

1 reference

Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults.

31 March 2020

1 reference

A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation

31 March 2020

1 reference

Intranasal insulin improves cognition and modulates beta-amyloid in early AD.

31 March 2020

1 reference

Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial

31 March 2020

1 reference

The role of GLP-1 in neuronal activity and neurodegeneration

31 March 2020

1 reference

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.

31 March 2020

1 reference

(Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains

31 March 2020

1 reference

A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells

31 March 2020

1 reference

Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats.

31 March 2020

1 reference

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

31 March 2020

1 reference

Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

31 March 2020

1 reference

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

31 March 2020

1 reference

Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

31 March 2020

1 reference

Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier.

31 March 2020

1 reference

Entry of exendin-4 into brain is rapid but may be limited at high doses

31 March 2020

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Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study

31 March 2020

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Anti-amyloidogenic activity of tetracyclines: studies in vitro.

31 March 2020

1 reference

Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus

31 March 2020

1 reference

Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid.

31 March 2020

1 reference

Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice

31 March 2020

1 reference

Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding

31 March 2020

1 reference

Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation

31 March 2020

1 reference

Increases in β-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-κB pathway activation.

31 March 2020

1 reference

Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology

31 March 2020

1 reference

Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice

31 March 2020

1 reference

Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease.

31 March 2020

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Dose translation from animal to human studies revisited

31 March 2020

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Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial.

31 March 2020

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Minocycline for Huntington's disease: an open label study

31 March 2020

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Neuroprotection in Huntington's disease: a 2-year study on minocycline

31 March 2020

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Minocycline in Huntington's disease: a pilot study

31 March 2020

1 reference

A futility study of minocycline in Huntington's disease

31 March 2020

1 reference

A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month results

31 March 2020

1 reference

Evidence for defective retinoid transport and function in late onset Alzheimer's disease

31 March 2020

1 reference

Disruption of the retinoid signalling pathway causes a deposition of amyloid beta in the adult rat brain

31 March 2020

1 reference

Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in beta-amyloid deposits in the cerebral cortex of vitamin A deprived rats

31 March 2020

1 reference

Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model.

31 March 2020

1 reference

Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin

31 March 2020

1 reference

Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β.

31 March 2020

1 reference

Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice.

31 March 2020

1 reference

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

31 March 2020

1 reference

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

31 March 2020

1 reference

Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth.

31 March 2020

1 reference

Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways

31 March 2020

1 reference

All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

31 March 2020

1 reference

Towards retinoid therapy for Alzheimer's disease

31 March 2020

1 reference

Persistence of cognitive impairment in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with nortriptyline and paroxetine

31 March 2020

1 reference

An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers

31 March 2020

1 reference

Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials

31 March 2020

1 reference

Systemic inflammation and disease progression in Alzheimer disease

31 March 2020

1 reference

Improvement of cognition, a potential benefit of anti-TNF therapy in elderly patients with rheumatoid arthritis

31 March 2020

1 reference

Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial

31 March 2020

1 reference

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

31 March 2020

1 reference

A feasibility and tolerability study of lithium in Alzheimer's disease.

31 March 2020

1 reference

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

31 March 2020

1 reference

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes

31 March 2020

1 reference

Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin

31 March 2020

1 reference

A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer's disease

31 March 2020

1 reference

Chronic divalproex sodium use and brain atrophy in Alzheimer disease

31 March 2020

1 reference

Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study

31 March 2020

1 reference

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease.

31 March 2020

1 reference

Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia

31 March 2020

1 reference

12 December 2020

Nitrendipine and mefruside in elderly hypertensives: effects on blood pressure, cardiac output, cerebral blood flow and metabolic parameters

1 reference

12 December 2020

Cannabinoids for the treatment of dementia

1 reference

12 December 2020

Nimodipine for primary degenerative, mixed and vascular dementia

1 reference

12 December 2020

Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines

1 reference

12 December 2020

Apolipoprotein E genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer's patients--an open-label trial.

1 reference

12 December 2020

Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes.

1 reference

12 December 2020

Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease

1 reference

12 December 2020

Kinetics of tissue distribution and elimination of retinoid drugs in the rat. I. Acitretin.

1 reference

12 December 2020

Angiotensin II-inhibiting drugs have no effect on intraneuronal Aβ or oligomeric Aβ levels in a triple transgenic mouse model of Alzheimer's disease.

1 reference

12 December 2020

Blocking the Ca(2+)-activated cytotoxic mechanisms of cholinergic neuronal death: a novel treatment strategy for Alzheimer's disease

1 reference

12 December 2020

Herpes simplex virus type 1 in Alzheimer's disease: the enemy within

1 reference

12 December 2020

Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3869

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23123941%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference