(Q33898352)

29 July 2017

title

Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity (English)

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29 July 2017

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Michael Blaber

5

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Michael Fehlings

object named as

Michael G Fehlings

6

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author name string

Hyesook Yoon

1

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29 July 2017

Maja Radulovic

2

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29 July 2017

Jianmin Wu

3

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29 July 2017

Sachiko I Blaber

4

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29 July 2017

Isobel A Scarisbrick

7

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29 July 2017

language of work or name

English

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publication date

27 May 2013

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Journal of Neurochemistry

29 July 2017

published in

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29 July 2017

volume

127

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29 July 2017

issue

2

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29 July 2017

page(s)

283-298

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A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity

29 July 2017

cites work

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Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis

5 July 2018

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Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling

5 July 2018

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Thrombin activity associated with neuronal damage during acute focal ischemia

5 July 2018

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Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.

5 July 2018

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Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis

5 July 2018

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5 July 2018

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Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus

5 July 2018

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Regulation of choline acetyltransferase expression by 17 β-oestradiol in NSC-34 cells and in the spinal cord

5 July 2018

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Targeting protease-activated receptor-1 with cell-penetrating pepducins in lung cancer

5 July 2018

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Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins

5 July 2018

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Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival.

5 July 2018

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Thrombin induces rapid disassembly of claudin-5 from the tight junction of endothelial cells

5 July 2018

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Proteinase-activated receptors in the nucleus of the solitary tract: evidence for glial-neural interactions in autonomic control of the stomach

5 July 2018

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Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function

5 July 2018

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Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Dynamic role of kallikrein 6 in traumatic spinal cord injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Cell culture models to investigate the selective vulnerability of motoneuronal mitochondria to familial ALS-linked G93ASOD1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Upregulation of protease-activated receptor-1 in astrocytes in Parkinson disease: astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

The deleterious or beneficial effects of different agents in intracerebral hemorrhage: think big, think small, or is hematoma size important?

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Signaling from cAMP/PKA to MAPK and synaptic plasticity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Activated microglia (BV-2) facilitation of TNF-alpha-mediated motor neuron death in vitro.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Activity of a newly identified serine protease in CNS demyelination

5 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

5 July 2018

Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 2. Quantitative neuroanatomical assessment and analysis of the relationships between axonal tracts, residual tissue, and locomotor re

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 1. Clip design, behavioral outcomes, and histopathology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Enzymatic properties of rat myelencephalon-specific protease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

MSP, a trypsin-like serine protease, is abundantly expressed in the human nervous system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Thrombin attenuation is neuroprotective in the injured rat optic nerve

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Serine proteases and brain damage - is there a link?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Development and characterisation of a glutamate-sensitive motor neurone cell line

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Prothrombin mRNA is expressed by cells of the nervous system.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Domains specifying thrombin–receptor interaction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brain

5 July 2018

1 reference

21 January 2018

1 reference

Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains.

21 January 2018

1 reference

Bone morphogenetic protein 2 inhibits neurite outgrowth of motor neuron-like NSC-34 cells and up-regulates its type II receptor

21 January 2018

1 reference

Stress-induced spine loss in the medial amygdala is mediated by tissue-plasminogen activator.

21 January 2018

1 reference

Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis

21 January 2018

1 reference

Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: role of microglial NADPH oxidase.

21 January 2018

1 reference

Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease

21 January 2018

1 reference

Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures

21 January 2018

1 reference

Modulation of hippocampal neuron survival by thrombin and factor Xa.

21 January 2018

1 reference

Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons

21 January 2018

1 reference

Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro.

21 January 2018

1 reference

Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.

21 January 2018

1 reference

Thrombin may contribute to the pathophysiology of central nervous system injury

21 January 2018

1 reference

Trimethyltin-induced differential expression of PAR subtypes in reactive astrocytes of the rat hippocampus

21 January 2018

1 reference

Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors.

21 January 2018

1 reference

Glutamate release in severe brain ischaemia is mainly by reversed uptake.

21 January 2018

1 reference

Potential scope of action of tissue kallikreins in CNS immune-mediated disease

21 January 2018

1 reference

Distribution of 15 human kallikreins in tissues and biological fluids

21 January 2018

1 reference

Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia.

21 January 2018

1 reference

Participation of protease-activated receptor-1 in thrombin-induced microglial activation

21 January 2018

1 reference

Extracellular neurosin degrades α-synuclein in cultured cells.

21 January 2018

1 reference

Differential expression of neuropsin and protease M/neurosin in oligodendrocytes after injury to the spinal cord

21 January 2018

1 reference

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

21 January 2018

1 reference

Expression of myelencephalon-specific protease in transient middle cerebral artery occlusion model of rat brain.

21 January 2018

1 reference

Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

An Adverse Role for Matrix Metalloproteinase 12 after Spinal Cord Injury in Mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Bipotent cortical progenitor cells process conflicting cues for neurons and glia in a hierarchical manner.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Nervous system-specific expression of a novel serine protease: regulation in the adult rat spinal cord by excitotoxic injury.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097186

Human kallikrein 6 (zyme/protease M/neurosin): a new serum biomarker of ovarian carcinoma

29 October 2018

1 reference

Preferential expression of myelencephalon-specific protease by oligodendrocytes of the adult rat spinal cord white matter

21 January 2018

1 reference

12 December 2020

Potentiation of NMDA receptor function by the serine protease thrombin

1 reference

12 December 2020

Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease

1 reference

12 December 2020

Upregulation of neurotoxic serine proteases, prothrombin, and protease-activated receptor 1 early after spinal cord injury

1 reference

12 December 2020

Glutamate neurotoxicity in spinal cord cell culture

1 reference

12 December 2020

Protease nexin-1 and thrombin: injury-related processes in the brain

1 reference

12 December 2020

Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment

1 reference

12 December 2020

An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus

1 reference

12 December 2020

Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation

1 reference

12 December 2020

Proteinase-Activated Receptor-2 Induction by Neuroinflammation Prevents Neuronal Death during HIV Infection

1 reference

12 December 2020

Focal ischemia induces expression of protease-activated receptor1 (PAR1) and PAR3 on microglia and enhances PAR4 labeling in the penumbra

1 reference

12 December 2020

Identifiers

DOI

10.1111/JNC.12293

1 reference

29 July 2017

1 reference

29 July 2017

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