(Q33910576)

30 July 2017

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title

Ubiquitin-mediated proteolysis: biological regulation via destruction (English)

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30 July 2017

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1

Ciechanover A

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30 July 2017

Orian A

2

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30 July 2017

Schwartz AL

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

1 May 2000

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30 July 2017

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30 July 2017

volume

22

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30 July 2017

issue

5

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30 July 2017

page(s)

442-451

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Mechanisms of Intracellular Protein Breakdown

30 July 2017

cites work

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Modes of regulation of ubiquitin-mediated protein degradation

21 January 2018

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Substrate targeting in the ubiquitin system

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21 January 2018

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The anaphase-promoting complex: new subunits and regulators

21 January 2018

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SCF and Cullin/Ring H2-based ubiquitin ligases

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A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.

21 January 2018

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

21 January 2018

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A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

21 January 2018

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Retrograde protein translocation: ERADication of secretory proteins in health and disease

21 January 2018

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21 January 2018

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A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

21 January 2018

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Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

21 January 2018

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

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Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination

21 January 2018

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Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

21 January 2018

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Ubiquitination mediated by the Npi1p/Rsp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease

21 January 2018

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

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A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

21 January 2018

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The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

21 January 2018

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Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

21 January 2018

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CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

21 January 2018

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Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family

21 January 2018

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The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

21 January 2018

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Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

21 January 2018

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Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20.

21 January 2018

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 January 2018

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Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

21 January 2018

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SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex

21 January 2018

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Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

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An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

21 January 2018

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A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

21 January 2018

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Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

21 January 2018

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

21 January 2018

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The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

21 January 2018

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

21 January 2018

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Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain

21 January 2018

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The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain

21 January 2018

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

21 January 2018

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21 January 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

21 January 2018

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The multiubiquitin-chain-binding protein Mcb1 is a component of the 26S proteasome in Saccharomyces cerevisiae and plays a nonessential, substrate-specific role in protein turnover.

21 January 2018

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Structure of 20S proteasome from yeast at 2.4 A resolution

21 January 2018

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The base of the proteasome regulatory particle exhibits chaperone-like activity

21 January 2018

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A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae

21 January 2018

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21 January 2018

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21 January 2018

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Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

21 January 2018

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

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Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

21 January 2018

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Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels

21 January 2018

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A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit

21 January 2018

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Structural motifs involved in ubiquitin-mediated processing of the NF-kappaB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domain

21 January 2018

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NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

21 January 2018

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Coordinated induction of the ubiquitin conjugation pathway accompanies the developmentally programmed death of insect skeletal muscle

21 January 2018

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p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

21 January 2018

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Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway.

21 January 2018

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Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae

21 January 2018

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Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway

21 January 2018

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The spectrum of mutations in UBE3A causing Angelman syndrome

21 January 2018

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Correlation between HPV positivity and state of the p53 gene in cervical carcinoma cell lines

21 January 2018

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The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

21 January 2018

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Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

21 January 2018

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The ubiquitin pathway in Parkinson's disease

21 January 2018

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Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein

21 January 2018

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

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A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects

21 January 2018

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A proteolytic pathway that recognizes ubiquitin as a degradation signal

21 January 2018

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Degradation of CFTR by the ubiquitin-proteasome pathway

21 January 2018

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Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.

21 January 2018

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The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate

21 January 2018

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Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha

21 January 2018

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Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states

21 January 2018

0 references

E2/E3-mediated assembly of lysine 29-linked polyubiquitin chains

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Growth hormone effects on RNA and protein synthesis in liver

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Regulation of ubiquitin-dependent processes by deubiquitinating enzymes

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Ubiquitin and the control of protein fate in the secretory and endocytic pathways

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The ‘second-codon rule’ and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes

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Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70

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Identifiers

DOI

10.1002/(SICI)1521-1878(200005)22:5<442::AID-BIES6>3.0.CO;2-Q

1 reference

30 July 2017

1 reference