(Q33916550)

30 July 2017

title

T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection (English)

1 reference

30 July 2017

0 references

1 reference

Johanna Tauriainen

2

0 references

Takuya Yamamoto

Takuya Yamamoto

3

0 references

Marcus Buggert

Marcus Buggert

1

0 references

Ole Lund

Ole Lund

7

0 references

Marianne Jansson

9

Marianne Jansson

1 reference

30 July 2017

10

Anders Sönnerborg

1 reference

30 July 2017

11

Richard A Koup

1 reference

30 July 2017

6

Jakob Michaëlsson

1 reference

30 July 2017

Martin A Ivarsson

5

1 reference

ORCID Public Data File 2021

Michael R. Betts

12

Michael R Betts

1 reference

30 July 2017

Juliet Frederiksen

4

1 reference

30 July 2017

Bo Hejdeman

8

1 reference

30 July 2017

Annika C Karlsson

13

1 reference

30 July 2017

publication date

17 July 2014

1 reference

30 July 2017

1 reference

30 July 2017

volume

10

1 reference

30 July 2017

issue

7

1 reference

30 July 2017

page(s)

e1004251

1 reference

Creative Commons CC0 License

30 July 2017

copyright license

start time

17 July 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

cites work

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Multiparametric bioinformatics distinguish the CD4/CD8 ratio as a suitable laboratory predictor of combined T cell pathogenesis in HIV infection

5 July 2018

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5 July 2018

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5 July 2018

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Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6/TGF-β1 signaling

5 July 2018

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5 July 2018

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Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells

5 July 2018

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Differential localization of T-bet and Eomes in CD8 T cell memory populations.

5 July 2018

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Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

5 July 2018

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Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory.

5 July 2018

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Transcriptional control of effector and memory CD8+ T cell differentiation

5 July 2018

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Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection

5 July 2018

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CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction

5 July 2018

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Characterization of HIV-specific CD4+ T cell responses against peptides selected with broad population and pathogen coverage

5 July 2018

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Combination of immune and viral factors distinguishes low-risk versus high-risk HIV-1 disease progression in HLA-B*5701 subjects

5 July 2018

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Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

5 July 2018

1 reference

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Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

5 July 2018

1 reference

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Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

5 July 2018

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Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection

5 July 2018

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Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

5 July 2018

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5 July 2018

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Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

High antigen levels are the cause of T cell exhaustion during chronic viral infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Restoring function in exhausted CD8 T cells during chronic viral infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Viral immune evasion due to persistence of activated T cells without effector function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102564

Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004251

The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004251

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004251

Skewed maturation of memory HIV-specific CD8 T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004251

Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004251

Broadly immunogenic HLA class I supertype-restricted elite CTL epitopes recognized in a diverse population infected with different HIV-1 subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004251

Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004251

Immunogenic and tolerogenic signatures in human immunodeficiency virus (HIV)-infected controllers compared with progressors and a conversion strategy of virus control

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004251

HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004251

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004251

Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25032686

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25032686

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25032686

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PPAT.1004251

1 reference

30 July 2017

1 reference

30 July 2017

1 reference