(Q33918201)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

title

Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Jacob M. Hooker

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

14

Joanna S Fowler

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

13

Nora D Volkow

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

7

Florence Wagner

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

3

Lisa Muench

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

4

Alicia Reid

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

8

Edward Holson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

9

Stephen J Haggarty

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

11

Payton King

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

12

Pauline Carter

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

author name string

Young Jun Seo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Shannon Caesar

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Logan Jean

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Philipp Weiss

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Sung Won Kim

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

publication date

21 May 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

ACS Chemical Neuroscience

16 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

page(s)

588-596

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain

16 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Class I HDAC imaging using [ (3)H]CI-994 autoradiography

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal a

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Epigenetics and bacterial infections

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

An epigenetic blockade of cognitive functions in the neurodegenerating brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Phase I-II study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

The synthesis and evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), a PET radiotracer designed for the delineation of histone deacetylase expression in cancer.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Organic synthesis toward small-molecule probes and drugs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Histone deacetylase inhibitor, MS-275, exhibits poor brain penetration: PK studies of [C]MS-275 using Positron Emission Tomography

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Epigenomic disruption: the effects of early developmental exposures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

HDAC2 negatively regulates memory formation and synaptic plasticity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

New predictive models for blood-brain barrier permeability of drug-like molecules

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Epigenetic regulation in psychiatric disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Cancer epigenomics: DNA methylomes and histone-modification maps

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Demystifying brain penetration in central nervous system drug discovery. Miniperspective

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Insights for predicting blood-brain barrier penetration of CNS targeted molecules using QSPR approaches

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102966

Pharmacokinetics and cerebrospinal fluid penetration of CI-994 (N-acetyldinaline) in the nonhuman primate

29 October 2018

1 reference

12 December 2020

Production of [11C]CH3I by single pass reaction of [11C]CH4 with I2

1 reference

12 December 2020

Hydrophobic Effect and Hydrogen Bonds Account for the Improved Activity of a Complement Inhibitor, Compstatin

1 reference

12 December 2020

Synthesis of methyl iodide-11C and formaldehyde-11C

1 reference

12 December 2020

A simple synthesis of [11C]methyl triflate

1 reference

12 December 2020

Acetyldinaline: a new oral cytostatic drug with impressive differential activity against leukemic cells and normal stem cells--preclinical studies in a relevant rat model for human acute myelocytic leukemia

1 reference

12 December 2020

The preparation of a carbon-11 labelled neurohormone--[11C]melatonin

1 reference

12 December 2020

Target practice: HDAC inhibitors for schizophrenia

1 reference

12 December 2020

Identifiers

DOI

10.1021/CN500021P

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

PubMed publication ID

24780082

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24780082%20AND%20SRC:MED&resulttype=core&format=json