(Q33936029)

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Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes

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5 February 2020

Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes (English)

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5 February 2020

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5 February 2020

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5 February 2020

author name string

Jianshe Wang

1

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5 February 2020

Jun Jiang

2

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5 February 2020

Hongxia Zhang

3

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5 February 2020

Junping Wang

4

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5 February 2020

Hua Cai

5

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5 February 2020

Cheng Li

6

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5 February 2020

Kangbai Li

7

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5 February 2020

Jing Liu

8

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5 February 2020

Guangxun Zou

10

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5 February 2020

Dazhi Wang

11

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5 February 2020

Jiayin Dai

13

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5 February 2020

publication date

16 June 2011

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5 February 2020

Molecular & Cellular Proteomics

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5 February 2020

10

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Europe PubMed Central

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5 February 2020

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21685020%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

M111.008748

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21685020%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Metabolic pathways of trichothecenes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Chromatographic assays of drug oxidation by human cytochrome P450 3A4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Proteomics identification of azaspiracid toxin biomarkers in blue mussels, Mytilus edulis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Different apoptotic pathways induced by zearalenone, T-2 toxin and ochratoxin A in human hepatoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

T-2 toxin: incidence and toxicity in poultry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Degradation of trichothecene mycotoxins by chicken intestinal microbes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Report from SCOOP task 3.2.10 "collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states". Subtask: trichothecenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Proteomic study for the cellular responses to Cd2+ in Schizosaccharomyces pombe through amino acid-coded mass tagging and liquid chromatography tandem mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Trichothecenes in the environment: relevance to human health

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Discordant protein and mRNA expression in lung adenocarcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Cytochrome P-450 3A4: regulation and role in drug metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

In vitro and in vivo drug interactions involving human CYP3A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Metabolism and pharmacokinetics of T-2 toxin and related trichothecenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

T-2 metabolites in the excreta of broiler chickens administered 3H-labeled T-2 toxin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

In vitro metabolism of T-2 toxin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Modification of in vitro metabolism of T-2 toxin by esterase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Metabolism of T-2 mycotoxin by cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

The cytochrome P-450-dependent hydroxylation of T-2 toxin in various animal species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Metabolism of trichothecene mycotoxins. I. Microsomal deacetylation of T-2 toxin in animal tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Chapter 4 Preparation of Isolated Rat Liver Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

5 July 2018

Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

29 October 2018

Subclinical doses of T-2 toxin impair acquired immune response and liver cytochrome P450 in pigs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

29 October 2018

Regulation of peroxisome proliferator-activated receptor-gamma in liver fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

29 October 2018

Natural occurrence of 16 fusarium toxins in grains and feedstuffs of plant origin from Germany

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

29 October 2018

Determination of 12 type A and B trichothecenes in cereals by liquid chromatography-electrospray ionization tandem mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

29 October 2018

Immunopathological effect of the mycotoxins cyclopiazonic acid and T-2 toxin on broiler chicken

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

29 October 2018

Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

29 October 2018

Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

29 October 2018

Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

29 October 2018

Reduced early alcohol-induced liver injury in CD14-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

29 October 2018

Mapping of porcine genes belonging to two different cytochrome P450 subfamilies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186201

29 October 2018

The effects of T-2 toxin exposure on liver drug metabolizing enzymes in rabbit

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathway studio—the analysis and navigation of molecular networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of trichothecene mycotoxins. II. Substrate specificity of microsomal deacetylation of trichothecenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of T-2 toxin by rat liver carboxylesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of three trichothecene mycotoxins, T-2 toxin, diacetoxyscirpenol and deoxynivalenol, by bovine rumen microorganisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of some metabolites of T-2 toxin, diacetoxyscirpenol and deoxynivalenol by thermospray high-performance liquid chromatography-mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of multiple cell membrane functions in L-6 myoblasts by T-2 toxin: an important mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of intestinal microflora in the metabolism of trichothecene mycotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative effects of T-2 toxin and diacetoxyscirpenol on drug metabolizing enzymes in rat tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of antioxidants against free radical-mediated lipid peroxidation induced by DON or T-2 toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue inhibitor of metalloproteinase-1 in the liver of patients with chronic liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: comparison with other hepatic cellular models

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21685020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/MCP.M111.008748

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21685020%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21685020%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21685020%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

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