(Q41855885)

13 October 2017

Chromatographic assays of drug oxidation by human cytochrome P450 3A4 (English)

1 reference

13 October 2017

3

F Peter Guengerich

1 reference

13 October 2017

Christal D Sohl

1

1 reference

PMC publication ID

3883453

13 October 2017

Qian Cheng

series ordinal

2

1 reference

13 October 2017

6 August 2009

1 reference

13 October 2017

1 reference

13 October 2017

4

1 reference

13 October 2017

9

1 reference

13 October 2017

1252-1257

1 reference

https://scigraph.springernature.com/pub.10.1038/nprot.2009.122

13 October 2017

0 references

cites work

Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Analytical tools and approaches for metabolite identification in early drug discovery

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Structural basis for ligand promiscuity in cytochrome P450 3A4.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Predicting in vivo drug interactions from in vitro drug discovery data

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Monitoring enzymatic conversions by mass spectrometry: a critical review

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Genetic contribution to variable human CYP3A-mediated metabolism

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Metabolic characterization of the major human small intestinal cytochrome p450s

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Testosterone 1 beta-hydroxylation by human cytochrome P450 3A4.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Cytochromes P450, drugs, and diseases

18 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2009.122

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3883453

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

2 December 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2009.122

Rapid quantitation of testosterone hydroxyl metabolites by ultra-performance liquid chromatography and mass spectrometry

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2009.122

43 Measurement of steroid hydroxylation reactions by high-performance liquid chromatography as indicator of P450 identity and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2009.122

Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2009.122

31 March 2020

Identifiers

DOI

10.1038/NPROT.2009.122

1 reference

13 October 2017

1 reference

PMC publication ID

3883453

13 October 2017

PubMed publication ID

19661995

1 reference

PMC publication ID

3883453