(Q33940330)

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Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products

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scholarly article

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Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products (English)

1 reference

Europe PubMed Central

30 July 2017

author name string

N Isakov

1

1 reference

Europe PubMed Central

30 July 2017

B Biesinger

2

1 reference

Europe PubMed Central

30 July 2017

language of work or name

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publication date

1 June 2000

1 reference

Europe PubMed Central

30 July 2017

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Europe PubMed Central

30 July 2017

267

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Europe PubMed Central

30 July 2017

3413-3421

1 reference

Europe PubMed Central

30 July 2017

12

1 reference

Europe PubMed Central

30 July 2017

Signal transduction by lymphocyte antigen receptors

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Three-dimensional segregation of supramolecular activation clusters in T cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The immunological synapse: a molecular machine controlling T cell activation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Physical association of the cytoplasmic domain of CD2 with the tyrosine kinases p56lck and p59fyn

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Both T cell receptor (TcR)-CD3 complex and CD2 increase the tyrosine kinase activity of p56lck. CD2 can mediate TcR-CD3-independent and CD45-dependent activation of p56lck

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

A signaling pathway governing early thymocyte maturation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Regulation of thymocyte development through CD3: functional dissociation between p56lck and CD3 sigma in early thymic selection.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Myristylation and palmitylation of Src family members: the fats of the matter

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Structural basis for the binding of proline-rich peptides to SH3 domains

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Biochemical analysis of the CD45-p56(lck) complex in Jurkat T cells lacking expression of lymphocyte phosphatase-associated phosphoprotein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Interleukin-7 activates p56lck and p59fyn, two tyrosine kinases associated with the p90 interleukin-7 receptor in primary human T cells.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Ras GTPase-activating protein: a substrate and a potential binding protein of the protein-tyrosine kinase p56lck

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

A 32-kD GTP-binding protein associated with the CD4-p56lck and CD8-p56lck T cell receptor complexes

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

A Raf-1-related p110 polypeptide associates with the CD4-p56lck complex in T cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

p56lck interacts via its src homology 2 domain with the ZAP-70 kinase

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Interaction between lck and syk family tyrosine kinases in Fc gamma receptor-initiated activation of natural killer cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Crystal structure of the Src family tyrosine kinase Hck

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Stable growth transformation of human T lymphocytes by herpesvirus saimiri

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Persistence of Selectable Herpesvirus Saimiri in Various Human Haematopoietic and Epithelial Cell Lines

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

CD2-mediated autocrine growth of herpes virus saimiri-transformed human T lymphocytes

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Transformation of human T-cell clones by Herpesvirus saimiri: intact antigen recognition by autonomously growing myelin basic protein-specific T cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

A region of the Herpesvirus saimiri genome required for oncogenicity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Identification of transforming genes of subgroup A and C strains of Herpesvirus saimiri

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotype

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The product of the Herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

IL-2 independent growth and cytotoxicity of herpesvirus saimiri-infected human CD8 cells and involvement of two open reading frame sequences of the virus

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Association of the viral oncoprotein STP-C488 with cellular ras.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Identification of Lck-binding elements in tip of herpesvirus saimiri

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Selective activation of T cell kinase p56lck by Herpesvirus saimiri protein tip.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Activation of the lck tyrosine-protein kinase by the binding of the tip protein of herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localization

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Primary structure of the Herpesvirus ateles genome

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

DNA tumor viruses and Src family tyrosine kinases, an intimate relationship

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The lymphocyte-specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

The tyrosine kinase activity of p56lck is increased in human T cells activated via CD2

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01412.X

21 January 2018

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10.1046/J.1432-1327.2000.01412.X

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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