(Q33944281)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

0 references

1 reference

5

1 reference

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30 January 2020

Yiguo Hu

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

19

Paul Richardson

1 reference

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30 January 2020

20

Kenneth C Anderson

1 reference

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30 January 2020

7

Hiroshi Ikeda

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

18

Nikhil Munshi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

10

Diana Cirstea

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

15

Madhavi Bandi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

17

Noopur Raje

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

3

Teru Hideshima

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

16

Ruben D Carrasco

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

8

Giada Bianchi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1

Güllü Görgün

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

2

Elisabetta Calabrese

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

13

Sabikun Nahar

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

author name string

Jeffrey Ecsedy

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Mala Mani

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Loredana Santo

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Yu-Tzu Tai

12

1 reference

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30 January 2020

Mei Zheng

14

1 reference

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30 January 2020

language of work or name

English

0 references

publication date

9 April 2010

1 reference

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30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

volume

115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

page(s)

5202-5213

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

issue

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

30 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2892955/fullTextXML

inferred from PubMed Central ID database lookup

cites work

In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Analysis of Aurora kinase A expression in CD34(+) blast cells isolated from patients with myelodysplastic syndromes and acute myeloid leukemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Aurora-A expression is independently associated with chromosomal instability in colorectal cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Discovery and development of aurora kinase inhibitors as anticancer agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Targeting aurora kinases as therapy in multiple myeloma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Aurora A, meiosis and mitosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Mitotic kinases as regulators of cell division and its checkpoints

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

The centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that might benefit from aurora kinase inhibition.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumor cell.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892955

Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity

29 October 2018

1 reference

12 December 2020

Chromosomal analysis in multiple myeloma: cytogenetic evidence of two different diseases

1 reference

12 December 2020

Phospho-regulation of human protein kinase Aurora-A: analysis using anti-phospho-Thr288 monoclonal antibodies

1 reference

12 December 2020

Amplification/overexpression of a mitotic kinase gene in human bladder cancer

1 reference

12 December 2020

A novel mechanism for activation of the protein kinase Aurora A

1 reference

12 December 2020

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

1 reference

12 December 2020

10.1182/BLOOD-2009-12-259523

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20382844%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference