Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q33946771)
Watch
English
Targeting sirtuins for the treatment of diabetes
scientific article
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
title
Targeting sirtuins for the treatment of diabetes
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
author
Frank Huynh
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
Matthew D. Hirschey
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
author name string
Kathleen A Hershberger
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
publication date
1 May 2013
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
published in
Diabetes management
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
volume
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
issue
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
page(s)
245-257
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
cites work
High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Sirtuin biology and relevance to diabetes treatment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Are sirtuins viable targets for improving healthspan and lifespan?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Effects of chronic calorie restriction or dietary resveratrol supplementation on insulin sensitivity markers in a primate, Microcebus murinus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Sirtuins as regulators of metabolism and healthspan
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Metabolic actions of hypothalamic SIRT1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
The sirtuin SIRT6 regulates lifespan in male mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SRT1720 improves survival and healthspan of obese mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Pilot study of resveratrol in older adults with impaired glucose tolerance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
2 references
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
The first identification of lysine malonylation substrates and its regulatory enzyme
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
What is new for an old molecule? Systematic review and recommendations on the use of resveratrol
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Resveratrol attenuates high-fat diet-induced insulin resistance by influencing skeletal muscle lipid transport and subsarcolemmal mitochondrial β-oxidation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT1 is regulated by a PPAR{γ}-SIRT1 negative feedback loop associated with senescence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Distribution analysis of deacetylase SIRT1 in rodent and human nervous systems
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT6 protects against pathological damage caused by diet-induced obesity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Central administration of resveratrol improves diet-induced diabetes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT1 genetic variation is related to BMI and risk of obesity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SirT1 gain of function increases energy efficiency and prevents diabetes in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Resveratrol inhibits nonalcoholic fatty liver disease in rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Sirt1 protects against high-fat diet-induced metabolic damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT6 in DNA repair, metabolism and ageing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT1 transgenic mice show phenotypes resembling calorie restriction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Resveratrol improves health and survival of mice on a high-calorie diet
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
High absorption but very low bioavailability of oral resveratrol in humans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Absorption of three wine-related polyphenols in three different matrices by healthy subjects
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Oral antihyperglycemic therapy for type 2 diabetes: scientific review
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
5 July 2018
Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Transcriptomic and metabonomic profiling reveal synergistic effects of quercetin and resveratrol supplementation in high fat diet fed mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Ameliorative effects of resveratrol on liver injury in streptozotocin-induced diabetic rats.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
The protective effect of resveratrol on islet insulin secretion and morphology in mice on a high-fat diet.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Insulin and resveratrol act synergistically, preventing cardiac dysfunction in diabetes, but the advantage of resveratrol in diabetics with acute heart attack is antagonized by insulin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Association of SIRT1 gene variation with visceral obesity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110209
retrieved
29 October 2018
The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25067957
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
CHEMICAL CONSTITUENTS OF POLYGONACEOUS PLANTS. I. STUDIES ON THE COMPONENTS OF KO-J O-KON. (POLYGONUM CUSPIDATUM SIEB. ET ZUCC.)
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25067957
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25067957
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.2217/DMT.13.6
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
PMC publication ID
4110209
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
PubMed publication ID
25067957
1 reference
stated in
Europe PubMed Central
PMC publication ID
4110209
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25067957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
