(Q33947954)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

title

iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Edel O'Toole

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

David P. Kelsell

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

author name string

Sarah L Etheridge

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Nihal Kaplan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Charlotte Simpson

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Olivier Marches

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Spiro Getsios

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Akemi Ishida-Yamamoto

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

publication date

18 March 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

volume

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

page(s)

4064-4076

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

issue

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

11 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4110483/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Rhomboid proteins: a role in keratinocyte proliferation and cancer.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Influence of interleukin-8 (IL-8) and IL-8 receptors on the migration of human keratinocytes, the role of PLC-γ and potential clinical implications.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

EphA2/Ephrin-A1 signaling complexes restrict corneal epithelial cell migration.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Cell-cell connectivity: desmosomes and disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Brief treatment with heparin-binding EGF-like growth factor, but not with EGF, is sufficient to accelerate epithelial wound healing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Targeting the human EGFR family in esophagogastric cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Increased expression of Dsg2 in malignant skin carcinomas: A tissue-microarray based study

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Rhomboid proteases and their biological functions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

The epidermal growth factor receptor system in skin repair and inflammation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Desmoglein-2: a novel regulator of apoptosis in the intestinal epithelium

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Genome-wide gene expression profile analysis of esophageal squamous cell carcinomas

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Diffuse EGFR staining is associated with reduced overall survival in locally advanced oesophageal squamous cell cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Bioactive interleukin-8 is expressed in wounds and enhances wound healing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

28 July 2018

Cutaneous wound healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Temperature sensitivity of the keratin cytoskeleton and delayed spreading of keratinocyte lines derived from EBS patients.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Altered [125I]epidermal growth factor binding and receptor distribution in psoriasis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

TACE is required for fetal murine cardiac development and modeling

28 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

Inflammatory skin and bowel disease linked to ADAM17 deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

Generation and characterization of epidermolysis bullosa simplex cell lines: scratch assays show faster migration with disruptive keratin mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

Amphiregulin-dependent proliferation of cultured human keratinocytes: autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

Growth factors and cytokines in wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

Amphiregulin as a tumor promoter for oral squamous cell carcinoma: involvement of cyclooxygenase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

Interleukin 6 indirectly induces keratinocyte migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

In vivo introduction of the interleukin 6 gene into human keratinocytes: induction of epidermal proliferation by the fully spliced form of interleukin 6, but not by the alternatively spliced form

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

Clinicopathological and prognostic significance of the expression of ADAM17 mRNA and protein in esophageal squamous cell carcinoma

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110483

Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer

29 October 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

A novel in situ method for the detection of deficient transglutaminase activity in the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU120

An essential role for ectodomain shedding in mammalian development

21 January 2018

1 reference

12 December 2020

Enhanced modulation of keratinocyte motility by transforming growth factor-alpha (TGF-alpha) relative to epidermal growth factor (EGF)

1 reference

12 December 2020

Quantitative analysis of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in human skin wounds

1 reference

12 December 2020

Epidermal growth factor receptor overexpression in esophageal carcinoma. An immunohistochemical study correlated with clinicopathologic findings and DNA amplification

1 reference

12 December 2020

Retinoid regulation of heparin-binding EGF-like growth factor gene expression in human keratinocytes and skin

1 reference

12 December 2020

Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17

1 reference

12 December 2020

Cytokine expression profile over time in severely burned pediatric patients

1 reference

12 December 2020

EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus

1 reference

12 December 2020

Further evidence for prognostic significance of epidermal growth factor receptor gene amplification in patients with esophageal squamous cell carcinoma

1 reference

12 December 2020

EGFR enhances early healing after cutaneous incisional wounding

1 reference

12 December 2020

Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas

1 reference

12 December 2020

Overexpression of transforming growth factor alpha in psoriatic epidermis

1 reference

12 December 2020

RNA interference in keratinocytes and an organotypic model of human epidermis

1 reference

12 December 2020

Alteration and significance of heparin-binding epidermal-growth-factor-like growth factor in psoriatic epidermis

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDU120

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24643277%20AND%20SRC:MED&resulttype=core&format=json