(Q33969281)

English

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.

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Europe PubMed Central

PubMed publication ID

30 July 2017

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A. (English)

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Europe PubMed Central

PubMed publication ID

30 July 2017

G protein-coupled receptor

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Saskia Nijmeijer

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Saskia Nijmeijer

4

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Chris de Graaf

2

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author name string

Mark H P Verheij

1

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Europe PubMed Central

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30 July 2017

Gerdien E de Kloe

3

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30 July 2017

Henry F Vischer

5

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30 July 2017

Rogier A Smits

6

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30 July 2017

Obbe P Zuiderveld

7

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Europe PubMed Central

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30 July 2017

Saskia Hulscher

8

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30 July 2017

Linda Silvestri

9

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30 July 2017

Andrew J Thompson

10

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30 July 2017

Jacqueline E van Muijlwijk-Koezen

11

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30 July 2017

Sarah C R Lummis

12

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30 July 2017

Rob Leurs

13

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30 July 2017

Iwan J P de Esch

14

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30 July 2017

language of work or name

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publication date

2 July 2011

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30 July 2017

Bioorganic & Medicinal Chemistry Letters

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30 July 2017

21

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30 July 2017

18

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30 July 2017

5460-5464

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Europe PubMed Central

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30 July 2017

The chemical basis of pharmacology

1 reference

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Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

1 reference

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Molecular determinants of ligand binding to H4R species variants

1 reference

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Customizing G Protein-coupled receptor models for structure-based virtual screening

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Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

1 reference

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Lessons for fragment library design: analysis of output from multiple screening campaigns

1 reference

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1 reference

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Comparison of molecular fingerprint methods on the basis of biological profile data

1 reference

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In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties

1 reference

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A ligand-based approach to mining the chemogenomic space of drugs

1 reference

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Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations

1 reference

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A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.

1 reference

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Integration of fragment screening and library design

1 reference

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Chemogenomic approaches to rational drug design

1 reference

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The 5-HT3 receptor as a therapeutic target

1 reference

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Optimizing fragment and scaffold docking by use of molecular interaction fingerprints

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Library design for fragment based screening

1 reference

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Ligand efficiency: a useful metric for lead selection

1 reference

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The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor.

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A new approach to finding natural chemical structure classes

1 reference

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Molecular complexity and its impact on the probability of finding leads for drug discovery

1 reference

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Property distribution of drug-related chemical databases.

1 reference

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Nothing to sneeze at.

1 reference

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Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach

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cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia

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29 October 2018

Identifiers

10.1016/J.BMCL.2011.06.123

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

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