(Q33991188)

30 July 2017

title

Plastid-associated porphobilinogen synthase from Toxoplasma gondii: kinetic and structural properties validate therapeutic potential (English)

1 reference

30 July 2017

0 references

David S Roos

5

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author name string

Dhanasekaran Shanmugam

1

1 reference

30 July 2017

Bo Wu

2

1 reference

30 July 2017

Ursula Ramirez

3

1 reference

30 July 2017

Eileen K Jaffe

4

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30 July 2017

language of work or name

English

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publication date

4 May 2010

1 reference

Journal of Biological Chemistry

30 July 2017

published in

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30 July 2017

volume

285

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30 July 2017

issue

29

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30 July 2017

page(s)

22122-22131

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Structure of the Heme Biosynthetic Pseudomonas aeruginosa Porphobilinogen Synthase in Complex with the Antibiotic Alaremycin

30 July 2017

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1 reference

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5 July 2018

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Probing the oligomeric assemblies of pea porphobilinogen synthase by analytical ultracentrifugation

5 July 2018

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Shape shifting leads to small-molecule allosteric drug discovery

5 July 2018

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5 July 2018

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Inference of macromolecular assemblies from crystalline state

5 July 2018

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ALAD porphyria is a conformational disease

5 July 2018

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5 July 2018

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5 July 2018

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Substrate-induced interconversion of protein quaternary structure isoforms

5 July 2018

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Rhodobacter capsulatus porphobilinogen synthase, a high activity metal ion independent hexamer

5 July 2018

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5 July 2018

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Enzymes for heme biosynthesis are found in both the mitochondrion and plastid of the malaria parasite Plasmodium falciparum

5 July 2018

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A graph-theory algorithm for rapid protein side-chain prediction

5 July 2018

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Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase

5 July 2018

1 reference

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Evaluating conformational free energies: the colony energy and its application to the problem of loop prediction

5 July 2018

1 reference

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Processing of an apicoplast leader sequence in Plasmodium falciparum and the identification of a putative leader cleavage enzyme

5 July 2018

1 reference

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Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid

5 July 2018

1 reference

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Regulatory network of tetrapyrrole biosynthesis--studies of intracellular signalling involved in metabolic and developmental control of plastids

5 July 2018

1 reference

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The x-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with substrate and three inhibitors

5 July 2018

1 reference

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The X-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with two diacid inhibitors

5 July 2018

1 reference

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Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity

5 July 2018

1 reference

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Porphobilinogen synthase from pea: expression from an artificial gene, kinetic characterization, and novel implications for subunit interactions.

5 July 2018

1 reference

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The porphobilinogen synthase family of metalloenzymes.

5 July 2018

1 reference

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Origin, targeting, and function of the apicomplexan plastid

5 July 2018

1 reference

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Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

5 July 2018

1 reference

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Consensus sequence of translational initiation sites from Toxoplasma gondii genes

5 July 2018

1 reference

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Comparative studies on the 5-aminolaevulinic acid dehydratases from Pisum sativum, Escherichia coli and Saccharomyces cerevisiae

5 July 2018

1 reference

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Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii

5 July 2018

1 reference

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Porphobilinogen synthase, the first source of Heme's asymmetry

5 July 2018

1 reference

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Heme synthesizing enzymes of Plasmodium knowlesi: a simian malaria parasite.

5 July 2018

1 reference

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Delta-aminolevulinic acid dehydratase from Plasmodium falciparum: indigenous versus imported.

21 January 2018

1 reference

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Amino-terminal control of transgenic protein expression levels in Toxoplasma gondii

21 January 2018

1 reference

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Bradyrhizobium japonicum porphobilinogen synthase uses two Mg(II) and monovalent cations.

21 January 2018

1 reference

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Inhibition of delta-aminolevulinic acid dehydrase by 4,6-dioxoheptanoic acid

21 January 2018

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12 December 2020

Characterization of the role of the stimulatory magnesium of Escherichia coli porphobilinogen synthase

1 reference

12 December 2020

Heme biosynthesis by the malarial parasite. Import of delta-aminolevulinate dehydrase from the host red cell

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12 December 2020

Pseudomonas aeruginosa contains a novel type V porphobilinogen synthase with no required catalytic metal ions

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12 December 2020

Synthesis of bisubstrate inhibitors of porphobilinogen synthase from Pseudomonas aeruginosa

1 reference

12 December 2020

Kinetics and thermodynamics of the interchange of the morpheein forms of human porphobilinogen synthase

1 reference

12 December 2020

Inhibition of Escherichia coli porphobilinogen synthase using analogs of postulated intermediates

1 reference

12 December 2020

An unusual phylogenetic variation in the metal ion binding sites of porphobilinogen synthase

1 reference

12 December 2020

de novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.107243

1 reference

30 July 2017

1 reference

30 July 2017

1 reference