(Q33998979)

30 July 2017

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title

Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications (English)

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Christos Socrates Mantzoros

30 July 2017

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series ordinal

2

object named as

Christos S Mantzoros

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30 July 2017

Aoife M Brennan

1

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30 July 2017

language of work or name

1 reference

1 June 2006

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Nature Clinical Practice Endocrinology and Metabolism

30 July 2017

published in

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30 July 2017

volume

2

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30 July 2017

issue

6

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30 July 2017

page(s)

318-327

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https://scigraph.springernature.com/pub.10.1038/ncpendmet0196

30 July 2017

exact match

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cites work

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Effects of intracerebroventricular infusion of leptin in obese Zucker rats.

21 January 2018

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Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia

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Positional cloning of the mouse obese gene and its human homologue

21 January 2018

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7 January 2021

Leptin and the regulation of body weight in mammals

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7 January 2021

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Crystal structure of the obese protein leptin-E100

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Human leptin levels are pulsatile and inversely related to pituitary-adrenal function.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Abnormal splicing of the leptin receptor in diabetic mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Expression of leptin receptor isoforms in rat brain microvessels

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Diabetes, obesity, and the brain

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Rapid rewiring of arcuate nucleus feeding circuits by leptin.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin resistance - or why leptin fails to work in obesity

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Overweight humans are resistant to the weight-reducing effects of melanocortin4-10.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Lipodystrophies: rare disorders causing metabolic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Life without white fat: a transgenic mouse

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin is a potent stimulator of bone growth in ob/ob mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: Impact on differentiation markers, apoptosis, and osteoclastic signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin regulates bone formation via the sympathetic nervous system

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Obesity-associated hypertension: new insights into mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Recombinant human leptin in women with hypothalamic amenorrhea.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Role of leptin in the neuroendocrine response to fasting

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin alters the response of the growth hormone releasing factor- growth hormone--insulin-like growth factor-I axis to fasting.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Basal corticosterone levels of young og/ob mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin Regulates Functional Capacities of Polymorphonuclear Neutrophils

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with r

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Monogenic obesity in humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Effect of dietary restraint during and following pegylated recombinant leptin (PEG-OB) treatment of overweight men

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin-replacement therapy for lipodystrophy.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Long-term efficacy of leptin replacement in patients with generalized lipodystrophy

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Long-term leptin-replacement therapy for lipoatrophic diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Cardiovascular risk and body-fat abnormalities in HIV-infected adults

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Leptin-induced signal transduction pathways.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Intracellular signal transduction pathways induced by leptin in C2C12 cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0196

7 January 2021

Identifiers

DOI

10.1038/NCPENDMET0196

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Dimensions Publication ID

30 July 2017

1019716419

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1 reference