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Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa

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Europe PubMed Central

2 August 2017

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Europe PubMed Central

Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa (English)

1 reference

Europe PubMed Central

2 August 2017

anorexia nervosa

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Christos Socrates Mantzoros

2

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Christos S Mantzoros

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Europe PubMed Central

2 August 2017

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Jean L Chan

1

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Europe PubMed Central

2 August 2017

language of work or name

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publication date

1 July 2005

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Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

366

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Europe PubMed Central

2 August 2017

9479

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Europe PubMed Central

2 August 2017

74-85

1 reference

Europe PubMed Central

2 August 2017

Positional cloning of the mouse obese gene and its human homologue

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Serum immunoreactive-leptin concentrations in normal-weight and obese humans

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Role of leptin in the neuroendocrine response to fasting

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The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

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Human leptin levels are pulsatile and inversely related to pituitary-adrenal function.

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Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects

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Circadian and ultradian variations of leptin in normal man under continuous enteral nutrition: relationship to sleep and body temperature.

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STAT3 signalling is required for leptin regulation of energy balance but not reproduction

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In vitro stimulation of the prepubertal rat gonadotropin-releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms.

1 reference

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Expression of a leptin receptor in immortalized gonadotropin-releasing hormone-secreting neurons

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Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

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Leptin treatment rescues the sterility of genetically obese ob/ob males

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

1 reference

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1 reference

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Slowing of pulsatile luteinizing hormone secretion in men after forty-eight hours of fasting.

1 reference

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The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin

1 reference

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Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus.

1 reference

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Regulation of in vivo TSH secretion by leptin

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Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans

1 reference

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Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones

1 reference

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Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress

1 reference

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inferred from DOI database lookup

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1 reference

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Leptin alters the response of the growth hormone releasing factor- growth hormone--insulin-like growth factor-I axis to fasting.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Defects in pulsatile LH release in normally menstruating runners

1 reference

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based on heuristic

inferred from DOI database lookup

Altered neuroendocrine regulation of gonadotropin secretion in women distance runners

1 reference

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inferred from DOI database lookup

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1 reference

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1 reference

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inferred from DOI database lookup

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1 reference

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inferred from DOI database lookup

Female hypogonadotropic hypogonadism. Hypothalamic amenorrhea syndrome.

1 reference

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inferred from DOI database lookup

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1 reference

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1 reference

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based on heuristic

inferred from DOI database lookup

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1 reference

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based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Increased cortisol production in women runners

1 reference

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7 January 2021

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inferred from DOI database lookup

Abnormal cortisol secretion and responses to corticotropin-releasing hormone in women with hypothalamic amenorrhea.

1 reference

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1 reference

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inferred from DOI database lookup

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1 reference

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inferred from DOI database lookup

Functional hypothalamic amenorrhea: hypoleptinemia and disordered eating

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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based on heuristic

inferred from DOI database lookup

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1 reference

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1 reference

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based on heuristic

inferred from DOI database lookup

Review of the prevalence and incidence of eating disorders

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Plasma concentrations of obese protein in anorexia nervosa

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin in relation to resumption of menses in women with anorexia nervosa.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypoleptinaemia in patients with anorexia nervosa and in elite gymnasts with anorexia athletica

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Diurnal variation of the serum leptin concentration in patients with anorexia nervosa.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypoleptinemia in patients with anorexia nervosa: loss of circadian rhythm and unresponsiveness to short-term refeeding.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Body fat, caloric intake, and plasma leptin levels in women with anorexia nervosa.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Basal metabolic rate in anorexia nervosa: relation to body composition and leptin concentrations

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Menstrual status and serum leptin levels in anorectic and in menstruating women with low body mass indexes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The role of leptin in the etiopathogenesis of anorexia nervosa and bulimia

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Soluble leptin receptor levels in patients with anorexia nervosa

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Circulating Soluble Leptin Receptor and Free Leptin Index during Childhood, Puberty, and Adolescence

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Recombinant human leptin in women with hypothalamic amenorrhea.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Serum immunoreactive leptin concentrations in patients with anorexia nervosa before and after partial weight recovery

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Serum leptin and gonadotropin levels in patients with anorexia nervosa during weight gain

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Longitudinal changes of circadian leptin, insulin and cortisol plasma levels and their correlation during refeeding in patients with anorexia nervosa

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Serum leptin monitoring in anorectic patients during refeeding therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The effect of therapeutically induced weight gain on plasma leptin levels in patients with anorexia nervosa

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

High serum leptin levels subsequent to weight gain predict renewed weight loss in patients with anorexia nervosa

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Low leptin levels predict amenorrhea in underweight and eating disordered females

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Reproductive function during weight gain in anorexia nervosa. Leptin represents a metabolic gate to gonadotropin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Bone mineral content of amenorrheic and eumenorrheic athletes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Low bone mass density at multiple skeletal sites, including the appendicular skeleton in amenorrheic runners.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Low bone density is an etiologic factor for stress fractures in athletes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Bone mineral loss in young women with amenorrhoea

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Scoliosis and fractures in young ballet dancers. Relation to delayed menarche and secondary amenorrhea

1 reference

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based on heuristic

inferred from DOI database lookup

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based on heuristic

inferred from DOI database lookup

Osteoporosis in anorexia nervosa: prevention and treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Reduced bone mineral in patients with eating disorders

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin: cutting the fat off the bone

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin acts as a growth factor on the chondrocytes of skeletal growth centers

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: Impact on differentiation markers, apoptosis, and osteoclastic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin is a potent stimulator of bone growth in ob/ob mice

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin reduces ovariectomy-induced bone loss in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Serum leptin level is a regulator of bone mass

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Plasma leptin values in relation to bone mass and density and to dynamic biochemical markers of bone resorption and formation in postmenopausal women

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Does leptin have an effect on bone in adult women?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Plasma leptin concentrations in postmenopausal women with osteoporosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Relationship of serum leptin concentration with bone mineral density in the United States population.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Relationship of leptin to bone mineralization in children and adolescents

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of subcutaneous leptin replacement therapy on bone metabolism in patients with generalized lipodystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Use of hormone replacement therapy to reduce the risk of osteopenia in adolescent girls with anorexia nervosa.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Bone mineral changes in young women with hypothalamic amenorrhea treated with oral contraceptives, medroxyprogesterone, or placebo over 12 months

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Osteoporosis in anorexia nervosa: the influence of peak bone density, bone loss, oral contraceptive use, and exercise.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of treatment on established osteoporosis in young women with amenorrhoea

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Irreversible bone loss in former amenorrheic athletes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2966830-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0140-6736(05)66830-4

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

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