(Q34006481)

English

Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21880149%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21880149%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

cell differentiation

1 reference

based on heuristic

inferred from title

Patrick Collombat

2

1 reference

Europe PubMed Central

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11 February 2020

4

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Europe PubMed Central

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11 February 2020

author name string

Simon Kordowich

1

1 reference

Europe PubMed Central

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11 February 2020

Ahmed Mansouri

3

1 reference

Europe PubMed Central

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11 February 2020

publication date

31 August 2011

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Europe PubMed Central

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11 February 2020

BMC Developmental Biology

1 reference

Europe PubMed Central

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11 February 2020

11

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11 February 2020

52

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Europe PubMed Central

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11 February 2020

https://scigraph.springernature.com/pub.10.1186/1471-213x-11-52

0 references

Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Nkx2.2 activates the ghrelin promoter in pancreatic islet cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Islet formation during the neonatal development in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

An illustrated review of early pancreas development in the mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Sox9 coordinates a transcriptional network in pancreatic progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Nkx2.2 regulates beta-cell function in the mature islet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

SOX9 is required for maintenance of the pancreatic progenitor cell pool

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Ghrelin--a hormone with multiple functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Opposing actions of Arx and Pax4 in endocrine pancreas development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Notch signalling controls pancreatic cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Pax6 and Cdx2/3 form a functional complex on the rat glucagon gene promoter G1-element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Insulin-promoter-factor 1 is required for pancreas development in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

IPF1, a homeodomain-containing transactivator of the insulin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

5 July 2018

Genetic determinants of pancreatic epsilon-cell development.

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-52

21 January 2018

Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate.

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-52

21 January 2018

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179930

29 October 2018

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-52

21 January 2018

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-52

21 January 2018

Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis of peri-islet Schwann cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21880149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of somatostatin on exocrine pancreas evaluated on a total external pancreatic fistula of neoplastic origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21880149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/21880149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21880149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An ultrastructural analysis of the developing embryonic pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21880149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic polypeptide, glucagon and insulin secretion from the isolated perfused canine pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21880149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1471-213X-11-52

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21880149%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21880149%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21880149%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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