(Q34019810)

30 July 2017

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title

What recent ribosome structures have revealed about the mechanism of translation (English)

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30 July 2017

Venkatraman Ramakrishnan

series ordinal

2

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30 July 2017

T Martin Schmeing

1

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PubMed ID

19838167

30 July 2017

language of work or name

English

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publication date

18 October 2009

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30 July 2017

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30 July 2017

461

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30 July 2017

7268

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30 July 2017

1234-1242

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https://scigraph.springernature.com/pub.10.1038/nature08403

30 July 2017

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cites work

Study of the structural dynamics of the E coli 70S ribosome using real-space refinement

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12 December 2020

Stimulation of the GTPase Activity of Translation Elongation Factor G by Ribosomal Protein L7/12

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12 December 2020

The G2447A mutation does not affect ionization of a ribosomal group taking part in peptide bond formation

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12 December 2020

Release of peptide promoted by the GGQ motif of class 1 release factors regulates the GTPase activity of RF3.

1 reference

12 December 2020

Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

1 reference

12 December 2020

Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus

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12 December 2020

GTP hydrolysis by IF2 guides progression of the ribosome into elongation

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12 December 2020

The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution

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12 December 2020

Binding of the 3' terminus of tRNA to 23S rRNA in the ribosomal exit site actively promotes translocation

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12 December 2020

Donor site of ribosomal peptidyltransferase: investigation of substrate specificity using 2'(3')-O-(N-acylaminoacyl)dinucleoside phosphates as models of the 3' terminus of N-acylaminoacyl transfer ribonucleic acid

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12 December 2020

Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression

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12 December 2020

Coupling of ribosomal L1 stalk and tRNA dynamics during translation elongation

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12 December 2020

Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon

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12 December 2020

Kinetic Checkpoint at a Late Step in Translation Initiation

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12 December 2020

High resolution structure of the large ribosomal subunit from a mesophilic eubacterium

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12 December 2020

Recognition of cognate transfer RNA by the 30S ribosomal subunit

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12 December 2020

The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis

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12 December 2020

Structure of the Escherichia coli ribosomal termination complex with release factor 2

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12 December 2020

The structural basis of ribosome activity in peptide bond synthesis

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12 December 2020

Substrate-assisted catalysis of peptide bond formation by the ribosome

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12 December 2020

The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA

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12 December 2020

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

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12 December 2020

The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity

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12 December 2020

Translational termination in Escherichia coli: three bases following the stop codon crosslink to release factor 2 and affect the decoding efficiency of UGA-containing signals

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12 December 2020

A posttermination ribosomal complex is the guanine nucleotide exchange factor for peptide release factor RF3.

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12 December 2020

Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome.

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12 December 2020

Ribosome structure and the mechanism of translation

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12 December 2020

An active role for tRNA in decoding beyond codon:anticodon pairing

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12 December 2020

Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome

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12 December 2020

Visualization of elongation factor G on the Escherichia coli 70S ribosome: the mechanism of translocation

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12 December 2020

Mononucleotide derivatives as ribosomal P-site substrates reveal an important contribution of the 2'-OH to activity

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12 December 2020

The antibiotic viomycin traps the ribosome in an intermediate state of translocation.

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12 December 2020

An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA.

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12 December 2020

GTPase activation of elongation factors Tu and G on the ribosome

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12 December 2020

Locking and unlocking of ribosomal motions

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12 December 2020

A single adenosine with a neutral pKa in the ribosomal peptidyl transferase center

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12 December 2020

The kinetics of ribosomal peptidyl transfer revisited

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12 December 2020

Identification of two distinct hybrid state intermediates on the ribosome

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12 December 2020

Identification of molecular interactions between P-site tRNA and the ribosome essential for translocation

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12 December 2020

The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State

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12 December 2020

The translational fidelity function of IF3 during transition from the 30 S initiation complex to the 70 S initiation complex

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12 December 2020

Specificity of RNA-RNA helix recognition

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12 December 2020

Labeling the peptidyltransferase center of the Escherichia coli ribosome with photoreactive tRNA(Phe) derivatives containing azidoadenosine at the 3' end of the acceptor arm: a model of the tRNA-ribosome complex

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12 December 2020

A protein component at the heart of an RNA machine: the importance of protein l27 for the function of the bacterial ribosome

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12 December 2020

Fidelity of aminoacyl-tRNA selection on the ribosome: kinetic and structural mechanisms

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12 December 2020

Novel roles for classical factors at the interface between translation termination and initiation

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12 December 2020

Selection of tRNA by the ribosome requires a transition from an open to a closed form

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12 December 2020

Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosome

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12 December 2020

Intact aminoacyl-tRNA is required to trigger GTP hydrolysis by elongation factor Tu on the ribosome

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12 December 2020

An elongation factor G-induced ribosome rearrangement precedes tRNA-mRNA translocation

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12 December 2020

Two distinct components of release factor function uncovered by nucleophile partitioning analysis

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12 December 2020

Kinetic determinants of high-fidelity tRNA discrimination on the ribosome

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12 December 2020

Role of Elongation Factor G and a Protein Factor on the Release of Ribosomes from Messenger Ribonucleic Acid

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12 December 2020

Structure of the 30S ribosomal subunit

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12 December 2020

GTPase activation of elongation factor EF-Tu by the ribosome during decoding

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12 December 2020

A tripeptide 'anticodon' deciphers stop codons in messenger RNA.

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12 December 2020

A signal relay between ribosomal protein S12 and elongation factor EF-Tu during decoding of mRNA.

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12 December 2020

The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release

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12 December 2020

Structural insights on the translation initiation complex: ghosts of a universal initiation complex

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12 December 2020

Ribosomal protein S12 and ‘non-enzymatic’ translocation

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12 December 2020

Induced fit in initial selection and proofreading of aminoacyl-tRNA on the ribosome

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12 December 2020

RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors

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12 December 2020

Intermediate states in the movement of transfer RNA in the ribosome

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12 December 2020

Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors

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12 December 2020

Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction

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12 December 2020

Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: functional implications

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12 December 2020

Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson-Crick base pairs

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12 December 2020

Role of ribosomal protein L27 in peptidyl transfer

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12 December 2020

Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1

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12 December 2020

The essential role of the invariant GGQ motif in the function and stability in vivo of bacterial release factors RF1 and RF2

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12 December 2020

Rapid peptide bond formation on isolated 50S ribosomal subunits

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12 December 2020

The pretranslocation ribosome is targeted by GTP-bound EF-G in partially activated form

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12 December 2020

Orientation of ribosome recycling factor in the ribosome from directed hydroxyl radical probing.

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12 December 2020

Rapid kinetic analysis of EF-G-dependent mRNA translocation in the ribosome

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12 December 2020

Structures of the bacterial ribosome at 3.5 A resolution

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12 December 2020

Crystal structure of the ribosome recycling factor bound to the ribosome

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12 December 2020

A ratchet-like inter-subunit reorganization of the ribosome during translocation

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12 December 2020

What are the roles of substrate-assisted catalysis and proximity effects in peptide bond formation by the ribosome?

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12 December 2020

Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit

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12 December 2020

Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit

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12 December 2020

How initiation factors maximize the accuracy of tRNA selection in initiation of bacterial protein synthesis.

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12 December 2020

Structure of ratcheted ribosomes with tRNAs in hybrid states

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12 December 2020

Late events of translation initiation in bacteria: a kinetic analysis

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12 December 2020

Ribosomal Proteins S12 and S13 Function as Control Elements for Translocation of the mRNA:tRNA Complex

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12 December 2020

Crystal structure of the ribosome at 5.5 A resolution

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12 December 2020

Structural basis for translation termination on the 70S ribosome

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12 December 2020

Structure of the 30S translation initiation complex.

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12 December 2020

Crystal structure of a translation termination complex formed with release factor RF2

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12 December 2020

Structural insights into peptide bond formation

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12 December 2020

Single amino acid substitution in prokaryote polypeptide release factor 2 permits it to terminate translation at all three stop codons

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12 December 2020

A hierarchical model for evolution of 23S ribosomal RNA.

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12 December 2020

Ribosome release factor RF4 and termination factor RF3 are involved in dissociation of peptidyl-tRNA from the ribosome

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12 December 2020

Kinetically competent intermediates in the translocation step of protein synthesis

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12 December 2020

tRNA selection and kinetic proofreading in translation

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12 December 2020

Specific interaction between the ribosome recycling factor and the elongation factor G from Mycobacterium tuberculosis mediates peptidyl-tRNA release and ribosome recycling in Escherichia coli

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12 December 2020

A quantitative kinetic scheme for 70 S translation initiation complex formation

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12 December 2020

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

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12 December 2020

The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis

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12 December 2020

Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome.

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12 December 2020

The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis.

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12 December 2020

Spontaneous intersubunit rotation in single ribosomes.

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12 December 2020

Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex

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12 December 2020

Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies

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12 December 2020

Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.

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12 December 2020

Structure of the L1 protuberance in the ribosome

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12 December 2020

Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements

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12 December 2020

The cryo-EM structure of a translation initiation complex from Escherichia coli

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12 December 2020

Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

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12 December 2020

Identification of a ribosomal protein essential for peptidyl transferase activity

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12 December 2020

Large-scale movement of elongation factor G and extensive conformational change of the ribosome during translocation

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12 December 2020

Mechanism of peptide bond synthesis on the ribosome

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12 December 2020

Crystal structure of an initiation factor bound to the 30S ribosomal subunit

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12 December 2020

mRNA helicase activity of the ribosome

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12 December 2020

Sequence of steps in ribosome recycling as defined by kinetic analysis.

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12 December 2020

Peptide bond formation does not involve acid-base catalysis by ribosomal residues

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12 December 2020

Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation

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12 December 2020

Quality control by the ribosome following peptide bond formation

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12 December 2020

Structure of the 70S ribosome complexed with mRNA and tRNA

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12 December 2020

Peptide-bond synthesis on the ribosome: no free vicinal hydroxy group required on the terminal ribose residue of peptidyl-tRNA.

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12 December 2020

Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin

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12 December 2020

Stop codon recognition by release factors induces structural rearrangement of the ribosomal decoding center that is productive for peptide release

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12 December 2020

Isomeric phenylalanyl-tRNAs. Position of the aminoacyl moiety during protein biosynthesis

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12 December 2020

Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide

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12 December 2020

X-ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit

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12 December 2020

Structural insights into translational fidelity

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12 December 2020

Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy

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12 December 2020

The ribosome as an entropy trap

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12 December 2020

Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

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12 December 2020

A cryo-electron microscopic study of ribosome-bound termination factor RF2

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12 December 2020

Heptameric (L12)6/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria.

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12 December 2020

A post-translational modification in the GGQ motif of RF2 from Escherichia coli stimulates termination of translation

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12 December 2020

Binding of aminoacyl-tRNA to reconstituted subparticles of Escherichia coli large ribosomal subunits

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12 December 2020

tRNA dynamics on the ribosome during translation

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12 December 2020

Identifiers

DOI

10.1038/NATURE08403

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30 July 2017

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PubMed ID

19838167