(Q34020315)

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A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent (English)

1 reference

Europe PubMed Central

30 July 2017

Rachel F Tyndale

5

object named as

Rachel F Tyndale

1 reference

Europe PubMed Central

30 July 2017

author name string

Man Ki Ho

1

1 reference

Europe PubMed Central

30 July 2017

Jill C Mwenifumbo

2

1 reference

Europe PubMed Central

30 July 2017

Bin Zhao

3

1 reference

Europe PubMed Central

30 July 2017

Elizabeth M J Gillam

4

1 reference

Europe PubMed Central

30 July 2017

publication date

1 January 2008

1 reference

Europe PubMed Central

30 July 2017

Pharmacogenetics and Genomics

1 reference

Europe PubMed Central

30 July 2017

18

1 reference

Europe PubMed Central

30 July 2017

67-75

1 reference

Europe PubMed Central

30 July 2017

1

1 reference

Europe PubMed Central

30 July 2017

Female sex and oral contraceptive use accelerate nicotine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

Cigarette smoking among adults--United States, 2004.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

PMUT: a web-based tool for the annotation of pathological mutations on proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

Haploview: analysis and visualization of LD and haplotype maps

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

Predicting deleterious amino acid substitutions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

Effects of cigarette smoking and carbon monoxide on nicotine and cotinine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

CYP2A6: a human coumarin 7-hydroxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

Ethnic differences in N-glucuronidation of nicotine and cotinine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

Nicotine metabolism defect reduces smoking.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

5 July 2018

Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Ethnic and racial differences in the smoking-related risk of lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

A novel polymorphism of human CYP2A6 gene CYP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Has there been a delay in the age of regular smoking onset among African Americans?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Do the majority of Asian-American and African-American smokers start as adults?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Lack of association between smoking and CYP2A6 gene polymorphisms in A Japanese population.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Formation of indigo by recombinant mammalian cytochrome P450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Metabolism of nicotine to cotinine studied by a dual stable isotope method.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910083

29 October 2018

Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18216723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18216723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cytochrome P450 2A6 in Escherichia coli: purification, spectral and catalytic characterization, and preparation of polyclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18216723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment of functional human cytochrome P450 monooxygenase systems in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/18216723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18216723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18216723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tobacco use among U.S. racial/ethnic minority groups--African Americans, American Indians and Alaska Natives, Asian Americans and Pacific Islanders, Hispanics. A Report of the Surgeon General. Executive summary

1 reference

https://pubmed.ncbi.nlm.nih.gov/18216723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Twenty one novel single nucleotide polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians

1 reference

https://pubmed.ncbi.nlm.nih.gov/18216723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of human cytochrome P4502A6 in C-oxidation of nicotine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18216723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18216723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine metabolism and intake in black and white smokers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18216723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1097/FPC.0B013E3282F3606E

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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