(Q34024830)

30 July 2017

title

α-Ketoglutarate dehydrogenase: a mitochondrial redox sensor (English)

1 reference

30 July 2017

3

Luke I Szweda

1 reference

30 July 2017

Aaron L McLain

1

1 reference

30 July 2017

Pamela A Szweda

series ordinal

2

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30 July 2017

publication date

29 November 2010

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30 July 2017

published in

Free Radical Research

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30 July 2017

volume

45

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30 July 2017

issue

1

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30 July 2017

page(s)

29-36

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Ohr (organic hydroperoxide resistance protein) possesses a previously undescribed activity, lipoyl-dependent peroxidase

30 July 2017

cites work

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The energy-redox axis in aging and age-related neurodegeneration

5 July 2018

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Down-regulation of mitochondrial acyl carrier protein in mammalian cells compromises protein lipoylation and respiratory complex I and results in cell death

5 July 2018

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Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid

5 July 2018

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S-glutathionylation in protein redox regulation.

5 July 2018

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Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress

5 July 2018

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The role of mitochondria in protection of the heart by preconditioning.

5 July 2018

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Cryptic proteolytic activity of dihydrolipoamide dehydrogenase

5 July 2018

1 reference

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Disulphide formation on mitochondrial protein thiols.

5 July 2018

1 reference

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Thiol-disulfide balance: from the concept of oxidative stress to that of redox regulation.

5 July 2018

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Glutaredoxin: role in reversible protein s-glutathionylation and regulation of redox signal transduction and protein translocation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Lipoyl synthase requires two equivalents of S-adenosyl-L-methionine to synthesize one equivalent of lipoic acid.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Assembly of the covalent linkage between lipoic acid and its cognate enzymes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Redox-dependent modulation of aconitase activity in intact mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

2-Oxo acid dehydrogenase complexes in redox regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Free radicals in the physiological control of cell function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Mitochondrial free radical generation, oxidative stress, and aging

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Redox signaling: hydrogen peroxide as intracellular messenger

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Interaction of thioredoxins with target proteins: role of particular structural elements and electrostatic properties of thioredoxins in their interplay with 2-oxoacid dehydrogenase complexes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Activation of mitochondrial 2-oxoacid dehydrogenases by thioredoxin.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Brain energy metabolizing enzymes in Alzheimer's disease: alpha-ketoglutarate dehydrogenase complex and cytochrome oxidase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Why do mitochondria synthesize fatty acids? Evidence for involvement in lipoic acid production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Aging, energy, and oxidative stress in neurodegenerative diseases.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Thiol/disulfide exchange equilibria and disulfide bond stability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

The role of oxygen free radicals in preconditioning

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Tricarboxylic acid cycle flux and enzyme activities in the isolated working rat heart

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Amino acid sequence homology between pig heart lipoamide dehydrogenase and human erythrocyte glutathione reductase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Complex I binds several mitochondrial NAD-coupled dehydrogenases.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Dihydrolipoamide dehydrogenase: functional similarities and divergent evolution of the pyridine nucleotide-disulfide oxidoreductases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Localization of the alpha-oxoacid dehydrogenase multienzyme complexes within the mitochondrion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Lipoamidase is a multiple hydrolase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Domains, motifs, and linkers in 2-oxo acid dehydrogenase multienzyme complexes: a paradigm in the design of a multifunctional protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Ischemic preconditioning inhibits mitochondrial respiration, increases H2O2 release, and enhances K+ transport

5 July 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2010.534163

Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2010.534163

Ischemic preconditioning: triggering role of nitric oxide-derived oxidants in isolated hearts.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2010.534163

Protective effects of hydrogen peroxide against ischemia/reperfusion injury in perfused rat hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2010.534163

Modulation of mitochondrial function by hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2010.534163

Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2010.534163

Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2010.534163

Inhibition of α‐ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase‐3 activation, and necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2010.534163

Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2010.534163

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2010.534163

Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2010.534163

Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169906

Elementary steps in the reaction mechanism of the alpha-ketoglutarate dehydrogenase multienzyme complex from Escherichia coli: kinetics of succinylation and desuccinylation

29 October 2018

1 reference

12 December 2020

Inactivation of 2-oxoglutarate dehydrogenase in rat liver mitochondria by its substrate and t-butyl hydroperoxide

1 reference

12 December 2020

Interaction between NAD-dependent isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase complex, and NADH:ubiquinone oxidoreductase

1 reference

12 December 2020

Substrate channeling of NADH and binding of dehydrogenases to complex I

1 reference

12 December 2020

Thioredoxin reduction dependent on alpha-ketoacid oxidation by alpha-ketoacid dehydrogenase complexes

1 reference

12 December 2020

Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal

1 reference

12 December 2020

Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal

1 reference

12 December 2020

1 reference

12 December 2020

The respiratory chain and oxidative phosphorylation

1 reference

12 December 2020

Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium

1 reference

12 December 2020

Oxygen radicals can induce preconditioning in rabbit hearts

1 reference

12 December 2020

Preconditioning prevents loss in mitochondrial function and release of cytochrome c during prolonged cardiac ischemia/reperfusion

1 reference

12 December 2020

10.3109/10715762.2010.534163

Identifiers

DOI

1 reference

30 July 2017

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30 July 2017

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