(Q34025605)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21290398%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21290398%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

0 references

1 reference

2

1 reference

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21 January 2020

1

John R Speakman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21290398%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

language of work or name

English

0 references

publication date

2 February 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21290398%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21290398%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

volume

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21290398%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21290398%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

page(s)

255-259

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21290398%20AND%20SRC:MED&resulttype=core&format=json

High anoxia tolerance in the subterranean salamander Proteus anguinus without oxidative stress nor activation of antioxidant defenses during reoxygenation

21 January 2020

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21 January 2018

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Extreme lifespan of the human fish (Proteus anguinus): a challenge for ageing mechanisms

21 January 2018

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Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria.

21 January 2018

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Does oxidative damage to DNA increase with age?

21 January 2018

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Oxidative stress, caloric restriction, and aging

21 January 2018

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Comparative biology of aging in birds: an update

21 January 2018

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Energetics and longevity in birds

21 January 2018

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Ageing studies on bats: a review

21 January 2018

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Mammalian aging, metabolism, and ecology: evidence from the bats and marsupials

21 January 2018

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Body size, energy metabolism and lifespan

21 January 2018

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Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon

21 January 2018

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Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate

21 January 2018

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Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms

21 January 2018

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Protein oxidative damage is associated with life expectancy of houseflies

21 January 2018

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Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

21 January 2018

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DNA oxidative damage and life expectancy in houseflies

21 January 2018

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21 January 2018

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Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels

21 January 2018

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Minireview: the role of oxidative stress in relation to caloric restriction and longevity.

21 January 2018

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Oxidative stress and mitochondrial function with aging--the effects of calorie restriction

21 January 2018

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Oxidative stress shortens telomeres

21 January 2018

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Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

21 January 2018

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Birds sacrifice oxidative protection for reproduction.

21 January 2018

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Trade-Offs in Life-History Evolution

21 January 2018

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Life history evolution: successes, limitations, and prospects

21 January 2018

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Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation.

21 January 2018

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The physiological costs of reproduction in small mammals

21 January 2018

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Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?

21 January 2018

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Trends in oxidative aging theories

21 January 2018

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Is the oxidative stress theory of aging dead?

21 January 2018

1 reference

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Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: implications for aging studies.

21 January 2018

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Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

21 January 2018

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Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

21 January 2018

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The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice

21 January 2018

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Vitamin E supplementation and mammalian lifespan

21 January 2018

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Lifelong alpha-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage

21 January 2018

1 reference

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Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes.

21 January 2018

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Antioxidants: benefits and risks for long-term health

21 January 2018

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The effect of long-term dietary supplementation with antioxidants.

21 January 2018

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Antioxidants prevent health-promoting effects of physical exercise in humans

21 January 2018

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How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

21 January 2018

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Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

21 January 2018

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Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

21 January 2018

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Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span

21 January 2018

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Extension of murine life span by overexpression of catalase targeted to mitochondria

21 January 2018

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The overexpression of major antioxidant enzymes does not extend the lifespan of mice

21 January 2018

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Overexpression of Mn superoxide dismutase does not increase life span in mice

21 January 2018

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Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity

21 January 2018

1 reference

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Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

21 January 2018

1 reference

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A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans

21 January 2018

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Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

21 January 2018

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The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole Microtus agrestis.

21 January 2018

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Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat

21 January 2018

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The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms

21 January 2018

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Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?

21 January 2018

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