(Q34030512)

30 July 2017

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title

Potential applications of gene therapy in the patient with cancer (English)

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30 July 2017

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Szlosarek PW

1

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30 July 2017

Dalgleish AG

series ordinal

2

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30 July 2017

publication date

1 August 2000

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30 July 2017

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30 July 2017

volume

17

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30 July 2017

issue

2

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30 July 2017

page(s)

121-132

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Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.

30 July 2017

cites work

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12 December 2020

AAVant-garde gene therapy

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12 December 2020

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

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12 December 2020

Gene therapy strategies for tumor antiangiogenesis

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12 December 2020

In vivo studies with antisense oligonucleotides

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12 December 2020

Escape of mouse mastocytoma P815 after nearly complete rejection is due to antigen-loss variants rather than immunosuppression

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12 December 2020

Gene therapy--a loss of innocence

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12 December 2020

Generation of CD8+ and CD4+ T-cell response to dendritic cells genetically engineered to express the MART-1/Melan-A gene

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12 December 2020

Clinical application of retroviral gene transfer in oncology: results of a French study with tumor-infiltrating lymphocytes transduced with the gene of resistance to neomycin.

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12 December 2020

Interleukin 7 induces CD4+ T cell-dependent tumor rejection

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12 December 2020

Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting protein kinase A in combination with docetaxel and anti-epidermal growth factor-receptor antibody on human breast cancer cell growth

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12 December 2020

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

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12 December 2020

p53 mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy

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12 December 2020

The development of therapeutic vaccines of the management of malignant melanoma.

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12 December 2020

Gene therapy for cancer: what have we done and where are we going?

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12 December 2020

Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function

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12 December 2020

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

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12 December 2020

Can immunotherapy by gene transfer tip the balance against colorectal cancer?

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12 December 2020

Bone marrow-derived dendritic cells pulsed with a tumor-specific peptide elicit effective anti-tumor immunity against intracranial neoplasms

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12 December 2020

The case for therapeutic vaccines.

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12 December 2020

Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells.

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12 December 2020

A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon alpha

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12 December 2020

HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia

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12 December 2020

Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene

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12 December 2020

Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro

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12 December 2020

Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma

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12 December 2020

An overview of gene therapy approaches to neurological malignancies

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12 December 2020

Reversal of the metastatic phenotype in Lewis lung carcinoma cells after transfection with syngeneic H-2Kb gene

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12 December 2020

Second-generation adenovirus vectors

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12 December 2020

Reovirus therapy of tumors with activated Ras pathway

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12 December 2020

Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors

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12 December 2020

Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells

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12 December 2020

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors

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12 December 2020

Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction

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12 December 2020

Specific cytotoxic T lymphocytes in gene therapy

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12 December 2020

Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer

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12 December 2020

Chemoprotection of normal tissues by transfer of drug resistance genes

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12 December 2020

Loss of adenoviral receptor expression in human bladder cancer cells: a potential impact on the efficacy of gene therapy.

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12 December 2020

Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA-liposome complexes

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12 December 2020

Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression

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12 December 2020

Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial

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12 December 2020

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

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12 December 2020

Good manufacturing practice production of human stem cells for somatic cell and gene therapy

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12 December 2020

Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1

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12 December 2020

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

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12 December 2020

Emerging concepts in GM-CSF gene-transduced tumor vaccines for human prostate cancer

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12 December 2020

Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML.

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12 December 2020

DNA-based immunization by in vivo transfection of dendritic cells

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12 December 2020

Human gene marker/therapy clinical protocols

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12 December 2020

T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years.

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12 December 2020

Generation of an adenovirus vector lacking E1, e2a, E3, and all of E4 except open reading frame 3.

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12 December 2020

Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors

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12 December 2020

Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter

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12 December 2020

Gene therapy for prostate cancer

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12 December 2020

Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection.

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12 December 2020

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity

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12 December 2020

A Phase I clinical trial of immunotherapy with interferon-gamma gene-modified autologous melanoma cells: monitoring the humoral immune response

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12 December 2020

Molecular chemotherapy for breast cancer

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12 December 2020

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells

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12 December 2020

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene

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12 December 2020

Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma

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12 December 2020

Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect

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12 December 2020

Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

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12 December 2020

Antiangiogenesis treatment for gliomas: transfer of antisense-vascular endothelial growth factor inhibits tumor growth in vivo

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12 December 2020

Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery

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12 December 2020

A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy

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12 December 2020

A phase I/II dose-escalation study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for metastatic melanoma. Study Group on Gene Therapy of Metastatic Melanoma

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12 December 2020

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

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12 December 2020

How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.

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12 December 2020

Vectors in cancer therapy: how will they deliver?

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12 December 2020

Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm.

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12 December 2020

Mechanism of activation of early viral transcription by the adenovirus E1A gene product

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12 December 2020

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system

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12 December 2020

Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype

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12 December 2020

Identification of disease genes and somatic gene therapy: an overview and prospects for the aged

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12 December 2020

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

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12 December 2020

Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

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12 December 2020

Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy

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12 December 2020

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

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12 December 2020

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

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12 December 2020

Increased bax expression is associated with cell death induced by ganciclovir in a herpes thymidine kinase gene-expressing glioma cell line

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12 December 2020

Drug delivery and targeting

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12 December 2020

Retroviral transduction of human dendritic cells with a tumor-associated antigen gene.

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12 December 2020

Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth

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12 December 2020

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene

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12 December 2020

Immunoselection in vivo: independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma

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12 December 2020

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.

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12 December 2020

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate

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12 December 2020

Transfer of the HSV-tk gene into donor peripheral blood lymphocytes for in vivo modulation of donor anti-tumor immunity after allogeneic bone marrow transplantation

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12 December 2020

Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice.

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12 December 2020

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

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12 December 2020

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12 December 2020

Expression of Fas ligand in liver metastases of human colonic adenocarcinomas

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12 December 2020

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors

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12 December 2020

Use of recombinant poxviruses to stimulate anti-melanoma T cell reactivity

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12 December 2020

Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity

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12 December 2020

Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA.

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12 December 2020

In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes

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12 December 2020

Development of optimized vectors for gene therapy

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12 December 2020

Dendritic cells and the control of immunity

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12 December 2020

Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression

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12 December 2020

Immunotherapy of metastatic malignant melanoma by a vaccine consisting of autologous interleukin 2-transfected cancer cells: outcome of a phase I study

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12 December 2020

A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody/Fc-gamma chain chimeric receptor gene recognizing a human ovarian cancer antigen

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12 December 2020

Cytokine and chemokine: a stimulating couple

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12 December 2020

Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3.

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12 December 2020

Anti-tumor activity of human T cells expressing the CC49-zeta chimeric immune receptor

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12 December 2020

Antiangiogenic gene therapy in a rat glioma model using a dominant-negative vascular endothelial growth factor receptor 2.

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12 December 2020

DNA immunization induces protective immunity against B-cell lymphoma

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12 December 2020

Gene-marking to trace origin of relapse after autologous bone-marrow transplantation.

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12 December 2020

p53-dependent cell death/apoptosis is required for a productive adenovirus infection

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12 December 2020

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

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12 December 2020

ONYX-015: clinical data are encouraging

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12 December 2020

Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter

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12 December 2020

Systemic gene delivery expands the repertoire of effective antiangiogenic agents

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12 December 2020

Expression of the primary coxsackie and adenovirus receptor is downregulated during skeletal muscle maturation and limits the efficacy of adenovirus-mediated gene delivery to muscle cells

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12 December 2020

Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral

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12 December 2020

Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells

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12 December 2020

Immunotherapy of cancer with dendritic-cell-based vaccines

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12 December 2020

Ability of oligonucleotides with certain palindromes to induce interferon production and augment natural killer cell activity is associated with their base length

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12 December 2020

Cancer gene therapy: connecting basic research with clinical inquiry

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12 December 2020

Immunoselection of a human melanoma resistant to specific lysis by autologous tumor-infiltrating lymphocytes. Possible mechanisms for immunotherapeutic failures

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12 December 2020

Combined chemokine and cytokine gene transfer enhances antitumor immunity

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12 December 2020

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

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12 December 2020

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

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12 December 2020

Transfer and expression of the human multiple drug resistance gene into live mice

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12 December 2020

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity

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12 December 2020

The role of herpes simplex virus thymidine kinase in the treatment of solid tumours

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12 December 2020

Effective and safe gene therapy for colorectal carcinoma using the cytosine deaminase gene directed by the carcinoembryonic antigen promoter

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12 December 2020

Immunotherapy with T cells bearing chimeric antitumor receptors

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12 December 2020

Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases

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12 December 2020

Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation.

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12 December 2020

Antisense oligonucleotides as therapeutics for malignant diseases.

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12 December 2020

Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells

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12 December 2020

TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis

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12 December 2020

10.2165/00002512-200017020-00004

Identifiers

DOI

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Dimensions Publication ID

30 July 2017

1045193676

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