(Q34034756)

30 July 2017

title

Production of unique immunotoxin cancer therapeutics in algal chloroplasts (English)

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30 July 2017

7

Stephen P Mayfield

1 reference

30 July 2017

Miller Tran

1

1 reference

30 July 2017

Christina Van

2

1 reference

30 July 2017

Daniel J Barrera

3

1 reference

30 July 2017

Pär L Pettersson

4

1 reference

30 July 2017

Carlos D Peinado

5

1 reference

30 July 2017

Jack Bui

6

1 reference

30 July 2017

language of work or name

English

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publication date

10 December 2012

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

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30 July 2017

volume

110

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30 July 2017

issue

1

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30 July 2017

page(s)

E15-22

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Robust expression and secretion of Xylanase1 in Chlamydomonas reinhardtii by fusion to a selection gene and processing with the FMDV 2A peptide

30 July 2017

cites work

1 reference

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Exploiting diversity and synthetic biology for the production of algal biofuels

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Algae-produced Pfs25 elicits antibodies that inhibit malaria transmission

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Brentuximab vedotin: a new age in the treatment of Hodgkin lymphoma and anaplastic large cell lymphoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Biofuels from algae: challenges and potential

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

The microalga Chlamydomonas reinhardtii as a platform for the production of human protein therapeutics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

The next generation of antibody-drug conjugates comes of age.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Micro-algae come of age as a platform for recombinant protein production

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Recombinant, ETA'-based CD64 immunotoxins: improved efficacy by increased valency, both in vitro and in vivo in a chronic cutaneous inflammation model in human CD64 transgenic mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Production of therapeutic proteins in algae, analysis of expression of seven human proteins in the chloroplast of Chlamydomonas reinhardtii

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

CAIcal: a combined set of tools to assess codon usage adaptation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Structure of the chloroplast ribosome: novel domains for translation regulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Chlamydomonas reinhardtii chloroplasts as protein factories.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Immunotoxin treatment of cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Select what you need: a comparative evaluation of the advantages and limitations of frequently used expression systems for foreign genes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Pathways for protein disulphide bond formation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Protein disulfide isomerase as a regulator of chloroplast translational activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Recombinant RFB4 single-chain immunotoxin that is cytotoxic towards CD22-positive cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

A recombinant immunotoxin containing a disulfide-stabilized Fv fragment

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Evaluation of four CD22 antibodies as ricin A chain-containing immunotoxins for the in vivo therapy of human B-cell leukemias and lymphomas

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Plant organelles contain distinct peptidylprolyl cis,trans-isomerases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Prospects for molecular farming in the green alga Chlamydomonas

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

Single-chain antibody-based immunotoxins targeting Her2/neu: design optimization and impact of affinity on antitumor efficacy and off-target toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

Chloroplast elongation factor ts pro-protein is an evolutionarily conserved fusion with the s1 domain-containing plastid-specific ribosomal protein-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

The Chlamydomonas genome reveals its secrets: chaperone genes and the potential roles of their gene products in the chloroplast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

Robust expression of a bioactive mammalian protein in Chlamydomonas chloroplast

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

Development of a luciferase reporter gene, luxCt, for Chlamydomonas reinhardtii chloroplast

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

Chaperone over-expression in Escherichia coli: apparent increased yields of soluble recombinant protein kinases are due mainly to soluble aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

Intrachain disulfide bond in the core hinge region of human IgG4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

Plastid transformation in higher plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

Antibody-drug conjugates: targeted drug delivery for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1214638110

Synthesis and assembly of a full-length human monoclonal antibody in algal chloroplasts

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Bivalent disulfide-stabilized fragment variable immunotoxin directed against mesotheliomas and ovarian cancer

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538218

[Antibody-drug conjugate--a new age for personalized cancer treatment]

29 October 2018

1 reference

12 December 2020

Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain

1 reference

12 December 2020

Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys

1 reference

12 December 2020

Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression

1 reference

12 December 2020

Light-regulated translation of chloroplast messenger RNAs through redox potential

1 reference

12 December 2020

Characterization of RFB4-Pseudomonas exotoxin A immunotoxins targeted to CD22 on B-cell malignancies

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1214638110

1 reference

30 July 2017

0 references

1 reference

30 July 2017

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