(Q34036957)

30 July 2017

Deficits in human trisomy 21 iPSCs and neurons (English)

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30 July 2017

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Jason P Weick

1

1 reference

30 July 2017

Dustie L Held

2

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30 July 2017

George F Bonadurer

3

1 reference

30 July 2017

Matthew E Doers

4

1 reference

30 July 2017

Yan Liu

5

1 reference

30 July 2017

Chelsie Maguire

6

1 reference

30 July 2017

Aaron Clark

7

1 reference

30 July 2017

Joshua A Knackert

8

1 reference

30 July 2017

Katharine Molinarolo

9

1 reference

30 July 2017

Michael Musser

10

1 reference

30 July 2017

Lin Yao

11

1 reference

30 July 2017

Yingnan Yin

12

1 reference

30 July 2017

Jianfeng Lu

13

1 reference

30 July 2017

Xiaoqing Zhang

14

1 reference

30 July 2017

Su-Chun Zhang

15

1 reference

30 July 2017

Anita Bhattacharyya

16

1 reference

30 July 2017

language of work or name

English

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publication date

28 May 2013

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

1 reference

30 July 2017

110

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30 July 2017

24

1 reference

30 July 2017

9962-9967

1 reference

describes a project that uses

30 July 2017

0 references

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Adaptive downregulation of mitochondrial function in down syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Oxidative Stress and Mitochondrial Dysfunction in Down's Syndrome: Relevance to Aging and Dementia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Genomic determinants in the phenotypic variability of Down syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

A human stem cell model of early Alzheimer's disease pathology in Down syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Gli proteins in development and disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

A call for standardized naming and reporting of human ESC and iPSC lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

A functionally characterized test set of human induced pluripotent stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Down syndrome: from understanding the neurobiology to therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Human embryonic stem cells as models for aneuploid chromosomal syndromes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Pax6 is a human neuroectoderm cell fate determinant

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Induced pluripotent stem cell lines derived from human somatic cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Alzheimer's disease in Down syndrome: neurobiology and risk.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Alzheimer disease, the two-hit hypothesis: an update

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Neural subtype specification from embryonic stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Oxidative stress: a bridge between Down's syndrome and Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Human neural stem cells: a new tool for studying cortical development in Down's syndrome.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Chromosome 21: from sequence to applications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

The sequence of human chromosome 21 and implications for research into Down syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Too much of a good thing: mechanisms of gene action in Down syndrome.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Development of the superior temporal neocortex is anomalous in trisomy 21.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative Golgi study.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

The consequences of chromosome imbalance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Mosaic Down's syndrome prevalence in a complete population study

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

Down's syndrome: Is there a decreased population of neurons?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

Reduced cell number in the neocortical part of the human fetal brain in Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

Integration-free induced pluripotent stem cells model genetic and neural developmental features of down syndrome etiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

In vitro differentiation of transplantable neural precursors from human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216575110

H(2)O(2) is a novel, endogenous modulator of synaptic dopamine release

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Hydrogen peroxide inhibits the vacuolar H+-ATPase in brain synaptic vesicles at micromolar concentrations.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Evidence of arrest of neurogenesis and synaptogenesis in brains of patients with Down's syndrome.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683748

Over-inhibition: a model for developmental intellectual disability

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23716668

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1216575110

1 reference

release_mowhtvhbeneo7lhoz6nblxo7h4

30 July 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mowhtvhbeneo7lhoz6nblxo7h4

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

3683748

1 reference

30 July 2017

1 reference