(Q34039363)

30 July 2017

The role of iron and reactive oxygen species in cell death (English)

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30 July 2017

reactive oxygen species

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Scott J Dixon

1

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PubMed ID

24346035

30 July 2017

Brent R Stockwell

series ordinal

2

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30 July 2017

1 January 2014

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30 July 2017

Nature Chemical Biology

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30 July 2017

10

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30 July 2017

1

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30 July 2017

9-17

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https://scigraph.springernature.com/pub.10.1038/nchembio.1416

30 July 2017

0 references

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12 December 2020

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

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12 December 2020

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12 December 2020

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress

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12 December 2020

Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death

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12 December 2020

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

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12 December 2020

Sphingolipid signaling mediates iron toxicity

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Translocation of iron from lysosomes to mitochondria during ischemia predisposes to injury after reperfusion in rat hepatocytes

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12 December 2020

A yeast mutant showing diagnostic markers of early and late apoptosis

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12 December 2020

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

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12 December 2020

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

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12 December 2020

Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix

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12 December 2020

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

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12 December 2020

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

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12 December 2020

Loss of iron triggers PINK1/Parkin-independent mitophagy

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12 December 2020

Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.

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12 December 2020

Mitochondrial disease in superoxide dismutase 2 mutant mice

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12 December 2020

Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells.

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12 December 2020

Modulatory profiling identifies mechanisms of small molecule-induced cell death.

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12 December 2020

In vivo mapping of hydrogen peroxide and oxidized glutathione reveals chemical and regional specificity of redox homeostasis.

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12 December 2020

Microbial metalloproteomes are largely uncharacterized.

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12 December 2020

Molecular imaging of labile iron(II) pools in living cells with a turn-on fluorescent probe.

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12 December 2020

The developing oligodendrocyte: key cellular target in brain injury in the premature infant

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12 December 2020

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12 December 2020

Iron and cancer: more ore to be mined

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12 December 2020

A common mechanism of cellular death induced by bactericidal antibiotics

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12 December 2020

Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast

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12 December 2020

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

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12 December 2020

Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels

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12 December 2020

The environment of the lipoxygenase iron binding site explored with novel hydroxypyridinone iron chelators

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12 December 2020

Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates

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12 December 2020

Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, [...]

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12 December 2020

Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways

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12 December 2020

TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death

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12 December 2020

CCC1 is a transporter that mediates vacuolar iron storage in yeast

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12 December 2020

Oxytosis: A novel form of programmed cell death

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12 December 2020

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

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12 December 2020

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease.

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12 December 2020

A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

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12 December 2020

Orm family proteins mediate sphingolipid homeostasis

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12 December 2020

Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

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12 December 2020

Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

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12 December 2020

Cell death from antibiotics without the involvement of reactive oxygen species

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12 December 2020

Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited

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12 December 2020

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

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12 December 2020

Micromolar intracellular hydrogen peroxide disrupts metabolism by damaging iron-sulfur enzymes

1 reference

12 December 2020

Hydrogen peroxide inactivates the Escherichia coli Isc iron-sulphur assembly system, and OxyR induces the Suf system to compensate

1 reference

12 December 2020

Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in Escherichia coli

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12 December 2020

Iron content of Saccharomyces cerevisiae cells grown under iron-deficient and iron-overload conditions

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12 December 2020

Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness

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12 December 2020

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

1 reference

12 December 2020

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

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12 December 2020

Genetic and biochemical analysis of high iron toxicity in yeast: iron toxicity is due to the accumulation of cytosolic iron and occurs under both aerobic and anaerobic conditions

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12 December 2020

Molecular bases of cellular iron toxicity

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12 December 2020

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

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12 December 2020

Two to tango: regulation of Mammalian iron metabolism

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12 December 2020

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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12 December 2020

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

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12 December 2020

Mitochondrial disease in mouse results in increased oxidative stress

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12 December 2020

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

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12 December 2020

GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis

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12 December 2020

Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury

1 reference

12 December 2020

Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture

1 reference

12 December 2020

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

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12 December 2020

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

1 reference

12 December 2020

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

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12 December 2020

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

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12 December 2020

The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium

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12 December 2020

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

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12 December 2020

Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug

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12 December 2020

The neuropathology of neurodegeneration with brain iron accumulation

1 reference

12 December 2020

Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain.

1 reference

12 December 2020

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

1 reference

12 December 2020

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

1 reference

12 December 2020

Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity

1 reference

12 December 2020

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1 reference

12 December 2020

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

1 reference

12 December 2020

The chelatable iron pool in living cells: a methodically defined quantity

1 reference

12 December 2020

Bid-induced mitochondrial membrane permeabilization waves propagated by local reactive oxygen species (ROS) signaling

1 reference

12 December 2020

NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1.

1 reference

12 December 2020

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1 reference

12 December 2020

Iron enzyme ribulose-5-phosphate 3-epimerase in Escherichia coli is rapidly damaged by hydrogen peroxide but can be protected by manganese

1 reference

12 December 2020

Isolation of superoxide dismutase mutants in Escherichia coli: is superoxide dismutase necessary for aerobic life?

1 reference

12 December 2020

Association of reactive oxygen species levels and radioresistance in cancer stem cells

1 reference

12 December 2020

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

1 reference

12 December 2020

Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production

1 reference

12 December 2020

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.

1 reference

12 December 2020

p53 opens the mitochondrial permeability transition pore to trigger necrosis

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12 December 2020

Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli

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12 December 2020

Mononuclear iron enzymes are primary targets of hydrogen peroxide stress

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12 December 2020

The inactivation of Fe-S cluster containing hydro-lyases by superoxide.

1 reference

12 December 2020

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

1 reference

12 December 2020

Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells

1 reference

12 December 2020

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties

1 reference

12 December 2020

Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis

1 reference

12 December 2020

Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex

1 reference

12 December 2020

TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation.

1 reference

12 December 2020

Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease

1 reference

12 December 2020

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway.

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1416

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO.1416

1 reference

30 July 2017

1 reference

PubMed ID

24346035