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PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?
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Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
review article
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Europe PubMed Central
title
PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?
(English)
1 reference
stated in
Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
main subject
DNA damage
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author
Vanesa Gottifredi
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
author name string
Gastón Soria
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
publication date
8 January 2010
1 reference
stated in
Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
published in
DNA Repair
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stated in
Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
volume
9
1 reference
stated in
Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
page(s)
358-364
1 reference
stated in
Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
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Degradation of p21CDKN1A after DNA damage is independent of type of lesion, and is not required for DNA repair.
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Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase
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The p21 and PCNA partnership: a new twist for an old plot
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Human DNA polymerase iota protects cells against oxidative stress
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The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing
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PubMed Central
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5 July 2018
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
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PubMed Central
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p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation.
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CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation
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APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase
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DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase
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PCNA, the maestro of the replication fork
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Translesion synthesis: Y-family polymerases and the polymerase switch
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p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled.
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DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1
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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
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UV Induces p21 rapid turnover independently of ubiquitin and Skp2.
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CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome
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5 July 2018
PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination
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Proliferating cell nuclear antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching
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Trading places: how do DNA polymerases switch during translesion DNA synthesis?
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UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.
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The S phase checkpoint: when the crowd meets at the fork
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5 July 2018
Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block
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reference URL
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5 July 2018
Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.
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5 July 2018
UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair
1 reference
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PubMed Central
reference URL
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5 July 2018
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915755
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5 July 2018
Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation
1 reference
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PubMed Central
reference URL
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5 July 2018
A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome
1 reference
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PubMed Central
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5 July 2018
p53 accumulates but is functionally impaired when DNA synthesis is blocked
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915755
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5 July 2018
p21(WAF1/Cip1): more than a break to the cell cycle?
1 reference
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PubMed Central
reference URL
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5 July 2018
Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915755
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5 July 2018
Activity and nature of p21(WAF1) complexes during the cell cycle
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5 July 2018
WAF1, a potential mediator of p53 tumor suppression
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5 July 2018
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915755
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5 July 2018
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint
1 reference
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28 October 2018
Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915755
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28 October 2018
Glycogen synthase kinase 3beta phosphorylates p21WAF1/CIP1 for proteasomal degradation after UV irradiation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915755
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28 October 2018
P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915755
retrieved
28 October 2018
The fate of p21CDKN1A in cells surviving UV-irradiation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2915755
retrieved
28 October 2018
PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20060369
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.DNAREP.2009.12.003
1 reference
stated in
Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
PMCID
2915755
1 reference
stated in
Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
PubMed ID
20060369
1 reference
stated in
Europe PubMed Central
PMCID
2915755
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20060369%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
ResearchGate publication ID
40898118
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