(Q34054400)

30 July 2017

title

Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold (English)

1 reference

30 July 2017

Guijia He

1

1 reference

30 July 2017

Dengfeng Dou

2

1 reference

30 July 2017

Liuqing Wei

3

1 reference

30 July 2017

Kevin R Alliston

4

1 reference

30 July 2017

William C Groutas

5

1 reference

30 July 2017

publication date

30 June 2010

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European Journal of Medicinal Chemistry

30 July 2017

published in

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30 July 2017

volume

45

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30 July 2017

issue

9

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30 July 2017

page(s)

4280-4287

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Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery

30 July 2017

cites work

1 reference

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Testing drugs in animal models of cigarette smoke-induced chronic obstructive pulmonary disease

5 July 2018

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Burden and pathogenesis of chronic obstructive pulmonary disease

5 July 2018

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New drugs for exacerbations of chronic obstructive pulmonary disease

5 July 2018

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Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding.

5 July 2018

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5 July 2018

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Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

5 July 2018

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Epithelial cell apoptosis causes acute lung injury masquerading as emphysema

5 July 2018

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X-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives †

5 July 2018

1 reference

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Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions

5 July 2018

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Neutrophil serine proteases: specific regulators of inflammation

5 July 2018

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Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema

5 July 2018

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Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease

5 July 2018

1 reference

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The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100 years

5 July 2018

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Neutrophil serine proteases: potential key regulators of cell signalling during inflammation

5 July 2018

1 reference

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Mediators of chronic obstructive pulmonary disease

5 July 2018

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Noncovalent inhibitors of human leukocyte elastase based on the 4-imidazolidinone scaffold

5 July 2018

1 reference

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The determination of enzyme inhibitor constants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

Alveolar wall apoptosis causes lung destruction and emphysematous changes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

Irreversible inhibitors of serine, cysteine, and threonine proteases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures(1).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies

5 July 2018

1 reference

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On the size of the active site in proteases. I. Papain

5 July 2018

1 reference

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Inspection of the binding sites of proteinase3 for the design of a highly specific substrate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

Design and use of highly specific substrates of neutrophil elastase and proteinase 3.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

Apoptosis and emphysema: the missing link.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918731

Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

28 October 2018

1 reference

12 December 2020

Inhibitors of human leukocyte proteinase-3

1 reference

12 December 2020

Design of selective substrates of proteinase 3 using combinatorial chemistry methods

1 reference

12 December 2020

Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3

1 reference

12 December 2020

Epithelial responses to oxidative stress in chronic obstructive pulmonary disease: lessons from expression profiling

1 reference

12 December 2020

Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide

1 reference

12 December 2020

Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates

1 reference

12 December 2020

10.1016/J.EJMECH.2010.06.028

Identifiers

DOI

1 reference

30 July 2017

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30 July 2017

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