(Q34055922)

English

A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway

scientific article

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway (English)

1 reference

Europe PubMed Central

30 July 2017

1 reference

based on heuristic

inferred from title

allosteric inhibitor

1 reference

based on heuristic

inferred from title

Christian Le Gouill

7

object named as

Christian Le Gouill

0 references

William D. Lubell

object named as

William D Lubell

13

0 references

object named as

Michel Bouvier

10

0 references

Sylvain Chemtob

12

object named as

Sylvain Chemtob

1 reference

Europe PubMed Central

30 July 2017

Christiane Quiniou

4

object named as

Christiane Quiniou

1 reference

Europe PubMed Central

30 July 2017

author name string

Eugénie Goupil

1

1 reference

Europe PubMed Central

30 July 2017

Danaë Tassy

2

1 reference

Europe PubMed Central

30 July 2017

Carine Bourguet

3

1 reference

Europe PubMed Central

30 July 2017

Veronica Wisehart

5

1 reference

Europe PubMed Central

30 July 2017

Darlaine Pétrin

6

1 reference

Europe PubMed Central

30 July 2017

Christian Le Gouill

7

1 reference

Europe PubMed Central

30 July 2017

Dominic Devost

8

1 reference

Europe PubMed Central

30 July 2017

Hans H Zingg

9

1 reference

Europe PubMed Central

30 July 2017

Horacio Uri Saragovi

11

1 reference

Europe PubMed Central

30 July 2017

Audrey Claing

14

1 reference

Europe PubMed Central

30 July 2017

Terence E Hébert

15

1 reference

Europe PubMed Central

30 July 2017

Stéphane A Laporte

16

1 reference

Europe PubMed Central

30 July 2017

language of work or name

0 references

publication date

15 June 2010

1 reference

Europe PubMed Central

30 July 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

30 July 2017

285

1 reference

Europe PubMed Central

30 July 2017

33

1 reference

Europe PubMed Central

30 July 2017

25624-25636

1 reference

Europe PubMed Central

30 July 2017

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

1 reference

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28 July 2018

Functional selectivity through protean and biased agonism: who steers the ship?

1 reference

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28 July 2018

The evasive nature of drug efficacy: implications for drug discovery

1 reference

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28 July 2018

Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.

1 reference

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28 July 2018

An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Prostaglandin F2alpha and its receptor as activators of human decidua

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Novel in vitro system for functional assessment of oxytocin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1alpha

1 reference

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28 July 2018

Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Rho GTPases: biochemistry and biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Localized RhoA activation as a requirement for the induction of membrane ruffling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Design, synthesis, and application of azabicyclo[X.Y.0]alkanone amino acids as constrained dipeptide surrogates and peptide mimics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Essential role for the second extracellular loop in C5a receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

G-protein-coupled receptor allosterism: the promise and the problem(s).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

The role of prostaglandins in the initiation of parturition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Myometrial activation and preterm labour: evidence supporting a role for the prostaglandin F receptor--a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

THG113: a novel selective FP antagonist that delays preterm labor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

G protein-coupled receptor allosterism and complexing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Oxytocin antagonists: clinical and scientific considerations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Induction of c-fos and c-jun messenger ribonucleic acid expression by prostaglandin F2alpha is mediated by a protein kinase C-dependent extracellular signal-regulated kinase mitogen-activated protein kinase pathway in bovine luteal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Activation of FP prostanoid receptor isoforms leads to Rho-mediated changes in cell morphology and in the cell cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Failure of parturition in mice lacking the prostaglandin F receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Rho as a regulator of the cytoskeleton.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

The contribution of low birth weight to infant mortality and childhood morbidity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Prostaglandin F2 alpha stimulates phosphatidylinositol 4,5-bisphosphate hydrolysis and mobilizes intracellular Ca2+ in bovine luteal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 July 2018

Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

RHO protein regulation of contraction in the human uterus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Exploring the relationship between turn geometry and allosteric antagonism of peptide mimic ligands for the prostaglandin F2alpha receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Analysis of the spatiotemporal activation of rho GTPases using Raichu probes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Tocolytic effect of a Rho-kinase inhibitor in a mouse model of lipopolysaccharide-induced preterm delivery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Risk-benefit effects of tocolytic therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Allergic sensitization enhances the contribution of Rho-kinase to airway smooth muscle contraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Investigation of the Interaction of a Putative Allosteric Modulator,N-(2,3-Diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) Methanamine Hydrobromide (SCH-202676), with M1Muscarinic Acetylcholine Receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Models and methods for studying insurmountable antagonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Determinants of preterm birth rates in Canada from 1981 through 1983 and from 1992 through 1994.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Prostaglandin F2 alpha (PGF2 alpha) triggers protein kinase C (PKC) and tyrosine kinase activity in cultured mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Allosteric regulation of muscarinic receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

28 October 2018

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919126

10 December 2018

Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20551320

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin F2 alpha receptor is coupled to Gq in cDNA-transfected Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20551320

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of mitogen-activated protein kinase pathway in prostaglandin F2alpha-induced rat puerperal uterine contraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20551320

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular mechanisms underlying prostaglandin F2alpha-stimulated phasic myometrial contractions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20551320

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20551320

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Female reproduction in mice lacking the prostaglandin F receptor. Roles of prostaglandin and oxytocin receptors in parturition

1 reference

https://pubmed.ncbi.nlm.nih.gov/20551320

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.115196

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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