(Q34055936)

30 July 2017

title

Functional kinomics identifies candidate therapeutic targets in head and neck cancer (English)

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30 July 2017

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head and neck carcinoma

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11

Adam A Margolin

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30 July 2017

10

Wendell G Yarbrough

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30 July 2017

Russell Moser

1

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30 July 2017

Chang Xu

2

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30 July 2017

Michael Kao

3

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30 July 2017

James Annis

4

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30 July 2017

Luisa Angelica Lerma

5

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30 July 2017

Christopher M Schaupp

6

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30 July 2017

Kay E Gurley

7

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30 July 2017

In Sock Jang

8

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30 July 2017

Asel Biktasova

9

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30 July 2017

Carla Grandori

12

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30 July 2017

Christopher J Kemp

13

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30 July 2017

Eduardo Méndez

14

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30 July 2017

language of work or name

English

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publication date

1 August 2014

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30 July 2017

published in

Clinical Cancer Research

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30 July 2017

volume

20

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30 July 2017

issue

16

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30 July 2017

page(s)

4274-4288

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describes a project that uses

30 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4135446/fullTextXML

inferred from PubMed Central ID database lookup

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28 July 2018

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28 July 2018

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Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer

28 July 2018

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TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Integrative analysis of DNA copy number and gene expression in metastatic oral squamous cell carcinoma identifies genes associated with poor survival

28 July 2018

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28 July 2018

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Nek4 status differentially alters sensitivity to distinct microtubule poisons

28 July 2018

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Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

28 July 2018

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Statistical methods for analysis of high-throughput RNA interference screens

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases

28 July 2018

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Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis

28 July 2018

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Targeting epidermal growth factor receptor and SRC pathways in head and neck cancer

28 July 2018

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TP53 mutations and survival in squamous-cell carcinoma of the head and neck.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Multistep skin cancer in mice as a model to study the evolution of cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Targeted expression of c-Src in epidermal basal cells leads to enhanced skin tumor promotion, malignant progression, and metastasis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

The p53 network in head and neck cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Systematic identification of genomic markers of drug sensitivity in cancer cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Aurora kinase inhibitors as anticancer molecules

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Tumor suppression by p53 in the absence of Atm.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

p19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Loss of p53 expression correlates with metastatic phenotype and transcriptional profile in a new mouse model of head and neck cancer.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Expression profiling reveals off-target gene regulation by RNAi

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135446

Reliable detection of p53 aberrations in squamous cell carcinomas of the head and neck requires transcript analysis of the entire coding region

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25125259

12 December 2020

inferred from PubMed ID database lookup

4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Inhibitors of the Checkpoint Kinase Wee1. Structure−Activity Relationships for Chromophore Modification and Phenyl Ring Substitution

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25125259

12 December 2020

inferred from PubMed ID database lookup

Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25125259

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1158/1078-0432.CCR-13-2858

1 reference

30 July 2017

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30 July 2017

1 reference