(Q34058365)

English

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Middle East respiratory syndrome coronavirus

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based on heuristic

inferred from title

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Middle East respiratory syndrome

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based on heuristic

inferred from title

object named as

Eric J Snijder

9

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object named as

Dirk Jochmans

2

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object named as

Johan Neyts

8

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Jessika C Zevenhoven-Dobbe

4

object named as

Jessika C Zevenhoven-Dobbe

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Clara C Posthuma

3

object named as

Clara C Posthuma

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Theo M Bestebroer

6

object named as

Theo M Bestebroer

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

author name string

Adriaan H de Wilde

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Stefan van Nieuwkoop

5

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Bernadette G van den Hoogen

7

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

language of work or name

0 references

publication date

19 May 2014

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

number of pages

10

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based on heuristic

inferred from page(s)

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

PubMed publication ID

30 July 2017

58

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Europe PubMed Central

PubMed publication ID

30 July 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

4875-4884

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Rapid generation of a mouse model for Middle East respiratory syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

1 reference

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5 July 2018

Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus

1 reference

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5 July 2018

A decade after SARS: strategies for controlling emerging coronaviruses

1 reference

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5 July 2018

Middle East respiratory syndrome coronavirus in bats, Saudi Arabia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS.

1 reference

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5 July 2018

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Characterization of a novel betacoronavirus related to middle East respiratory syndrome coronavirus in European hedgehogs

1 reference

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5 July 2018

Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques

1 reference

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5 July 2018

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Clinical management and infection control of SARS: lessons learned

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Severe acute respiratory syndrome (SARS): lessons learnt in Hong Kong

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Chloroquine: modes of action of an undervalued drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

A systematic screen of FDA-approved drugs for inhibitors of biological threat agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Pneumonia from human coronavirus in a macaque model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents

1 reference

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5 July 2018

Suppression of feline coronavirus replication in vitro by cyclosporin A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Reverse genetics of SARS-related coronavirus using vaccinia virus-based recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Recent developments in anti-severe acute respiratory syndrome coronavirus chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Cyclosporin A inhibits the replication of diverse coronaviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Dendritic cell-specific antigen delivery by coronavirus vaccine vectors induces long-lasting protective antiviral and antitumor immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Adipose tissue as a target of HIV-1 antiretroviral drugs. Potential consequences on metabolic regulations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Antiviral activity of chloroquine against human coronavirus OC43 infection in newborn mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats

1 reference

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5 July 2018

Drug targets in severe acute respiratory syndrome (SARS) virus and other coronavirus infections

1 reference

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5 July 2018

Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

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A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Effect of chloroquine on lysosomes and on growth of mouse hepatitis virus (MHV-3).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

The management of coronavirus infections with particular reference to SARS.

1 reference

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5 July 2018

Mouse hepatitis virus type 2 enters cells through a clathrin-mediated endocytic pathway independent of Eps15

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Pharmacologic treatment of SARS: current knowledge and recommendations.

1 reference

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5 July 2018

Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Avian infectious bronchitis virus enters cells via the endocytic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

SARS: systematic review of treatment effects

1 reference

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5 July 2018

Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Design of wide-spectrum inhibitors targeting coronavirus main proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Potent inhibition of SARS-associated coronavirus (SCOV) infection and replication by type I interferons (IFN-alpha/beta) but not by type II interferon (IFN-gamma).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Small molecules targeting severe acute respiratory syndrome human coronavirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Effects of chloroquine on viral infections: an old drug against today's diseases?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136071

5 July 2018

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

1 reference

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5 July 2018

Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation

1 reference

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5 July 2018

Entry of mouse hepatitis virus 3 into cells

1 reference

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5 July 2018

Pharmacology of Antidiarrheal Drugs

1 reference

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5 July 2018

Neuroleptic Concentrations and Clinical Response

1 reference

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5 July 2018

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1 reference

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Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study

1 reference

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28 October 2018

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1 reference

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28 October 2018

Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models

1 reference

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28 October 2018

Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques

1 reference

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28 October 2018

Individual and common inhibitors of coronavirus and picornavirus main proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24841269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Population pharmacokinetics of lopinavir/ritonavir (Kaletra) in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/24841269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapies for coronaviruses. Part I of II -- viral entry inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24841269

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.03011-14

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

0 references

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