(Q34089131)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20024066%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

review article

1 reference

title

Small-molecule modulators of the Sonic Hedgehog signaling pathway (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20024066%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20024066%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Lee F Peng

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20024066%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

publication date

27 August 2009

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15 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20024066%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

volume

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20024066%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

page(s)

44-54

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20024066%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

issue

1

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Hedgehog signaling in animal development: paradigms and principles

15 January 2020

cites work

1 reference

Mutations affecting segment number and polarity in Drosophila

21 January 2018

1 reference

Mapping sonic hedgehog-receptor interactions by steric interference

21 January 2018

1 reference

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

21 January 2018

1 reference

A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form.

21 January 2018

1 reference

Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

21 January 2018

1 reference

Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos

21 January 2018

1 reference

A transmembrane motif governs the surface trafficking of nicotinic acetylcholine receptors

21 January 2018

1 reference

Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus

21 January 2018

1 reference

Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development

21 January 2018

1 reference

Shh expression is required for embryonic hair follicle but not mammary gland development

21 January 2018

1 reference

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

21 January 2018

1 reference

A positive feedback loop coordinates growth and patterning in the vertebrate limb.

21 January 2018

1 reference

Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.

21 January 2018

1 reference

Functional compensation in Hedgehog signaling during mouse prostate development

21 January 2018

1 reference

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

21 January 2018

1 reference

Regulation of patched by sonic hedgehog in the developing neural tube

21 January 2018

1 reference

Constitutive activation of the shh-ptc1 pathway by a patched1 mutation identified in BCC.

21 January 2018

1 reference

Medulloblastoma growth inhibition by hedgehog pathway blockade

21 January 2018

1 reference

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

21 January 2018

1 reference

Basal cell carcinomas in mice overexpressing sonic hedgehog

21 January 2018

1 reference

Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.

21 January 2018

1 reference

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

1 reference

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

1 reference

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

21 January 2018

1 reference

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

21 January 2018

1 reference

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

21 January 2018

1 reference

A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog

21 January 2018

1 reference

Biochemical evidence that patched is the Hedgehog receptor

21 January 2018

1 reference

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

21 January 2018

1 reference

Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway

21 January 2018

1 reference

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

21 January 2018

1 reference

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

21 January 2018

1 reference

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

21 January 2018

1 reference

The primary cilium in cell signaling and cancer

21 January 2018

1 reference

The primary cilium as the cell's antenna: signaling at a sensory organelle

21 January 2018

1 reference

Hedgehog signalling in the mouse requires intraflagellar transport proteins

21 January 2018

1 reference

Vertebrate Smoothened functions at the primary cilium

21 January 2018

1 reference

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

21 January 2018

1 reference

Patched1 regulates hedgehog signaling at the primary cilium

21 January 2018

1 reference

Teratogen-mediated inhibition of target tissue response to Shh signaling.

21 January 2018

1 reference

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

1 reference

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

1 reference

Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription

21 January 2018

1 reference

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

21 January 2018

1 reference

A small molecule that binds Hedgehog and blocks its signaling in human cells

21 January 2018

1 reference

Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays.

21 January 2018

1 reference

Generating Diverse Skeletons of Small Molecules Combinatorially

21 January 2018

1 reference

Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes.

21 January 2018

1 reference

A robust small-molecule microarray platform for screening cell lysates

21 January 2018

1 reference

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells

21 January 2018

1 reference

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

21 January 2018

1 reference

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

21 January 2018

1 reference

Small molecule modulation of Smoothened activity

21 January 2018

1 reference

A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells

21 January 2018

1 reference

Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway

21 January 2018

1 reference

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

21 January 2018

1 reference

Basal cell carcinomas: attack of the hedgehog

21 January 2018

1 reference

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

21 January 2018

1 reference

Hedgehog-Gli signaling pathway inhibitors as anticancer agents.

21 January 2018

1 reference

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

21 January 2018

1 reference

A role for chemistry in stem cell biology

21 January 2018

1 reference