(Q34093038)

31 July 2017

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title

Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design (English)

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31 July 2017

Kakali Bhadra

1

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PubMed ID

20077560

31 July 2017

Gopinatha Suresh Kumar

series ordinal

2

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31 July 2017

14 January 2010

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Medicinal Research Reviews

31 July 2017

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31 July 2017

31

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31 July 2017

6

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31 July 2017

821-862

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Quaternary protoberberine alkaloids.

31 July 2017

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The potential of alkaloids in drug discovery

21 January 2018

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Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores.

21 January 2018

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Uncoupling of photosynthetic phosphorylation by benzophenanthridine alkaloids

21 January 2018

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DNA relaxation and cleavage assays to study topoisomerase I inhibitors

21 January 2018

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Human topoisomerase I poisoning: docking protoberberines into a structure-based binding site model

21 January 2018

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Biochemical effects of berberine

21 January 2018

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Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

21 January 2018

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Interaction of berberine with human platelet alpha 2 adrenoceptors

21 January 2018

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Mechanism of vasodilatory effect of berberine in rat mesenteric artery

21 January 2018

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Effect of berberine on Staphylococcus epidermidis biofilm formation

21 January 2018

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Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage.

21 January 2018

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Berberine-antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells.

21 January 2018

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Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.

21 January 2018

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Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte.

21 January 2018

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The anti-inflammatory potential of berberine in vitro and in vivo

21 January 2018

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Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model

21 January 2018

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L-Glutamine influx in malaria-infected erythrocytes: a target for antimalarials?

21 January 2018

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Leishmania donovani: amastigote inhibition and mode of action of berberine

21 January 2018

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Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats

21 January 2018

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Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK.

21 January 2018

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Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action

21 January 2018

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Effects of berberine on glucose metabolism in vitro

21 January 2018

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Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus

21 January 2018

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Effects of palmatine on potassium and calcium currents in isolated rat hepatocytes

21 January 2018

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Hepatobiliary excretion of berberine

21 January 2018

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Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

21 January 2018

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The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms

21 January 2018

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Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion

21 January 2018

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Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression

21 January 2018

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Effect of berberine on barrier function in a human retinal pigment epithelial cell line

21 January 2018

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Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.

21 January 2018

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Ca(2+)-activated K+ channel is present in guinea-pig but lacking in rat hepatocytes

21 January 2018

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Plasma membrane Ca2+ release-activated Ca2+ channels with a high selectivity for Ca2+ identified by patch-clamp recording in rat liver cells

21 January 2018

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Palmatine, a protoberberine alkaloid, inhibits both Ca(2+)- and cAMP-activated Cl(-) secretion in isolated rat distal colon

21 January 2018

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The mechanism of guanine specific photooxidation in the presence of berberine and palmatine: activation of photosensitized singlet oxygen generation through DNA-binding interaction

21 January 2018

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Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine

21 January 2018

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In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids.

21 January 2018

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Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids

21 January 2018

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Hypoglycemic activity of jatrorrhizine

21 January 2018

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Synthesis and antimicrobial activity of 3-alkoxyjatrorrhizine derivatives

21 January 2018

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Synthesis and antimicrobial activity of 3-octyloxy-8-alkyljatrorrhizine derivatives

21 January 2018

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Cross resistance pattern towards anticancer drugs of a human carcinoma multidrug-resistant cell line

21 January 2018

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Inhibition of topoisomerase I function by coralyne and 5,6-dihydrocoralyne

21 January 2018

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21 January 2018

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Efficient photoinduced DNA damage by coralyne.

21 January 2018

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Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.)

21 January 2018

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Sanguinarine, a phototoxic H2O2-producing alkaloid.

21 January 2018

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Phototoxic and photochemical properties of sanguinarine

21 January 2018

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Cytotoxicity of sanguinarine chloride to cultured human cells from oral tissue

21 January 2018

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Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation

21 January 2018

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Bax, Bcl-2, and NF-kappaB expression in sanguinarine induced bimodal cell death

21 January 2018

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Sanguinarine: an evaluation of in vivo cytogenetic activity

21 January 2018

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The alkaloid sanguinarine is effective against multidrug resistance in human cervical cells via bimodal cell death

21 January 2018

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Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells

21 January 2018

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The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding. A possible mechanism for its antiproliferative activity.

21 January 2018

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Suppression of angiogenesis by the plant alkaloid, sanguinarine

21 January 2018

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The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.

21 January 2018

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Correlation of the cytotoxic activity of four different alkaloids, from Chelidonium majus (greater celandine), with their DNA intercalating properties and ability to induce breaks in the DNA of NK/Ly murine lymphoma cells

21 January 2018

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Sanguinarine causes DNA damage and p53-independent cell death in human colon cancer cell lines

21 January 2018

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Aurintricarboxylic acid inhibits protein synthesis independent, sanguinarine-induced apoptosis and oncosis.

21 January 2018

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Sanguinarine, a benzophenanthridine alkaloid, induces apoptosis in MDA-MB-231 human breast carcinoma cells through a reactive oxygen species-mediated mitochondrial pathway

21 January 2018

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Sanguinarine induces apoptosis in A549 human lung cancer cells primarily via cellular glutathione depletion

21 January 2018

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Synthesis and DNA-binding affinities of monomodified berberines

21 January 2018

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Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions

21 January 2018

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Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities.

21 January 2018

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Spacer length and attaching position-dependent binding of synthesized protoberberine dimers to double-stranded DNA.

21 January 2018

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Quaternary benzo[c]phenanthridine alkaloids--novel cell permeant and red fluorescing DNA probes.

21 January 2018

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Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine

21 January 2018

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Fluorescence properties of selected benzo[c]phenantridine alkaloids and studies of their interaction with CT DNA.

21 January 2018

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DNA Modification and Cancer

21 January 2018

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The search of DNA-intercalators as antitumoral drugs: what it worked and what did not work.

21 January 2018

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Molecular aspects on the interaction of protoberberine, benzophenanthridine, and aristolochia group of alkaloids with nucleic acid structures and biological perspectives

21 January 2018

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DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action

21 January 2018

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Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges

21 January 2018

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Rational ligand design for RNA: the role of static structure and conformational flexibility in target recognition

21 January 2018

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Towards the discovery of drug-like RNA ligands?

21 January 2018

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Molecular aspects of small molecules-poly(A) interaction: an approach to RNA based drug design

21 January 2018

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The interaction of plant alkaloids with DNA. II. Berberinium chloride

21 January 2018

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Mode of binding of the cytotoxic alkaloid berberine with the double helix oligonucleotide d(AAGAATTCTT)(2).

21 January 2018

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Protonated forms of poly[d(G-C)] and poly(dG).poly(dC) and Their interaction with berberine

21 January 2018

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Protonated structures of naturally occurring deoxyribonucleic acids and their interaction with berberine.

21 January 2018

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Interaction of isoquinoline alkaloids with polymorphic DNA structures

21 January 2018

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9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA.

21 January 2018

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Self-structure induction in single stranded poly(A) by small molecules: Studies on DNA intercalators, partial intercalators and groove binding molecules

21 January 2018

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Molecular recognition of poly(A) by small ligands: an alternative method of analysis reveals nanomolar, cooperative and shape-selective binding

21 January 2018

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Spectroscopic and calorimetric studies on the binding of alkaloids berberine, palmatine and coralyne to double stranded RNA polynucleotides

21 January 2018

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The binding of DNA intercalating and non-intercalating compounds to A-form and protonated form of poly(rC).poly(rG): spectroscopic and viscometric study

21 January 2018

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Spectroscopic and thermodynamic studies on the binding of sanguinarine and berberine to triple and double helical DNA and RNA structures

21 January 2018

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Interaction of isoquinoline alkaloids with an RNA triplex: structural and thermodynamic studies of berberine, palmatine, and coralyne binding to poly(U).poly(A)(*)poly(U).

21 January 2018

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Spectrometric studies of cytotoxic protoberberine alkaloids binding to double-stranded DNA.

21 January 2018

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Synthesis, DNA-binding affinities, and binding mode of berberine dimers

21 January 2018

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Cytotoxicity and DNA binding properties of the plant alkaloid burasaine

21 January 2018

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Interaction of isoquinoline alkaloid palmatine with deoxyribonucleic acids: binding heterogeneity, and conformational and thermodynamic aspects

21 January 2018

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Study on the phosphorescence characterizations of palmatine chloride on the solid substrate and its interaction with ctDNA.

21 January 2018

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RNA specific molecules: cytotoxic plant alkaloid palmatine binds strongly to poly(A).

21 January 2018

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Solvent effects on the thermodynamics and kinetics of coralyne self-aggregation

21 January 2018

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Complete disproportionation of duplex poly(dT)*poly(dA) into triplex poly(dT)*poly(dA)*poly(dT) and poly(dA) by coralyne

21 January 2018

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Controlling nucleic acid secondary structure by intercalation: effects of DNA strand length on coralyne-driven duplex disproportionation

21 January 2018

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Molecular recognition of nucleic acids: coralyne binds strongly to poly(A).

21 January 2018

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RNA targeting through binding of small molecules: Studies on t-RNA binding by the cytotoxic protoberberine alkaloid coralyne

21 January 2018

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Small molecule-RNA interaction: spectroscopic and calorimetric studies on the binding by the cytotoxic protoberberine alkaloid coralyne to single stranded polyribonucleotides

21 January 2018

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Influence of DNA structures on the conversion of sanguinarine alkanolamine form to iminium form

21 January 2018

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Sequence-selective, pH-dependent binding to DNA of benzophenanthridine alkaloids

21 January 2018

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Biophysical aspects and biological implications of the interaction of benzophenanthridine alkaloids with DNA.

21 January 2018

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Interaction of the antileukemic alkaloid, 2-hydroxy-3,8,9-trimethoxy-5-methylbenzo[c]phenanthridine (fagaronine), with nucleic acids

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.20202

1 reference

31 July 2017

1 reference

PubMed ID

20077560