(Q34096644)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

14

1 reference

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18 January 2020

author name string

Hung-Kai Chen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Zhaoping Liu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Anke Meyer-Franke

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Jens Brodbeck

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Rene D Miranda

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

James G McGuire

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Michael A Pleiss

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Zhong-Sheng Ji

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Maureen E Balestra

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

David W Walker

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Qin Xu

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Dah-eun Jeong

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Madhu S Budamagunta

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Stephen B Freedman

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Karl H Weisgraber

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Yadong Huang

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Robert W Mahley

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

English

0 references

publication date

12 December 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

18 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

287

1 reference

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18 January 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

5253-5266

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

18 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3285306/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors

1 reference

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C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice

5 July 2018

1 reference

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Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

5 July 2018

1 reference

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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

5 July 2018

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Tau reduction prevents Abeta-induced defects in axonal transport.

5 July 2018

1 reference

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Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease

5 July 2018

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Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

5 July 2018

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Influence of cell background on pharmacological rescue of mutant CFTR.

5 July 2018

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GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice

5 July 2018

1 reference

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Awakening guardian angels: drugging the p53 pathway

5 July 2018

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The pharmacological chaperone 1-deoxygalactonojirimycin reduces tissue globotriaosylceramide levels in a mouse model of Fabry disease

5 July 2018

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PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

5 July 2018

1 reference

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The pharmacological chaperone 1-deoxygalactonojirimycin increases alpha-galactosidase A levels in Fabry patient cell lines

5 July 2018

1 reference

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Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease

5 July 2018

1 reference

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Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure

5 July 2018

1 reference

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Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

5 July 2018

1 reference

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Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice

5 July 2018

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CFTR function and prospects for therapy

5 July 2018

1 reference

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Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Molecule-pharmacophore superpositioning and pattern matching in computational drug design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Restoration of p53 to limit tumor growth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder

5 July 2018

1 reference

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Pharmacophore modeling and three dimensional database searching for drug design using catalyst: recent advances

5 July 2018

1 reference

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Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Neuronal nicotinic acetylcholine receptor agonists: pharmacophores, evolutionary QSAR and 3D-QSAR models

5 July 2018

1 reference

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Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

5 July 2018

1 reference

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Therapeutic approaches to protein-misfolding diseases

5 July 2018

1 reference

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Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Creating new fluorescent probes for cell biology.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

A review of molecular modeling approaches to pharmacophore models and structure-activity relationships of ion channel modulators in CNS.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

5 July 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Apolipoprotein E and cognitive performance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Apolipoprotein E: structure-function relationships

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Synthesis and processing of alpha-galactosidase A in human fibroblasts. Evidence for different mutations in Fabry disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285306

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

5 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Engineering conformational destabilization into mouse apolipoprotein E. A model for a unique property of human apolipoprotein E4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Chemical function-based pharmacophore development for novel, selective kappa opioid receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Transgenic mouse expressing human mutant alpha-galactosidase A in an endogenous enzyme deficient background: a biochemical animal model for studying active-site specific chaperone therapy for Fabry disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Cellular and tissue localization of globotriaosylceramide in Fabry disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.276162

Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms

21 January 2018

1 reference

12 December 2020

Pharmacological rescue of mutant p53 conformation and function

1 reference

12 December 2020

Cell-Based Screening of Active-Site Specific Chaperone for the Treatment of Fabry Disease

1 reference

12 December 2020

1 reference

12 December 2020

Enzymatic Defect in Fabry's Disease

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.276162

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

release_rwvjczeipbfz7ddnntyicw3c6m

18 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rwvjczeipbfz7ddnntyicw3c6m

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22158868%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

22158868

1 reference