(Q40621541)

22 September 2017

Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease (English)

1 reference

22 September 2017

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1 reference

7

Tony Wyss-Coray

1 reference

22 September 2017

Faith M Harris

1

1 reference

22 September 2017

Ina Tesseur

2

1 reference

22 September 2017

Walter J Brecht

3

1 reference

22 September 2017

Qin Xu

4

1 reference

22 September 2017

Karin Mullendorff

5

1 reference

22 September 2017

Shengjun Chang

6

1 reference

22 September 2017

Robert W Mahley

8

1 reference

22 September 2017

Yadong Huang

9

1 reference

22 September 2017

language of work or name

English

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publication date

29 October 2003

1 reference

Journal of Biological Chemistry

22 September 2017

7

1 reference

based on heuristic

inferred from page(s)

published in

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22 September 2017

279

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22 September 2017

3862-3868

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22 September 2017

5

1 reference

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

22 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E alleles as risk factors in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

The molecular pathology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

New frontiers in Alzheimer's disease genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E receptors: linking brain development and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Truncated apoE forms tangle-like structures in a neuronal cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Sialylated human apolipoprotein E (apoEs) is preferentially associated with neuron-enriched cultures from APOE transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Specific regional transcription of apolipoprotein E in human brain neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Regionally specific neuronal expression of human APOE gene in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Synthesis and processing of apolipoprotein E in human brain cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

ApoE synthesis in human neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

BDNF stimulates expression, activity and release of tissue-type plasminogen activator in mouse cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Human brain S100 beta and S100 beta mRNA expression increases with age: pathogenic implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Glial reaction in the hippocampal formation is highly correlated with aging in human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Regionally specific loss of neurons in the aging human hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Quantitative synaptic alterations in the human neocortex during normal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Molecular profile of reactive astrocytes--implications for their role in neurologic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Early association of reactive astrocytes with senile plaques in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Seeding of vascular grafts with genetically modified endothelial cells. Secretion of recombinant TPA results in decreased seeded cell retention in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Senile dementia of Alzheimer type: astroglial reaction to extracellular neurofibrillary tangles in the hippocampus. An immunocytochemical and electron-microscopic study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Interleukin-6 and α-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Isolation and characterization of apolipoprotein B-48 and B-100 very low density lipoproteins from type III hyperlipoproteinemic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Intracellular signaling pathways activated by neurotrophic factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Mitotic mechanisms in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

The cell division cycle and the pathophysiology of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Association of active extracellular signal-regulated protein kinase with paired helical filaments of inclusion-body myositis muscle suggests its role in inclusion-body myositis tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Increased plasma apolipoprotein E (apoE) levels in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

The --491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E promoter polymorphism and sporadic Alzheimer's disease in a Japanese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

The human apolipoprotein E gene is negatively regulated in human liver HepG2 cells by the transcription factor BEF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Duplicated downstream enhancers control expression of the human apolipoprotein E gene in macrophages and adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Expression of the apolipoprotein E gene in the skin is controlled by a unique downstream enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E: far more than a lipid transport protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309475200

21 January 2018

Identifiers

DOI

10.1074/JBC.M309475200

1 reference

22 September 2017

1 reference