(Q34102882)

31 July 2017

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title

Strategies and testing methods for identifying mutagenic risks (English)

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31 July 2017

MacGregor JT

1

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31 July 2017

Casciano D

series ordinal

2

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31 July 2017

Müller L

series ordinal

3

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31 July 2017

language of work or name

English

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publication date

1 November 2000

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31 July 2017

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31 July 2017

volume

455

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31 July 2017

issue

1-2

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31 July 2017

page(s)

3-20

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Chemical Production of Mutations

31 July 2017

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Target organ and time-course in the mutagenicity of five carcinogens in MutaMouse: a summary report of the second collaborative study of the transgenic mouse mutation assay by JEMS/MMS.

7 January 2021

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7 January 2021

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Kinetics of induction of DNA adducts, cell proliferation and gene mutations in the liver of MutaMice treated with 5,9-dimethyldibenzo[c,g]carbazole

7 January 2021

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Effect of mitogenic or regenerative cell proliferation on lacz mutant frequency in the liver of MutaTMMice treated with 5, 9-dimethyldibenzo[c,g]carbazole.

7 January 2021

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Diethylnitrosamine exposure-responses for DNA ethylation, hepatocellular proliferation, and initiation of carcinogenesis in rat liver display non-linearities and thresholds

7 January 2021

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Kinetics of DNA adduct formation and removal in mouse hepatocytes following in vivo exposure to 5,9-dimethyldibenzo[c,g]carbazole

7 January 2021

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Series: current issues in mutagenesis and carcinogenesis, No. 65. The genotoxicity and carcinogenicity of paracetamol: a regulatory (re)view

7 January 2021

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Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection

7 January 2021

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Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals

7 January 2021

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Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Cytotoxicity and chromosome aberrations in vitro: experience in industry and the case for an upper limit on toxicity in the aberration assay

7 January 2021

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Too many rodent carcinogens: mitogenesis increases mutagenesis

7 January 2021

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Challenge to the simple paradigm that 'carcinogens' are 'mutagens' and to the in vitro and in vivo assays used to test the paradigm

7 January 2021

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Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP.

7 January 2021

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7 January 2021

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Carcinogenicity results for 114 laboratory animal studies used to assess the predictivity of four in vitro genetic toxicity assays for rodent carcinogenicity

7 January 2021

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Transgenic animal models for mutagenesis studies: role in mutagenesis research and regulatory testing

7 January 2021

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7 January 2021

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7 January 2021

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Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test

7 January 2021

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Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: industrial experience

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Somatic cell mutation detection and quantification of X-ray-induced mutation in cultured, diploid human fibroblasts

7 January 2021

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A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): development and definition of the system

7 January 2021

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Cytotoxicity and mutagenicity of alkylating agents in cultured mammalian cells (CHO/HGPRT system): Mutagen treatment in the presence or absence of serum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Phenotypic lag and mutation to 6-thioguanine resistance in diploid human lymphoblasts

7 January 2021

1 reference

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The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals. A report of the gene-tox program

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Mammalian in vivo cytogenetic assays. Analysis of chromosome aberrations in bone marrow cells.

7 January 2021

1 reference

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Lifetime persistence and clonality of chromosome aberrations in the peripheral blood of mice acutely exposed to ionizing radiation

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Numerical and structural chromosomal abnormalities detected in human sperm with a combination of multicolor FISH assays

7 January 2021

1 reference

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Fluorescence in situ hybridization to Y chromosomes in decondensed human sperm nuclei

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Detection of hyperdiploidy and chromosome breakage in interphase human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolor fluorescence in situ hybridization with DNA probes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Enumeration of 6-thioguanine-resistant peripheral blood lymphocytes in man as a potential test for somatic cell mutations arising in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

In vivo somatic mutations in humans: measurement and analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Somatic gene mutations in vivo as indicated by the 6-thioguanine-resistant T-lymphocytes in human blood.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Enumeration of thioguanine-resistant lymphocytes using autoradiography.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Detection of somatic mutants in man: HPRT mutations in lymphocytes and hemoglobin mutations in erythrocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Autoradiographic detection of 6-thioguanine-resistant lymphocytes of mice. A novel system in somatic mutagenesis testing.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Factors that affect the frequency of thioguanine-resistant lymphocytes in mice following exposure to ethylnitrosourea

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Measurement of in vivo mutant frequency in lymphocytes in the mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

A further assessment of factors influencing measurements of thioguanine-resistant mutant frequency in circulating T-lymphocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Factors influencing mutation at the hprt locus in T-lymphocytes: studies in normal women and women with benign and malignant breast masses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

The mutagenic effects of low level sub-acute inhalation exposure to benzene in CD-1 mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Induction of hprt mutations in mice after exposure to fission-spectrum neutrons or 60Co gamma rays

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Molecular analysis of hypoxanthine phosphoribosyl transferase mutants induced by glycidyl 1-naphthyl ether in mouse spleen cells in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

A mouse model for the study of in vivo mutational spectra: sequence specificity of ethylene oxide at the hprt locus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene, 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F1 mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Development of a cloning assay with high cloning efficiency to detect induction of 6-thioguanine-resistant lymphocytes in spleen of adult mice following in vivo inhalation exposure to 1,3-butadiene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Mutant frequency at the H-2K class 1 and HPRT genes in T lymphocytes from the X-ray-exposed mouse.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

The effect of time after treatment, treatment schedule and animal age on the frequency of 6-thioguanine-resistant T-lymphocytes induced in Fischer 344 rats by N-ethyl-N-nitrosourea.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Development and utilization of the rat lymphocyte hprt mutation assay

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Lymphocyte mutant frequency in relation to DNA adduct formation in rats treated with tumorigenic doses of the mammary gland carcinogen 7,12-dimethylbenz[a]anthracene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Calorie restriction modulates chemically induced in vivo somatic mutation frequency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Induction of hprt gene mutations in splenic T-lymphocytes from the rat exposed in vivo to DNA methylating agents is correlated with formation of O6-methylguanine in bone marrow and not in the spleen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

LacZ transgenic mouse models: their application in genetic toxicology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Transgenic Animal Models for Detection of In Vivo Mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

In vivo transgenic mutation assays

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Comparison of somatic mutation in a transgenic versus host locus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue(R) rats treated with 7, 12-dimethylbenz[a]anthracene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

ENU-induced mutagenesis at a single A: T base pair in transgenic mice containing phi X174.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Induction of lacZ mutation by 7,12-dimethylbenz[a]anthracene in various tissues of transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

4-chloro-o-phenylenediamine induces a dose-related increase in G:C > T:A transversions and one major DNA adduct in the liver of Big Blue mice after 26 weeks in feed treatment.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Mutagenic activity of 4-nitroquinoline-N-oxide in upper aerodigestive tissue in lacZ mice (MutaMouse) and the effects of 1, 4-phenylenebis(methylene)selenocyanate.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Increase in mutation frequency in lung of Big Blue rat by exposure to diesel exhaust.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

LacI mutation spectra following benzo[a]pyrene treatment of Big Blue mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Mutational analysis of the liver, colon and kidney of Big Blue rats treated with 2-amino-3-methylimidazo[4,5-f]quinoline.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue B6C3F1 mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Assessment of the in vivo mutagenicity of ethylene oxide in the tissues of B6C3F1 lacI transgenic mice following inhalation exposure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lacI transgenic mice following inhalation exposure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

APRT: a versatile in vivo resident reporter of local mutation and loss of heterozygosity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Development of a novel mouse tk+/- embryonic stem cell line for use in mutagenicity studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

A mutational assay system using the thymidine kinase locus in mouse lymphoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

High-frequency nonrandom mutational event at the adenine phosphoribosyltransferase (aprt) locus of sib-selected CHO variants heterozygous for aprt.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Isolation of an APRT heterozygote from TK6 human lymphoblasts: predominance of multi-locus loss of heterozygosity among spontaneous APRT-mutants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Genotypic selection methods for the direct analysis of point mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

Global response of Saccharomyces cerevisiae to an alkylating agent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2800%2900116-0

10.1016/S0027-5107(00)00116-0

7 January 2021

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DOI

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31 July 2017

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