(Q34103998)

English

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

0 references

colorectal cancer

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

colorectal carcinoma

1 reference

based on heuristic

inferred from title

Aimery de Gramont

5

object named as

Aimery de Gramont

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Virginie Poindessous

2

object named as

Virginie Poindessous

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author name string

Paul Mésange

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Michèle Sabbah

3

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Alexandre E Escargueil

4

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Annette K Larsen

6

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

language of work or name

0 references

publication date

1 July 2014

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

13

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

4709-4721

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer

1 reference

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1 reference

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Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells

1 reference

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Prognostic and predictive value of VEGF, sVEGFR-2 and CEA in mCRC studies comparing cediranib, bevacizumab and chemotherapy

1 reference

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Rapid decrease in tumor perfusion following VEGF blockade predicts long-term tumor growth inhibition in preclinical tumor models

1 reference

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Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors.

1 reference

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Passing the baton: the HIF switch

1 reference

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Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia

1 reference

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Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model.

1 reference

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1 reference

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Chronic exposure of colorectal cancer cells to bevacizumab promotes compensatory pathways that mediate tumour cell migration

1 reference

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Intracrine vascular endothelial growth factor signaling in survival and chemoresistance of human colorectal cancer cells

1 reference

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Targeting the tumour vasculature: insights from physiological angiogenesis

1 reference

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Blocking effects of siRNA on VEGF expression in human colorectal cancer cells

1 reference

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Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer

1 reference

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mTOR signaling at a glance

1 reference

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Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study

1 reference

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Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148093

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BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy

1 reference

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A novel tumor-promoting function residing in the 5' non-coding region of vascular endothelial growth factor mRNA

1 reference

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1 reference

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Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells

1 reference

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Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells

1 reference

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Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.

1 reference

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Short interfering RNA-mediated gene silencing of vascular endothelial growth factor: effects on cellular proliferation in colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148093

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A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148093

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Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148093

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Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148093

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Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

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Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148093

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Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status.

1 reference

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Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs.

1 reference

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EGFR- and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies.

1 reference

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VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal cancer [corrected] patients.

1 reference

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Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors

1 reference

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Vascular endothelial growth factor receptor expression as a prognostic marker for survival in colorectal cancer.

1 reference

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1 reference

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Activated VEGFR2/KDR pathway in tumour cells and tumour associated vessels of colorectal cancer

1 reference

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1 reference

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Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25015210

12 December 2020

based on heuristic

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Identifiers

10.18632/ONCOTARGET.1671

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

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