(Q34104118)

31 July 2017

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title

Von Hippel-Lindau syndrome: molecular mechanisms of the disease (English)

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31 July 2017

María J Calzada

1

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31 July 2017

publication date

1 March 2010

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Clinical and Translational Oncology

31 July 2017

published in

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31 July 2017

volume

12

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31 July 2017

issue

3

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31 July 2017

page(s)

160-165

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The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

31 July 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS12094-010-0485-9

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS12094-010-0485-9

Ectopic expression of von Hippel-Lindau tumor suppressor induces apoptosis in 786-O renal cell carcinoma cells and regresses tumor growth of 786-O cells in nude mouse

21 January 2018

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12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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12 December 2020

Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.

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12 December 2020

von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis

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12 December 2020

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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12 December 2020

Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

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12 December 2020

Molecular basis of the VHL hereditary cancer syndrome

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12 December 2020

KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport

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12 December 2020

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

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12 December 2020

VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells.

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12 December 2020

Role of the von Hippel-Lindau tumor suppressor gene in the formation of beta1-integrin fibrillar adhesions

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12 December 2020

Beta-catenin gets jaded and von Hippel-Lindau is to blame

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12 December 2020

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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12 December 2020

Polycystins and mechanosensation in renal and nodal cilia

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12 December 2020

Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein

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12 December 2020

Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease.

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12 December 2020

The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth

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12 December 2020

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

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12 December 2020

A conserved family of prolyl-4-hydroxylases that modify HIF

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12 December 2020

Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility

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12 December 2020

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

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12 December 2020

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

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12 December 2020

von Hippel-Lindau protein promotes the assembly of actin and vinculin and inhibits cell motility

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12 December 2020

Primary cilium formation requires von hippel-lindau gene function in renal-derived cells

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12 December 2020

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

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12 December 2020

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

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12 December 2020

p53 stabilization and transactivation by a von Hippel-Lindau protein

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12 December 2020

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

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12 December 2020

Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis

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12 December 2020

Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3.

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12 December 2020

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.

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12 December 2020

Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development

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12 December 2020

The von Hippel-Lindau tumor suppressor protein sensitizes renal cell carcinoma cells to tumor necrosis factor-induced cytotoxicity by suppressing the nuclear factor-kappaB-dependent antiapoptotic pathway

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12 December 2020

Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

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12 December 2020

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

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12 December 2020

VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail

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12 December 2020

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

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12 December 2020

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

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12 December 2020

Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis

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12 December 2020

The ins and outs of fibronectin matrix assembly

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12 December 2020

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

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12 December 2020

Sunitinib in patients with metastatic renal cell carcinoma

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12 December 2020

pVHL and GSK3beta are components of a primary cilium-maintenance signalling network

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12 December 2020

von Hippel-Lindau disease

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12 December 2020

Phase I trial of sorafenib in combination with IFN alpha-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma

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12 December 2020

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

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12 December 2020

Identification of the von Hippel-Lindau disease tumor suppressor gene

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12 December 2020

Inadequate activation of the GTPase RhoA contributes to the lack of fibronectin matrix assembly in von Hippel-Lindau protein-defective renal cancer cells

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12 December 2020

Targeting HIF-1 for cancer therapy

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12 December 2020

Anti-VEGF therapy for renal cell carcinoma

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12 December 2020

Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2

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12 December 2020

Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma

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12 December 2020

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

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12 December 2020

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

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12 December 2020

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

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12 December 2020

Fibronectin is a hypoxia-independent target of the tumor suppressor VHL.

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12 December 2020

The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2

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12 December 2020

Allele-specific regulation of primary cilia function by the von Hippel-Lindau tumor suppressor

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12 December 2020

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

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12 December 2020

von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms

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12 December 2020

Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity

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12 December 2020

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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12 December 2020

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

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12 December 2020

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

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12 December 2020

Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

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12 December 2020

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

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12 December 2020

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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12 December 2020

Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor

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12 December 2020

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

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12 December 2020

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

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12 December 2020

Recombinant adenovirus expressing Von Hippel-Lindau-mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1

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12 December 2020

The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1

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12 December 2020

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

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12 December 2020

HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation

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12 December 2020

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2

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12 December 2020

Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent.

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12 December 2020

The von Hippel-Lindau tumour suppressor: a multi-faceted inhibitor of tumourigenesis

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12 December 2020

The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL).

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12 December 2020

pVHL function is essential for endothelial extracellular matrix deposition.

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12 December 2020

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

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12 December 2020

The primary cilium as the cell's antenna: signaling at a sensory organelle

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12 December 2020

pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma.

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12 December 2020

The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis

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12 December 2020

Role of nuclear and cytoplasmic localization in the tumour-suppressor activity of the von Hippel-Lindau protein.

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12 December 2020

Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis

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12 December 2020

Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin

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12 December 2020

Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes

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12 December 2020

Role of VHL gene mutation in human cancer

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12 December 2020

10.1007/S12094-010-0485-9

Identifiers

DOI

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31 July 2017

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