(Q34111028)

31 July 2017

title

Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters (English)

1 reference

31 July 2017

Jamil Kanaani

1

1 reference

31 July 2017

Julia Kolibachuk

series ordinal

2

1 reference

31 July 2017

Hugo Martinez

series ordinal

3

1 reference

31 July 2017

Steinunn Baekkeskov

series ordinal

4

1 reference

31 July 2017

language of work or name

English

0 references

publication date

30 August 2010

1 reference

31 July 2017

published in

Journal of Cell Biology

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31 July 2017

volume

190

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31 July 2017

issue

5

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31 July 2017

page(s)

911-925

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Palmitoylation cycles and regulation of protein function (Review).

31 July 2017

cites work

1 reference

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5 July 2018

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Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice

5 July 2018

1 reference

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GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex

5 July 2018

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GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

5 July 2018

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Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein

5 July 2018

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Kinetic differences between the isoforms of glutamate decarboxylase: implications for the regulation of GABA synthesis

5 July 2018

1 reference

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Demonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles

5 July 2018

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Developmental neurotransmitters?

5 July 2018

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A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65

5 July 2018

1 reference

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Is there more to GABA than synaptic inhibition?

5 July 2018

1 reference

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The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release

5 July 2018

1 reference

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Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

5 July 2018

1 reference

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Local GABA circuit control of experience-dependent plasticity in developing visual cortex.

5 July 2018

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A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS)

5 July 2018

1 reference

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Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

5 July 2018

1 reference

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Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67

5 July 2018

1 reference

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Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region

5 July 2018

1 reference

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Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

5 July 2018

1 reference

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Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

Characterization of a cDNA coding for rat glutamic acid decarboxylase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain

5 July 2018

1 reference

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Structural model of human GAD65: prediction and interpretation of biochemical and immunogenic features

5 July 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200912101

Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200912101

A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200912101

Synaptic localization of the 67,000 mol. wt isoform of glutamate decarboxylase and transmitter function of GABA in the mouse cerebellum lacking the 65,000 mol. wt isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200912101

Altered taste function in mice deficient in the 65-kDa isoform of glutamate decarboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200912101

Two isoforms of glutamate decarboxylase: why?

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200912101

Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200912101

Altered conditioned fear behavior in glutamate decarboxylase 65 null mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200912101

Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935578

High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20805323

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20805323

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.200912101

1 reference

31 July 2017

1 reference

31 July 2017

1 reference