(Q34115152)

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Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

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2 February 2020

Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia (English)

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2 February 2020

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2 February 2020

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2 February 2020

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2 February 2020

Dominic J Withers

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2 February 2020

Michael L Ashford

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2 February 2020

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Kaisa Piipari

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2 February 2020

Hind Al-Qassab

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2 February 2020

Nadeene Parker

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1 July 2010

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2 February 2020

Biochemical Journal

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2 February 2020

429

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2 February 2020

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2 February 2020

323-333

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2 February 2020

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Creative Commons Attribution-NonCommercial 2.5 Generic

25 July 2019

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LKB1 regulates pancreatic beta cell size, polarity, and function

1 reference

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Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells

1 reference

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ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function

1 reference

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AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells

1 reference

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5 July 2018

Metformin--the gold standard in type 2 diabetes: what does the evidence tell us?

1 reference

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5 July 2018

Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the K(ATP) channel and insulin secretion in rats.

1 reference

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5 July 2018

Targeting the AMPK pathway for the treatment of Type 2 diabetes

1 reference

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5 July 2018

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

1 reference

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5 July 2018

On the role of uncoupling protein-2 in pancreatic beta cells.

1 reference

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5 July 2018

Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

1 reference

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5 July 2018

Islet gene expression and function in type 2 diabetes; studies in the Goto-Kakizaki rat and humans

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5 July 2018

An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment.

1 reference

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5 July 2018

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

1 reference

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5 July 2018

Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator

1 reference

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5 July 2018

beta-cell failure in diabetes and preservation by clinical treatment

1 reference

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5 July 2018

The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells

1 reference

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5 July 2018

Mechanisms linking obesity to insulin resistance and type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

5 July 2018

Oxidative stress and impaired insulin secretion in type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

5 July 2018

Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

5 July 2018

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

5 July 2018

AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

5 July 2018

A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells

1 reference

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5 July 2018

Glucose-sensing mechanisms in pancreatic beta-cells.

1 reference

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5 July 2018

ATP-sensitive potassium channelopathies: focus on insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

5 July 2018

The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

1 reference

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5 July 2018

Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation

1 reference

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5 July 2018

5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK.

1 reference

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5 July 2018

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

1 reference

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5 July 2018

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion

1 reference

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Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

1 reference

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Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

1 reference

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Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models

1 reference

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1 reference

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5 July 2018

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1 reference

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5 July 2018

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

1 reference

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5 July 2018

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1 reference

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1 reference

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1 reference

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1 reference

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Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.

1 reference

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Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase

1 reference

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1 reference

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5 July 2018

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

28 October 2018

Glucokinase (GCK) and other susceptibility genes for beta-cell dysfunction: the candidate approach.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

28 October 2018

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

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Fructose metabolism in the adult mouse optic nerve, a central white matter tract.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

28 October 2018

Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

28 October 2018

5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

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Functional and molecular defects of pancreatic islets in human type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895783

28 October 2018

Identifiers

10.1042/BJ20100231

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Europe PubMed Central

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2 February 2020

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Europe PubMed Central

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2 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465544%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

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