(Q30475796)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

The role of insulin receptor substrate 2 in hypothalamic and beta cell function (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Marc Claret

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Kazunari Hisadome

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Michael L Ashford

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

8

Melanie Clements

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

16

John R Speakman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

17

Rachel L Batterham

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

author name string

Agharul I Choudhury

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Helen Heffron

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Hind Al-Qassab

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Allison W Xu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Colin Selman

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Marcus Simmgen

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Gavin Maccoll

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

David C Bedford

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Ivan Diakonov

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Vazira Moosajee

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Jimmy D Bell

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Gregory S Barsh

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Dominic J Withers

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

language of work or name

English

0 references

publication date

24 March 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

11 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

volume

115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

page(s)

940-950

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

PI3K integrates the action of insulin and leptin on hypothalamic neurons

11 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

IRS2 takes center stage in the development of type 2 diabetes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Insulin receptor substrate proteins and neuroendocrine function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Role of brain insulin receptor in control of body weight and reproduction.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Generalized lacZ expression with the ROSA26 Cre reporter strain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Disruption of IRS-2 causes type 2 diabetes in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Nestin expression in pancreatic exocrine cell lineages.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

High-resolution magnetic resonance imaging tracks changes in organ and tissue mass in obese and aging rats.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069106

Adipose tissue volume measured by magnetic resonance imaging and computerized tomography in rats

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15841180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IRS-2 pathways integrate female reproduction and energy homeostasis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15841180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI24445

1 reference

13 October 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841180%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference