(Q34116730)

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The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

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scholarly article

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Europe PubMed Central

31 July 2017

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane (English)

1 reference

Europe PubMed Central

31 July 2017

phosphorylation

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based on heuristic

inferred from title

object named as

S Betzi

4

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author name string

N Berndt

1

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Europe PubMed Central

31 July 2017

H Yang

2

1 reference

Europe PubMed Central

31 July 2017

B Trinczek

3

1 reference

Europe PubMed Central

31 July 2017

Z Zhang

5

1 reference

Europe PubMed Central

31 July 2017

B Wu

6

1 reference

Europe PubMed Central

31 July 2017

N J Lawrence

7

1 reference

Europe PubMed Central

31 July 2017

M Pellecchia

8

1 reference

Europe PubMed Central

31 July 2017

E Schönbrunn

9

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Europe PubMed Central

31 July 2017

J Q Cheng

10

1 reference

Europe PubMed Central

31 July 2017

S M Sebti

11

1 reference

Europe PubMed Central

31 July 2017

publication date

21 May 2010

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Europe PubMed Central

31 July 2017

Cell Death & Differentiation

1 reference

Europe PubMed Central

31 July 2017

17

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Europe PubMed Central

31 July 2017

11

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Europe PubMed Central

31 July 2017

1795-1804

1 reference

Europe PubMed Central

31 July 2017

https://scigraph.springernature.com/pub.10.1038/cdd.2010.63

0 references

Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT.

1 reference

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The Akt kinases: isoform specificity in metabolism and cancer

1 reference

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Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells

1 reference

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PIKKing on PKB: regulation of PKB activity by phosphorylation

1 reference

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Metastasis and AKT activation

1 reference

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5 July 2018

PHLiPPing the switch on Akt and protein kinase C signaling

1 reference

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PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

1 reference

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

1 reference

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AKT/PKB signaling: navigating downstream

1 reference

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Roles of AKT signal in breast cancer

1 reference

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The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

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1 reference

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The Akt/PKB pathway: molecular target for cancer drug discovery

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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Role for Akt3/protein kinase Bgamma in attainment of normal brain size

1 reference

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5 July 2018

Deregulated Akt3 activity promotes development of malignant melanoma

1 reference

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Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1.

1 reference

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5 July 2018

Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes

1 reference

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5 July 2018

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

1 reference

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5 July 2018

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2952662

5 July 2018

Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2952662

5 July 2018

The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2952662

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Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

1 reference

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CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2952662

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Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2952662

5 July 2018

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2952662

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Downregulation of Akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cells

1 reference

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

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AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

1 reference

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1 reference

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1 reference

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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12 December 2020

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10.1038/CDD.2010.63

1 reference

Europe PubMed Central

31 July 2017

PMC publication ID

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Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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