(Q34121033)

31 July 2017

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title

Antibiotic discovery in the twenty-first century: current trends and future perspectives (English)

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31 July 2017

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Stefano Donadio

1

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31 July 2017

Sonia Maffioli

2

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31 July 2017

Paolo Monciardini

3

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31 July 2017

Margherita Sosio

4

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31 July 2017

Daniela Jabes

5

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31 July 2017

publication date

16 June 2010

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The Journal of Antibiotics

31 July 2017

published in

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31 July 2017

volume

63

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31 July 2017

issue

8

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31 July 2017

page(s)

423-430

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

31 July 2017

cites work

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Future antibiotics scenarios: is the tide starting to turn?

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Microbial natural products: alive and well in 1998.

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Contributions of microorganisms to industrial biology

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New strategies and methods in the discovery of natural product anti-infective agents: the mannopeptimycins

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Antibiotic-resistant bugs in the 21st century--a clinical super-challenge

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Human pharmacokinetics and rationale for once-weekly dosing of dalbavancin, a semi-synthetic glycopeptide

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A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections

21 January 2018

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Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model

21 January 2018

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In vitro activity of API-1252, a novel FabI inhibitor, against clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis

21 January 2018

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The lipopeptide antibiotic Friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol phosphate

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In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases

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NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum beta-lactamases and carbapenemases

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In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa

21 January 2018

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In vitro activity of NXL104 in combination with beta-lactams against Klebsiella pneumoniae isolates producing KPC carbapenemases

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Activity of the siderophore monobactam BAL30072 against multiresistant non-fermenters

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Abyssomicin C-A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway

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Abyssomicins G and H and atrop-abyssomicin C from the marine Verrucosispora strain AB-18-032.

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Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

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Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class.

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The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties

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Specific, efficient, and selective inhibition of prokaryotic translation initiation by a novel peptide antibiotic

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Novel tetrapeptide inhibitors of bacterial protein synthesis produced by a Streptomyces sp.

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Lantibiotics: peptides of diverse structure and function.

21 January 2018

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Determining the structure and mode of action of microbisporicin, a potent lantibiotic active against multiresistant pathogens.

21 January 2018

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Structure revision of the lantibiotic 97518.

21 January 2018

1 reference

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Insights into the mode of action of the two-peptide lantibiotic haloduracin

21 January 2018

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Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13

21 January 2018

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Natural products to drugs: natural product-derived compounds in clinical trials

21 January 2018

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Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.

21 January 2018

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Antibacterial evaluations of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa

21 January 2018

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Isolation, structure, and antibacterial activity of philipimycin, a thiazolyl peptide discovered from Actinoplanes philippinensis MA7347.

21 January 2018

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Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system

21 January 2018

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Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.

21 January 2018

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The growing impact of click chemistry on drug discovery

21 January 2018

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Diazo transfer-click reaction route to new, lipophilic teicoplanin and ristocetin aglycon derivatives with high antibacterial and anti-influenza virus activity: an aggregation and receptor binding study.

21 January 2018

1 reference

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Synthesis of platensimycin

21 January 2018

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Total synthesis and antibacterial properties of carbaplatensimycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.62

Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.62

Synthesis and biological evaluation of platensimycin analogs

21 January 2018

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A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics

21 January 2018

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A robust platform for the synthesis of new tetracycline antibiotics

21 January 2018

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Functional and biochemical analysis of a key series of ramoplanin analogues

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.62

Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2010.62

Mannopeptimycins, a novel class of glycopeptide antibiotics active against gram-positive bacteria

21 January 2018

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Antibiotics GE23077, novel inhibitors of bacterial RNA polymerase. Part 3: Chemical derivatization.

21 January 2018

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Natural products as leads to potential drugs: an old process or the new hope for drug discovery?

21 January 2018

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Prescription for an ailing pharmaceutical industry

21 January 2018

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7 January 2021

Thuggacins, Macrolide Antibiotics Active againstMycobacterium tuberculosis: Isolation from Myxobacteria, Structure Elucidation, Conformation Analysis and Biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.62

7 January 2021

Chapter 1. Approaches to discovering novel antibacterial and antifungal agents

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.62

7 January 2021

Strategies for the isolation and characterization of antibacterial lantibiotics

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.62

7 January 2021

Identification of a novel two-peptide lantibiotic, haloduracin, produced by the alkaliphile Bacillus halodurans C-125

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.62

7 January 2021

Multisite Modification of Neomycin B: Combined Mitsunobu and Click Chemistry Approach

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.62

7 January 2021

Synthesis and preliminary biological characterization of new semisynthetic derivatives of ramoplanin

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.62

7 January 2021

Semisynthetic approaches to laspartomycin analogues

1 reference

https://api.crossref.org/works/10.1038%2FJA.2010.62

7 January 2021

Identifiers

DOI

10.1038/JA.2010.62

1 reference

Dimensions Publication ID

31 July 2017

1024164392

0 references

1 reference