(Q34121060)

31 July 2017

title

Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons (English)

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31 July 2017

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8

Rose-Mary N Boustany

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31 July 2017

Sumeer Dhar

1

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31 July 2017

Rhonda L Bitting

2

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31 July 2017

Svetlana N Rylova

3

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31 July 2017

Paul J Jansen

4

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31 July 2017

Ellen Lockhart

5

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31 July 2017

Dwight D Koeberl

6

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31 July 2017

Andrea Amalfitano

7

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31 July 2017

publication date

1 April 2002

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31 July 2017

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31 July 2017

volume

51

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31 July 2017

issue

4

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31 July 2017

page(s)

448-466

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The neuronal ceroid lipofuscinoses in human EPMR and mnd mutant mice are associated with mutations in CLN8

31 July 2017

cites work

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Biosynthesis and intracellular targeting of the CLN3 protein defective in Batten disease

21 January 2018

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CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide

21 January 2018

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Expression of cln3 in human NT2 neuronal precursor cells and neonatal rat brain

21 January 2018

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Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

21 January 2018

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Action of BTN1, the yeast orthologue of the gene mutated in Batten disease

21 January 2018

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A disrupted homologue of the human CLN3 or juvenile neuronal ceroid lipofuscinosis gene in Saccharomyces cerevisiae: a model to study Batten disease.

21 January 2018

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Cathepsin D targeted by acid sphingomyelinase-derived ceramide

21 January 2018

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A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration

21 January 2018

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Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells

21 January 2018

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Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells

21 January 2018

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Lysosomal ceroid depletion by drugs: therapeutic implications for a hereditary neurodegenerative disease of childhood

21 January 2018

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Channel formation by antiapoptotic protein Bcl-2.

21 January 2018

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VDAC regulation by the Bcl-2 family of proteins

21 January 2018

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Mitochondria and apoptosis: HQ or high-security prison?

21 January 2018

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Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

21 January 2018

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Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

21 January 2018

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An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

21 January 2018

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Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication.

21 January 2018

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Novel approaches in diagnosis and therapy of Creutzfeldt-Jakob disease

21 January 2018

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Association of increased bcl-2 expression with rescue from tumor necrosis factor-alpha-induced cell death in the oligodendrocyte cell line OLN-93.

21 January 2018

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Effect of the triaminopyridine flupirtine on calcium uptake, membrane potential and ATP synthesis in rat heart mitochondria.

21 January 2018

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Mitochondria and cell death. Mechanistic aspects and methodological issues

21 January 2018

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Antioxidant properties of the triaminopyridine, flupirtine

21 January 2018

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NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell

21 January 2018

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A simplified system for generating recombinant adenoviruses

21 January 2018

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Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors

21 January 2018

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Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

21 January 2018

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Specific alterations in levels of mannose 6-phosphorylated glycoproteins in different neuronal ceroid lipofuscinoses

21 January 2018

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Flupirtine increases the levels of glutathione and Bc1-2 in hNT (human Ntera/D1) neurons: mode of action of the drug-mediated anti-apoptotic effect

21 January 2018

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NMDA receptor-mediated K+ efflux and neuronal apoptosis

21 January 2018

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Mutations in a novel CLN6-encoded transmembrane protein cause variant neuronal ceroid lipofuscinosis in man and mouse

21 January 2018

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Detection of eight novel palmitoyl protein thioesterase (PPT) mutations underlying infantile neuronal ceroid lipofuscinosis (INCL;CLN1)

21 January 2018

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Apoptosis as the mechanism of neurodegeneration in Batten's disease.

21 January 2018

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Upregulation of Bcl-2 and elevation of ceramide in Batten disease

21 January 2018

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N-Methyl-d-aspartate and α2-adrenergic mechanisms are involved in the depressent action of flupirtine on spinal reflexes in rats

21 January 2018

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Effect of flupirtine on cell death of human umbilical vein endothelial cells induced by reactive oxygen species

21 January 2018

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Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells

21 January 2018

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Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126)

21 January 2018

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Protection of mitochondrial integrity from oxidative stress by the triaminopyridine derivative flupirtine

21 January 2018

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Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: prevention of amyloid-induced glutathione depletion.

21 January 2018

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Flupirtine protects neurons against excitotoxic or ischemic damage and inhibits the increase in cytosolic Ca2+ concentration

21 January 2018

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Involvement of activated caspase-3-like proteases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANA.10143

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31 July 2017

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