(Q34121488)

31 July 2017

title

Regulation of Skp2 levels by the Pim-1 protein kinase (English)

1 reference

31 July 2017

Bo Cen

1

1 reference

31 July 2017

Sandeep Mahajan

2

1 reference

31 July 2017

Marina Zemskova

3

1 reference

31 July 2017

Zanna Beharry

4

1 reference

31 July 2017

Ying-Wei Lin

5

1 reference

31 July 2017

Scott D Cramer

6

1 reference

31 July 2017

Michael B Lilly

7

1 reference

31 July 2017

Andrew S Kraft

8

1 reference

31 July 2017

language of work or name

English

0 references

publication date

27 July 2010

1 reference

Journal of Biological Chemistry

31 July 2017

published in

1 reference

31 July 2017

volume

285

1 reference

31 July 2017

issue

38

1 reference

31 July 2017

page(s)

29128-29137

1 reference

describes a project that uses

31 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2937943/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization

5 July 2018

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5 July 2018

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Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer

5 July 2018

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Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells

5 July 2018

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Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

5 July 2018

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5 July 2018

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Potential roles for the PIM1 kinase in human cancer - a molecular and therapeutic appraisal

5 July 2018

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Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

5 July 2018

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5 July 2018

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The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells.

5 July 2018

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Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

5 July 2018

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AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex

5 July 2018

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The anaphase promoting complex/cyclosome: a machine designed to destroy

5 July 2018

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Structure and substrate specificity of the Pim-1 kinase

5 July 2018

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Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1.

5 July 2018

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5 July 2018

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The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates

5 July 2018

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Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

5 July 2018

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The serine/threonine kinase Pim-1

5 July 2018

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Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.

5 July 2018

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Culture of mouse prostatic epithelial cells from genetically engineered mice

5 July 2018

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An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant

5 July 2018

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Multi-kinase phosphorylation of the APC/C activator Cdh1 revealed by mass spectrometry.

5 July 2018

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The SCF ubiquitin ligase: insights into a molecular machine

5 July 2018

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The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint

5 July 2018

1 reference

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Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

5 July 2018

1 reference

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Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

5 July 2018

1 reference

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Overexpression of the oncogenic kinase Pim-1 leads to genomic instability.

5 July 2018

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Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Skp2 regulates Myc protein stability and activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Pim-1 associates with protein complexes necessary for mitosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Delineation of prognostic biomarkers in prostate cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Skp2 is oncogenic and overexpressed in human cancers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Role of the F-box protein Skp2 in lymphomagenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Mitotic regulation of the APC activator proteins CDC20 and CDH1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937943

Myc-driven murine prostate cancer shares molecular features with human prostate tumors

5 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.137240

PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.137240

Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.137240

Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.137240

Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.137240

Mechanism of beta 1-integrin-mediated hepatoma cell growth involves p27 and S-phase kinase-associated protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.137240

Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.137240

Hepatocyte growth factor and the kidney: it is not just for the liver

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20663873

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20663873

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.137240

1 reference

31 July 2017

1 reference

31 July 2017

1 reference