(Q34125463)

31 July 2017

Frequent intracellular clonal expansions of somatic mtDNA mutations: significance and mechanisms (English)

1 reference

31 July 2017

Hilary A Coller

1

1 reference

31 July 2017

Natalya D Bodyak

series ordinal

2

1 reference

31 July 2017

Konstantin Khrapko

series ordinal

3

1 reference

31 July 2017

language of work or name

English

0 references

publication date

1 April 2002

1 reference

Annals of the New York Academy of Sciences

31 July 2017

1 reference

31 July 2017

959

1 reference

31 July 2017

434-447

1 reference

The biologic clock: the mitochondria?

31 July 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Complementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell within distinct organelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Human mitochondria and mitochondrial genome function as a single dynamic cellular unit

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Transcomplementation between different types of respiration-deficient mitochondria with different pathogenic mutant mitochondrial DNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Very rare complementation between mitochondria carrying different mitochondrial DNA mutations points to intrinsic genetic autonomy of the organelles in cultured human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Mitochondria in organismal aging and degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Organization of multiple nucleoids and DNA molecules in mitochondria of a human cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Detection of "deleted" mitochondrial genomes in cytochrome-c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Two novel pathogenic mitochondrial DNA mutations affecting organelle number and protein synthesis. Is the tRNA(Leu(UUR)) gene an etiologic hot spot?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

The reductive hotspot hypothesis: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Evidence from human oocytes for a genetic bottleneck in an mtDNA disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Mitochondrial mutational spectra in human cells and tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Modelling the effects of age-related mtDNA mutation accumulation; Complex I deficiency, superoxide and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Mitochondrial DNA mutations and neuromuscular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

A proposed refinement of the mitochondrial free radical theory of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Changes in mitochondrial shape and distribution induced by ethacrynic acid and the transient formation of a mitochondrial reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

Human mitochondria: distinct organelles or dynamic network?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2002.TB02113.X

10.1111/J.1749-6632.2002.TB02113.X

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference