(Q34138263)

31 July 2017

title

Harnessing transposons for cancer gene discovery (English)

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31 July 2017

1

Neal G Copeland

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31 July 2017

2

Nancy A Jenkins

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31 July 2017

language of work or name

English

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publication date

16 September 2010

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31 July 2017

published in

Nature Reviews Cancer

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31 July 2017

volume

10

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31 July 2017

issue

10

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31 July 2017

page(s)

696-706

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Horizontal transmission, vertical inactivation, and stochastic loss of mariner-like transposable elements

31 July 2017

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Transcription start regions in the human genome are favored targets for MLV integration

31 March 2020

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Retroviral insertion sites and cancer: fountain of all knowledge?

31 March 2020

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Resident aliens: the Tc1/mariner superfamily of transposable elements

31 March 2020

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Identification of functional domains and evolution of Tc1-like transposable elements

31 March 2020

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Development of hyperactive sleeping beauty transposon vectors by mutational analysis

31 March 2020

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Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells

31 March 2020

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Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates

31 March 2020

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Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system

31 March 2020

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Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells

31 March 2020

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Mammalian germ-line transgenesis by transposition.

31 March 2020

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Transposition and gene disruption in the male germline of the mouse

31 March 2020

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Regulated transposition of a fish transposon in the mouse germ line

31 March 2020

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Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice.

31 March 2020

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The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition

31 March 2020

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Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1.

31 March 2020

1 reference

Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells.

31 March 2020

1 reference

Nonhomologous-End-Joining Factors Regulate DNA Repair Fidelity during Sleeping Beauty Element Transposition in Mammalian Cells

31 March 2020

1 reference

Sleeping beauty transposase has an affinity for heterochromatin conformation

31 March 2020

1 reference

Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation

31 March 2020

1 reference

Postintegrative gene silencing within the Sleeping Beauty transposition system

31 March 2020

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DNA methylation of Sleeping Beauty with transposition into the mouse genome.

31 March 2020

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Sleeping Beauty transposition in the mouse genome is associated with changes in DNA methylation at the site of insertion.

31 March 2020

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Cytosine methylation and mammalian development

31 March 2020

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Cytosine methylation and the ecology of intragenomic parasites

31 March 2020

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Target-site preferences of Sleeping Beauty transposons.

31 March 2020

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Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements.

31 March 2020

1 reference

High-resolution genome-wide mapping of transposon integration in mammals

31 March 2020

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Characterization of Sleeping Beauty transposition and its application to genetic screening in mice

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

31 March 2020

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Gene transfer into genomes of human cells by the sleeping beauty transposon system.

31 March 2020

1 reference

Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon

31 March 2020

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Chromosomal mobilization and reintegration of Sleeping Beauty and PiggyBac transposons.

31 March 2020

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Generalized lacZ expression with the ROSA26 Cre reporter strain

31 March 2020

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Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells

31 March 2020

1 reference

Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers

31 March 2020

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TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

31 March 2020

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Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

31 March 2020

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Mutations of the BRAF gene in human cancer

31 March 2020

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Alterations of cancer-related genes in soft tissue sarcomas: hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma.

31 March 2020

1 reference

Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality

31 March 2020

1 reference

Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen

31 March 2020

1 reference

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus

31 March 2020

1 reference

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice

31 March 2020

1 reference

Efficient selection for high-expression transfectants with a novel eukaryotic vector

31 March 2020

1 reference

'Green mice' as a source of ubiquitous green cells.

31 March 2020

1 reference

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

31 March 2020

1 reference

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

31 March 2020

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Colorectal cancer and genetic alterations in the Wnt pathway

31 March 2020

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Inactivation of hCDC4 can cause chromosomal instability

31 March 2020

1 reference

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

31 March 2020

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Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

31 March 2020

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Genetics of hepatocellular carcinoma

31 March 2020

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Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm

31 March 2020

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Pivotal role of mTOR signaling in hepatocellular carcinoma

31 March 2020

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Genomics and signaling pathways in hepatocellular carcinoma.

31 March 2020

1 reference

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

31 March 2020

1 reference

Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis

31 March 2020

1 reference

MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course.

31 March 2020

1 reference

Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation

31 March 2020

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Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis

31 March 2020

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Hepatitis B virus. The major etiology of hepatocellular carcinoma

31 March 2020

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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide

31 March 2020

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Hepatitis B e antigen and the risk of hepatocellular carcinoma

31 March 2020

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In vitro transposition of bacteriophage Mu: A biochemical approach to a novel replication reaction

31 March 2020

1 reference

Tagged mutagenesis by efficient Minos-based germ line transposition

31 March 2020

1 reference

Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice

31 March 2020

1 reference

Efficient transposition of Tol2 in the mouse germline

31 March 2020

1 reference

Chromosomal transposition of PiggyBac in mouse embryonic stem cells

31 March 2020

1 reference

Assay for movement of Lepidopteran transposon IFP2 in insect cells using a baculovirus genome as a target DNA.

31 March 2020

1 reference

Precise excision of TTAA-specific lepidopteran transposons piggyBac (IFP2) and tagalong (TFP3) from the baculovirus genome in cell lines from two species of Lepidoptera

31 March 2020

1 reference

Generation of an inducible and optimized piggyBac transposon system.

31 March 2020

1 reference

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

31 March 2020

1 reference

Comparative analysis of transposable element vector systems in human cells

31 March 2020

1 reference

Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains

31 March 2020

1 reference

piggyBac can bypass DNA synthesis during cut and paste transposition

31 March 2020

1 reference

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

31 March 2020

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Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

31 March 2020

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Detecting statistically significant common insertion sites in retroviral insertional mutagenesis screens

31 March 2020

1 reference

Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks

31 March 2020

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Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation

31 March 2020

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Splinkerettes--improved vectorettes for greater efficiency in PCR walking.

31 March 2020

1 reference

Pooled library tissue tags for EST-based gene discovery

31 March 2020

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Preferential transposition of Drosophila P elements to nearby chromosomal sites

31 March 2020

1 reference

12 December 2020

A minor tyrosine phosphorylation site located within the CAIN domain plays a critical role in regulating tissue-specific transformation by erbB kinase

1 reference

12 December 2020

In vitro c-met inhibition by antisense RNA and plasmid-based RNAi down-modulates migration and invasion of hepatocellular carcinoma cells.

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12 December 2020

Mutation rate of MAP2K4/MKK4 in breast carcinoma

1 reference

12 December 2020

Transposon Mutagenesis of the Mouse Germline

1 reference

12 December 2020

Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes

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12 December 2020

Repetitive elements and their genetic applications in zebrafish

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12 December 2020

Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC2916

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Dimensions Publication ID

31 July 2017

1051147671

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