(Q34139347)

31 July 2017

A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi (English)

1 reference

31 July 2017

0 references

aminopropylcadaverine

1 reference

ChEBI release 2020-05-28

1 reference

Sandra L Oza

1

0 references

Alan Fairlamb

object named as

Alan H Fairlamb

series ordinal

5

0 references

Emmanuel Tetaud

series ordinal

2

object named as

Emmanuel Tetaud

1 reference

31 July 2017

3

Mark R Ariyanayagam

1 reference

31 July 2017

Stephanie S Warnon

4

1 reference

PubMed ID

12121990

31 July 2017

language of work or name

English

0 references

publication date

16 July 2002

1 reference

Journal of Biological Chemistry

31 July 2017

1 reference

31 July 2017

277

1 reference

31 July 2017

35853-35861

1 reference

31 July 2017

39

1 reference

Polyamines as targets for therapeutic intervention

31 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Roles of the glutathione- and thioredoxin-dependent reduction systems in the Escherichia coli and saccharomyces cerevisiae responses to oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Metabolism and functions of trypanothione in the Kinetoplastida

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Glutathione and trypanothione in parasitic hydroperoxide metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

The biosynthesis of trypanothione and N1-glutathionylspermidine in Crithidia fasciculata.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Regulation of a high-affinity diamine transport system in Trypanosoma cruzi epimastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

DNA sequencing with chain-terminating inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Levels of polyamines, glutathione and glutathione-spermidine conjugates during growth of the insect trypanosomatid Crithidia fasciculata.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Diamine auxotrophy may be a universal feature of Trypanosoma cruzi epimastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Peroxynitrite affects Ca2+ transport in Trypanosoma cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Ovothiol and trypanothione as antioxidants in trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Evidence for a trypanothione-dependent peroxidase system in Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Glutathione-dependent activities of Trypanosoma cruzi p52 makes it a new member of the thiol:disulphide oxidoreductase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Intracellular growth and metacyclogenesis defects in Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Convenient isolation and kinetic mechanism of glutathionylspermidine synthetase from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3' end

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Solid-phase extraction and determination of dansyl derivatives of unconjugated and acetylated polyamines by reversed-phase liquid chromatography: improved separation systems for polyamines in cerebrospinal fluid, urine and tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Dissection of glutathionylspermidine synthetase/amidase from Escherichia coli into autonomously folding and functional synthetase and amidase domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

Glutathione as an endogenous sulphur source in the yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204403200

21 January 2018

Identifiers

DOI

10.1074/JBC.M204403200

1 reference

31 July 2017

1 reference

PubMed ID

12121990