(Q34139503)

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Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex

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Europe PubMed Central

PubMed publication ID

31 July 2017

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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David Robert Mole

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David R Mole

1

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Peter J. Ratcliffe

object named as

Peter J Ratcliffe

3

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Christopher J A Pugh

2

object named as

Christopher W Pugh

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Europe PubMed Central

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31 July 2017

Patrick H. Maxwell

4

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Patrick H Maxwell

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Europe PubMed Central

PubMed publication ID

31 July 2017

publication date

1 January 2002

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Europe PubMed Central

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31 July 2017

Advances in Enzyme Regulation

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Europe PubMed Central

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31 July 2017

42

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Europe PubMed Central

PubMed publication ID

31 July 2017

333-347

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1 reference

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7 January 2021

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

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based on heuristic

inferred from DOI database lookup

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

1 reference

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

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based on heuristic

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Cytochromes and oxygen radicals as putative members of the oxygen sensing pathway

1 reference

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based on heuristic

inferred from DOI database lookup

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

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Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1 reference

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Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein

1 reference

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

1 reference

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The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The VHL tumour-suppressor gene paradigm

1 reference

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based on heuristic

inferred from DOI database lookup

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1 reference

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based on heuristic

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Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

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based on heuristic

inferred from DOI database lookup

PR39, a peptide regulator of angiogenesis

1 reference

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Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900037-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900037-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the HIF pathway in cancer

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900037-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900037-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900037-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900037-1

7 January 2021

based on heuristic

inferred from DOI database lookup

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900037-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900037-1

7 January 2021

based on heuristic

inferred from DOI database lookup

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

HIF-1 and mechanisms of hypoxia sensing

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2571%2801%2900037-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

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7 January 2021

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inferred from DOI database lookup

Identifiers

10.1016/S0065-2571(01)00037-1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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