(Q34150461)

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Modular enzymes

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scholarly article

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Europe PubMed Central

PubMed publication ID

31 July 2017

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Europe PubMed Central

Modular enzymes (English)

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Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

Khosla C

1

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Europe PubMed Central

PubMed publication ID

31 July 2017

Harbury PB

2

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Europe PubMed Central

PubMed publication ID

31 July 2017

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publication date

1 January 2001

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Europe PubMed Central

PubMed publication ID

31 July 2017

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Europe PubMed Central

PubMed publication ID

31 July 2017

409

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Europe PubMed Central

PubMed publication ID

31 July 2017

6817

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Europe PubMed Central

PubMed publication ID

31 July 2017

247-252

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Europe PubMed Central

PubMed publication ID

31 July 2017

General nature of the genetic code for proteins

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Modular binding domains in signal transduction proteins

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From Src Homology domains to other signaling modules: proposal of the 'protein recognition code'.

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Modular structure of transcription factors: implications for gene regulation

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Imposing specificity by localization: mechanism and evolvability

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Location of domains in globular proteins

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Protein superfamilies and domain superfolds

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Gene families: the taxonomy of protein paralogs and chimeras

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Protein evolution viewed through Escherichia coli protein sequences: introducing the notion of a structural segment of homology, the module.

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Protein alchemy: changing beta-sheet into alpha-helix

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Functional domains in Fok I restriction endonuclease.

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Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

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Splase: a new class IIS zinc-finger restriction endonuclease with specificity for Sp1 binding sites.

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Novel site-specific DNA endonucleases

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Homologous xylanases from Clostridium thermocellum: evidence for bi-functional activity, synergism between xylanase catalytic modules and the presence of xylan-binding domains in enzyme complexes.

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Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity

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Detecting protein function and protein-protein interactions from genome sequences

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On the attribution and additivity of binding energies

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Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme

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Engineering Src family protein kinases with unnatural nucleotide specificity

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Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity

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Rapid evolution of a protein in vitro by DNA shuffling

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Bacterial biocatalysts: molecular biology, three-dimensional structures, and biotechnological applications of lipases

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Enzymes and protecting group chemistry

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A structure-activity study with aryl acylamidases

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Penicillin acylase has a single-amino-acid catalytic centre

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Ligand-induced conformational change in penicillin acylase

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Structural basis of the chiral selectivity of Pseudomonas cepacia lipase

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Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine.

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The 1.9 Å crystal structure ofEscherichia coliMurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis

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The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation

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Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety

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A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D

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Conserved domains of glycosyltransferases

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Harnessing the biosynthetic code: combinations, permutations, and mutations

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Tolerance and specificity of polyketide synthases

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Design and application of multimodular peptide synthetases

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Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis

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Analysis of the Molecular Recognition Features of Individual Modules Derived from the Erythromycin Polyketide Synthase

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Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

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A novel, definitive test for substrate channeling illustrated with the aspartate aminotransferase/malate dehydrogenase system

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Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site

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Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product

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Swinging arms in multifunctional enzymes and the specificity of post-translational modification

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Preferential heterodimer formation by isolated leucine zippers from fos and jun

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

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Modular organization of genes required for complex polyketide biosynthesis

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Identifiers

10.1038/35051723

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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